The degradation profile of extrachromosomal circular DNA during cisplatin-induced apoptosis is consistent with preferential cleavage at matrix attachment regions

Chromosoma

Volumn 108, Issue 2, 1999, Pages 121-131

  Schoenlein, P V ^a   Barrett, J T ^a   Welter, D ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CIRCULAR DNA; CISPLATIN; DNA FRAGMENT; EXTRACHROMOSOMAL DNA;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER GROWTH; CELL DEATH; CELL NUCLEUS MEMBRANE; CELL STRUCTURE; CHROMATIN; CONTROLLED STUDY; DNA DEGRADATION; DNA STRUCTURE; DOSE RESPONSE; DOUBLE MINUTE CHROMOSOME; DRUG RESISTANCE; EPISOME; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GIEMSA STAIN; HUMAN; HUMAN CELL; MICROSCOPY; MOLECULAR WEIGHT; ONCOGENE; SCANNING ELECTRON MICROSCOPY; SQUAMOUS CELL CARCINOMA;

APOPTOSIS; BINDING SITES; CISPLATIN; DNA, CIRCULAR; HUMANS; HYDROLYSIS; IN SITU HYBRIDIZATION, FLUORESCENCE; MICROSCOPY, ELECTRON, SCANNING; MOLECULAR WEIGHT; NUCLEAR MATRIX; P-GLYCOPROTEIN; TUMOR CELLS, CULTURED;

EID: 0032897305     PISSN: 00095915     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004120050359     Document Type: Article

References (72)

