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2. Then, water was evaporated and the chlorhydrate salt of the synthetic betaine was obtained by stirring the dry residue for 2 h in 5 ml of 2 M aqueous HC1. Finally, the synthetic betaine hydrochloride was purified further by triturating the white solid in dimethylketone. Seven GB analogues [N°: name (yield%)] were synthesised in this study: 61: carboxymethyldimethylethyl ammonium chloride (100%), 62: carboxymethyldiethylmethyl ammonium chloride (95%), 63: carboxymethyltriethyl ammonium chloride (65%), 64: carboxymethyldimethylisopropyl ammonium chloride (95%), 65: carboxymethylbutyldimethyl ammonium chloride (80%), 66: carboxymethylmethylpyrrolidinyl ammonium chloride (75%) and 67: carboxymethylmethylmorpholinyl ammonium chloride (65%).
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In contrast to the situation observed in procedures using bromacetic derivatives no reaction of pyridine with the polymer 4 was observed in our protocol
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