Oxandrolone, used for treatment of wasting disease in HIV-1-infected patients, does not diminish the antiviral activity of deoxynucleoside analogues in lymphocyte and macrophage cell cultures

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology

Volumn 20, Issue 3, 1999, Pages 215-219

  Segal, David M ^a   Perez, Mariela ^a   Shapshak, Paul ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

AIDS; DdC; DdI; HIV 1 replication; IC50; Oxandrolone; P24 antigen; Reverse transcriptase; Wasting; Weight gain; ZDV

Indexed keywords

ANTIGEN P24; DIDANOSINE; OXANDROLONE; RNA DIRECTED DNA POLYMERASE; ZALCITABINE; ZIDOVUDINE;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MACROPHAGE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; WASTING SYNDROME; WEIGHT GAIN;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0032896388     PISSN: 10779450     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042560-199903010-00001     Document Type: Article

References (20)

1. Stoneburner RL, Sato P, Burton A, Mertens T. The global HIV pandemic. Acta Paediatr 1994;400(Suppl):1-4.
2. Palca J. The sobering geography of AIDS. Science 1995;252: 372-3.
3. Berger JR, Pall L, Hall CD, Simpson DM, Berry PS, Dudley R. Oxandrolone in AIDS-wasting myopathy. AIDS 1996;10:1657-62.
4. Meng T-C, Fischl MA, Boota AM, et al. Combination therapy with zidovudine and dideoxycytidine in patients with advanced human immunodeficiency virus infection: a phase I/II study. Ann Intern Med 1992;116:13-20.
5. Parks WP, Parks ES, Fischl MA, et al. HIV-1 inhibition by azidothymidine in a concurrently randomized placebo-controlled trial. J Acquir Immune Defic Syndr 1988;1:125-30.
6. Shapshak P, Sun NCJ, Resnick L, et al. HIV-1 propagates in human neuroblastoma cells. J Acquir Immune Defic Syndr 1991;4: 228-37.
7. Shapshak P, Yoshioka M, Sun NCJ, et al. HIV-1 in post-mortem brain tissue from patients with AIDS: a comparison of different detection techniques. AIDS 1992;6:915-23.
8. St. Clair MH, Martin JL, Tudor-Williams G, et al. Resistance to ddl and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase. Science 1991;253:1557-9.
9. Larder BA, Darby G, Richman DD. HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy. Science 1989;243:1731-4.
10. Japour AJ, Mayers DL, Johnson VA, et al. Standardized peripheral blood mononuclear cell culture assay for determination of drug susceptibilities of clinical human immunodeficiency type 1 isolates. Antimicrob Agents Chemother 1993;37:1095-1101.
11. Karim A, Ranney RE, Zagarella J, Maibach HI. Oxandrolone disposition and metabolism in man. Clin Pharmacol Ther 1973;14: 862-9.
12. Wainberg MA, Gu Z, Gao Q, et al. Clinical correlates and molecular basis of HIV drug resistance. J Acquir Immune Defic Syndr 1993;6(Suppl 1):S36-S46.
13. Richman DD, Kornbluth RS, Carson DA. Failure of dideoxynucleosides to inhibit human immunodeficiency virus replication in cultured human macrophages. J Exp Med 1987;166:1144-9.
14. Yoshioka M, Shapshak P, Sun NCJ, et al. Simultaneous detection of ferritin and HIV-1 in reactive microglia using combined immunohistochemistry and in situ hybridization. Acta Neuropathol 1992;84:297-306.
15. Shapshak P, Yoshioka M, Sun NCJ, Schiller PC. The use of combined in situ hybridization and immunocytochemistry to identify HIV-infected cells in brain tissue. Mod Pathol 1992;5:649-54.
16. Gendelman HE, Orenstein JM, Baca LM, et al. The macrophage in the persistence and pathogenesis of HIV infection. AIDS 1989;3: 475-95.
17. Ferrando S, van Gorp W, McElhiney M, Goggin K, Sewell M, Rabkin J. Highly active antiretroviral treatment in HIV infection: benefits for neuropsychological function. AIDS 1998;12:F65-F70.
18. Rolinski B, Bogner JR, Sadri I, et al. Absorption and elimination kinetics of zidovudine in the CSF in HIV-1 infected patients. J AIDS Hum Retroviruses 1997;15:192-7.
19. Erice A, Mayers DL, Strike DG, et al. Brief report: primary infection with zidovudine-resistant human immunodeficiency virus type 1. N Engl J Med 1993;328:1163-5.
20. Hecht FM, Grant RM, Petropoulis CJ, et al. Sexual transmission of an HIV-1 variant resistant to multiple reverse transcriptase and protease inhibitors. N Engl J Med 1998;339:307-11.