1. Abken H (1995) Extrachromosomal DNA elements in human tumor cells. Cancer J 8:94-102
2. Arenas MJ, Morris RG, Wyllie H (1990) Apoptosis: the role of endonuclease. Am J Pathol 136:593-608
3. Barsoum J, Levinger L, Varshavsky A (1982) On the chromatin structure of the amplified transcriptionally active gene for dihydrofolate reductase in mouse cells. J Biol Chem 257:5274-5282
4. Benner SE, Wahl GM, Von Hoff DD (1991) Double minute chromosomes and homogeneously staining regions in tumors taken directly from patients versus in human tumor cell lines. Anticancer Drugs 2:11-25
5. Bidwell JP, Fey EG, van Wijnen AJ, Penman S, Stein JL, Lian JB, Stein GS (1994) Nuclear matrix proteins distinguish normal diploid osteoblasts from osteosarcoma cells. Cancer Res 54:28-32
6. Biedler JL, Spengler BA (1976) Metaphase chromosome anomaly: association with drug resistance and cell-specific products. Science 191:185-187
7. Biedler JL, Melera PW, Spengler BA (1980) Specifically altered metaphase chromosomes in antifolate-resistant Chinese hamster cells that overproduce dihydrofolate reductase. Cancer Genet Cytogenet 2:47-60
8. Brown DG, Sun X-M, Cohen GM (1993) Dexamethasone-induced apoptosis involves cleavage of DNA into large fragments prior to internucleosomal fragmentation. J Biol Chem 268:3037-3039
9. Carroll SM, Gaudray P, DeRose ML, Emery JF, Meinkoth JL, Nakkim E, Subler M, Von Hoff DD, Wahl GM (1987) Characterization of an episome produced in hamster cells that amplify a transfected CAD gene at high frequency: functional evidence for a mammalian replication origin. Mol Cell Biol 7:1740-1750
10. Christen RD, Shalinsky DR, Howell SB (1992) Enhancement of the loss of multiple drug resistance by hydroxyurea. Semin Oncol 19:94-100
11. Cohen G M, Sun X-M, Snowden R T, Dinsdale D, Skilleter DN (1992) Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation. Biochem J 286:331-334
12. Cohen GM, Sun X-M, Fearnhead H, MacFarlane M, Brown DG, Snowden RT, Dinsdale D (1994) Formation of large molecular weight fragments of DNA is a key committed step of apoptosis in thymocytes. J Immunol 143:507-516
13. Cessons N, Nielsen TO, Dini C, Tomilin N, Young DB, Riabowol KT, Rattner JB, Johnston RN, Zannis-Hadjopoulos M, Price GB (1997) Circular YAC vectors containing a small mammalian origin sequence can associate with the nuclear matrix. J Cell Biochem 67:439-450
14. Dijkwel PA, Hamlin JL (1988) Matrix attachment regions are positioned near replication initiation sites, genes, and an interamplicon junction in the amplified dihydrofolate reductase domain of Chinese Hamster Ovary cells. Mol Cell Biol 8: 5398-5409
15. Dive C, Wyllie AH (1993) Apoptosis and cancer chemotherapy In: Hickman JA, Tritton TR (eds) Frontiers in pharmacology. Blackwell Scientific Press, Oxford, UK pp 21-56
16. Earnshaw WC (1995) Nuclear changes in apoptosis. Curr Opin Cell Biol 7:337-343
17. Eastman A (1990) Activation of programmed cell death by anticancer agents: cisplatin as a model system. Cancer Cells 2:275-280
18. Evans DL, Dive C (1993) Effects of cisplatin on the induction of apoptosis in proliferating hepatoma cells and nonproliferating immature thymocytes. Cancer Res 53:2133-2139
19. Filipski J, Leblanc J, Youdale T, Sikorska M, Walder PR (1990) Periodicity of DNA folding in higher order chromatin structures. EMBO J 9:1319-1327
20. Fojo AT, Whang-Peng J, Gottesman MM, Pastan I (1985) Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells. Proc Natl Acad Sci USA 82:7661-7665
21. Gasser SM, Laemmli U K (1986) Cohabitation of scaffold binding regions with upstream enhancer elements of three developmentally-regulated genes of three developmentally-regulated genes of D melanogaster. Cell 46:521-530
22. Getzenberg RH, Peinta KJ, Ward WS, Coffey DS (1991) Nuclear structure and the three-dimensional organization of DNA. J Cell Biochem 47:289-299
23. Gottesman MM, Hrycyna CA, Schoenlein PV, Germann UA, Pastan I (1995) Genetic analysis of the multidrug transporter. Annu Rev Genet 29:607-49
24. Gromova II, Nielsen OF, Razin SV (1995) Long-range fragmentation of the eukaryotic genome by exogenous and endogenous nucleases proceeds in a specific fashion via preferential DNA cleavage at matrix attachment sites. J Biol Chem 270:18685-18690
25. Hamkalo BA, Farnham PJ, Johnston R, Schimke RT (1985) Ultrastructural features of minute chromosomes in a methotrexate-resistant mouse 3T3 cell line. Proc Natl Acad Sci USA 82:1126-1130
