Synthesis of novel 4,5-diphenylthiazole derivatives as potential acyl- Coa: Cholesterol O-acyltransferase inhibitors

Pharmazie

Volumn 54, Issue 1, 1999, Pages 19-23

  Romeo, G ^b   Salerno, L ^b   Milla, P ^b   Siracusa, M ^b   Cattel, L ^b   Russo, Filippo ^a  

^a UNIVERSITY OF CATANIA   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

4,5 DIPHENYLTHIAZOLE DERIVATIVE; CARBON 14; CHOLESTEROL; CHOLESTEROL ACYLTRANSFERASE; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; CHOLESTEROL OLEATE; IMIDAZOLE DERIVATIVE; ISOCYANATE; ISOTHIOCYANIC ACID; N (4,5 DIPHENYLTHIAZOL 2 YL) N' [2,6 BIS(2 METHYLETHYL)PHENYL]UREA; N (4,5 DIPHENYLTHIAZOL 2 YL) N',N BUTYLUREA; OLEOYL COENZYME A; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; LIVER MICROSOME; MALE; NONHUMAN; RAT; REACTION ANALYSIS;

ANIMALS; ENZYME INHIBITORS; MALE; MICROSOMES, LIVER; PHENYLUREA COMPOUNDS; RATS; RATS, WISTAR; STEROL O-ACYLTRANSFERASE; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; UREA;

EID: 0032897316     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Sliskovic, D. R.; Trivedi, B. K.: Curr. Med. Chem. 1, 205 (1994)
2. Matsuda, K.: Med. Res. Rev. 14, 271 (1994)
3. Roark, W. H.; Roth, B. D.; Trivedi, B. K.: Eur. Pat. Appl. EP 297,610 (Cl. C07C127/19), 4 Jan 1989, US Appl. 69,066, 2 Jul 1987
4. Fukumaru, T.; Hamma, N.; Nakatami, H.; Fukushima, H.; Toki, K.: US 3,784,577 (Cl. 260-404; A 61k), 8 Jan 1974, Appl. 671,228,28 Sep 1967
5. Harris, N. V.; Smith, C.; Ashton, M. J.; Bridge, A. W.; Bush, R. C.; Coffee, E. C. J.; Dron, D. I.; Harper, M. F.; Lythgoe, D. J.; Newton, C. G.; Riddel, D.: J. Med. Chem. 35, 4384 (1992)
6. Yoshikawa, Y.; Saito, H.; Oochi, Y.; Ochi, Y.: Jpn. Kokai Tokkyo Koho JP 04,173,782 [92,173,782] (Cl. C07D277/52), 22 Jun 1992, Appl. 90/302,853,8 Nov 1990
7. Bogert, M. T.; Chertcoff, M.: J. Am. Chem. Soc. 46, 2864 (1924)
8. Nishimura, T.; Katajima, K.: J. Org. Chem. 44, 818 (1979)
9. Srivastava, P. K.; Upadhyaya, S.; Sharma, R. D.: J. Chem. Eng. Data 21, 508 (1976)
10. Liebig, H.; Pfetzing, H.; Grafe, A.: Arzneim.-Forsch. 24, 887 (1974)
11. Peterson, G. L.: Analytical Biochemistry 83, 346 (1977)
12. Lichtenstein, A. M.; Brecher, P.: J. Biol. Chem. 255, 9098 (1980)
13. Harnett, K. M.; Walsh, C. T.; Zhang, L.: J. Pharmacol. Exp. Ther. 251, 502 (1989)