26. Huang P, Ballal K, Plunkett W (1997) Biochemical characterization of the protein activity responsible for high molecular weight DNA fragmentation during drug-induced apoptosis. Cancer Res 57:3407-3414
27. Ishida Y, Agata Y, Shibahara K, Honjo T (1992) Induced expression of PD-1 a novel member of the immunoglobulin gene superfamily upon programmed cell death. EMBO J 11:3887-3895
28. Kerr JFR, Harmon BV (1991) Definition and incidence of apoptosis: an historical perspective. In: Tomie LD, Cope FO (eds) Apoptosis: the molecular basis of cell death. Curr Commun Cell Mol Biol 3:5-29
29. Lagarkova MA, Iarovaia OV, Razin SV (1995) Large-scale fragmentation of mammalian DNA in the course of apoptosis proceeds via excision of chromosomal DNA loops and their oligomers. J Biol Chem 270:20239-20241
30. Lincke CR, Smit JJM, van der Velde-Koerts T, Borst P (1991) Structure of the human MDR3 gene and physical mapping of the human MDR3 gene and physical mapping of the human MDR locus. J Biol Chem 266:5303-5310
31. Livingstone LR, White A, Sprouse J, Livanos E, Jacks T, Tlsty TD (1992) Altered cell cycle arrest and gene amplification potential accompany loss of wild type p53. Cell 70:923-935
32. Mauer BJ, Lai E, Hamkalo BA, Hood L, Attardi G (1987) Novel submicroscopic extrachromosomal elements containing amplified genes in human cells. Nature 327:434-437
33. McGill JR, Beitzel BF, Nielsen JL, Walsh JT, Drabek SM, Meador RJ, Von Hoff DD (1993) Double minutes are frequently found in ovarian carcinomas. Cancer Genet Cytogenet 71:125-131
34. Mirkovitch J, Mireault M-E, Laemmli U K (1984) Organization of the higher order chromatin loop: specific DNA attachment sites on the nuclear scaffold. Cell 39:223-232
35. Mishell BB, Shiigi SM, Henry C, Chan EL, North J, Gallily R, Slomich M, Miller K, Marbrook J, Parks D, Good AH (1980) Preparation of mouse cell suspensions In: Mishell BB, Shiigi SM (eds) Selected methods in cellular immunology. WH Freeman, New York, pp 21-22
36. Murgia M, Pizzo P, Sandona D, Zanovello P, Rizzuto R, DiVirgilio F (1992) Mitochondrial DNA is not fragmented during apoptosis. J of Biol Chem 267:10939-10941
37. Nelson WG, Pienta KJ, Barrack ER, Coffey DS (1986) Annu Rev Biophys Biophys Chem 15:457-475
38. Nielsen JL, Walsh JT, Degen DR, Drabek SM, McGill JR, Von Hoff DD (1993) Evidence of gene amplification in the form of double minute chromosomes is frequently observed in lung cancer. Cancer Genet Cytogenet 65:120-124
39. Oberhammer F, Fritsch G, Schmied M, Pavelka M, Printz D, Purchio T, Lassmann H, Schulte-Hermann R (1993a) Condensation of the chromatin at the membrane of an apoptotic nucleus is not associated with activation of an endonuclease. J Cell Sci 104:317-326
40. Oberhammer F, Wilson JW, Dive C, Morris ID, Wakeling JA, Walker PR, Sikorska M, Hickman JA (1993b) Apoptotic cell death in epithelial cells: cleavage of DNA to 300 and/or 50 kilobase fragments prior to or in the absence of internucleosomal fragmentation. EMBO J 12:3679-3684
41. Ormerod MG, O'Neill CF, Robertson D, Harrap KR (1994) Cis-platin induces apoptosis in a human ovarian carcinoma cell line without concomitant internucleosomal degradation of DNA. Exp Cell Res 211:231-237
42. Partin AW, Getzenberg RH, CarMichael MJ, Vindivich D, Yoo J, Epstein JI, Coffey DS (1993) Nuclear matrix protein patterns in human benign prostatic hyperplasia and prostate cancer. Cancer Res 53:744-746
43. Pauletti G, Lai E, Attardi G (1990) Early appearance and long-term persistence of the submicroscopic extrachromosomal elements (amplisomes) containing the amplified DHFR genes in human cell lines. Proc Natl Acad Sci USA 87:2955-2959
44. Phi-Van L, Stratling WH (1990) Association of DNA with nuclear matrix. Prog Mol Subcell Biol 11:1-11
45. Rattner JB, Lin CC (1984) Ultrastructural organization of double minute chromosomes and HSR regions in human colon carcinoma cells. Cytogenet Cell Genet 38:176-181
46. Razin SV, Gromova I, Iarovaia OV (1995) Specificity and functional significance of DNA interaction with the nuclear matrix: new approaches to clarify the old questions. Int Rev Cytol 162B: 405-448
47. Roy C, Brown DL, Little JE. Valentine BK, Walker PR, Sikorska M, Leblanc J, Chaly N ( 1992) The topoisomerase II inhibitor teniposide (VM-26) induces apoptosis in unstimulated mature lymphocytes. Exp Cell Res 200:416-424
48. Ruiz JC, Choi K, Von Hoff DD, Roninson IB, Wahl GM (1989) Autonomously replicating episomes contain mdr1 genes in a multi-drug-resistant human cell line. Mol Cell Biol 9:109-115
49. Saitoh N, Goldberg I, Earnshaw C (1995) The SMC proteins and the coming of age of the chromosome scaffold hypothesis. BioEssays 17:759-766
50. Sanchez AM, Barrett JT, Schoenlein PV (1998) Fractionated ionizing radiation accelerates loss of extrachromosomally amplified MDR1 genes harbored by extrachromosomal DNA in tumor cells. Cancer Res 58:3845-3854
51. Schimke RT (1988) Gene amplification in cultured cells. J Biol Chem 263:5989-5992
52. Schoenlein PV, Shen D-W, Barrett JT, Pastan I, Gottesman MM (1992) Double minute chromosomes carrying the human MDR1 and MDR2 genes are generated from the dimerization of submicroscopic circular DNAs in cholchicine-selected KB carcinoma cells. Mol Biol Cell 3:507-522
53. Schoenlein PV, VanDevanter DR, Gottesman MM (1993) Extra-chromosomal elements in mammalian cells. In: Adolph EW (ed) Gene and chromosome analysis, part B. Academic Press, San Diego, Calif, pp 78-104
54. Sestili P, Flaminio C, Cantoni O (1996) Direct excision of 50 kb pair DNA fragments from megabase-sized fragments produced during apoplotic cleavage of genomic DNA. FEBS Lett 396: 337-342
55. Shen D-W, Cardarelli C, Hwang J, Cornwell M, Richert N, Ishii S, Pastan I, Gottesman MM (1986) Multiple drug resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin or vinblastine show changes in expression of specific protein. J Biol Chem 261:7762-7770
56. Shimizu N, Kanda T, Wahl G M (1996) Selective capture of acentric fragments by micronuclei provides a rapid method for purifying extrachromosomally amplified DNA. Nat Genet 12:65-71
57. Snapka RM, Varshavsky A (1983) Loss of unstably amplified DH-FR genes from mouse cells is greatly accelerated by hydroxyurea. Proc Natl Acad Sci USA 80:7533-7537
58. Stark GR, Wahl GM (1984) Gene amplification. Annu Rev Biochem 53:447-491
59. Thiebaut F, Hanauske A-R, Von Hoff DD (1993) Evidence for binding of extrachromosomal DNA sequences to nuclear matrix proteins in multidrug-resistant KB-V1 cells. FEBS Lett 319:133-137
60. Tlsty TD, Margolin BH, Lum K (1989) Differences in the rates of gene amplification in nontumorigenic and tumorigenic cell lines as measured by Luria-Delbruck fluctuation analysis. Proc Natl Acad Sci USA 86:9441-9445
61. Tomei LD, Shapiro JP, Cope FO (1993) Apoptosis in C3H/10T1/2 mouse embryonic cells: evidence for internucleosomal DNA modification in the absence of double-strand cleavage. Proc Natl Acad Sci USA 90:853-857
62. Ucker DS, Obermiller PS, Eckhart W, Apgar JR, Berger NA. Meyers J (1992) Genome digestion is a dispensable consequence of physiological cell death mediated by cytotoxic T lymphocytes. Mol Cell Biol 12:3060-3069
63. Vandevanter DR, Piaskowski BD, Casper JT, Douglass EE, Von Hoff DD (1990) Ability of circular extrachromosomal DNA molecules to carry amplifed MYCN proto-oncogenes in human neuroblastomas in vivo. J Natl Cancer Inst 82:815-1821
64. Von Hoff DD, Needham-VanDevanter DR, Yucel J Windle BE, Wahl GM (1988) Amplified human c-myc oncogenes localized to replicating submicroscopic circular DNA molecules. Proc Natl Acad Sci USA 85:4804-4808
65. Von Hoff DD, Waddelow T, Forseth B, Davidson K, Scott J, Wahl GM (1991) Hydroxyurea accelerates loss of extrachromosomally amplified genes from tumor cells. Cancer Res 51:6273-6279
66. Von Hoff DD, McGill J, Davidson K, Forseth B, Ebrahim EAA, Burris H (1992) Preclinical leads for innovative uses of etoposide. Semin Oncol 19:10-13
67. Wahl GM (1989) The importance of circular DNA in mammalian gene amplification. Cancer Res 49:1333-1340
68. Walker PR, Smith C, Youdale T, Leblanc J, Whitefield JF, Sikorska M (1991) Topoisomerase II-reactive drugs induce apoptosis in thymocytes. Cancer Res 51:1078-1085
69. Walker PR, Kokileva L, LeBlanc J, Sikorska M (1993) Detection of the initial stages of DNA fragmentation in apoptosis. BioTechniques 15:1032-1040
70. Walker PR, Weaver VM, Lach B, LeBlanc J, Sikorska M (1994) Endonuclease activities associated with high molecular weight and internucleosomal DNA fragmentation in apoptosis. Exp Cell Res 213:100-106
71. Wyllie AH, Kerr JFR, Currie AR (1980) Cell death: the significance of apoptosis Int Rev Cytol 68:251-306
72. Yin Y, Tainsky MA, Bischoff FZ. Strong LC, Wahl GM (1992) Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell 70:937-948