Corticosteroids reverse the inhibition of Na-glucose cotransport in the chronically inflamed rabbit ileum

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 276, Issue 1 39-1, 1999, Pages

  Sundaram, Uma ^a   Coon, Steve ^a   Wisel, Sheik ^a   West, A Brian ^b  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

Immune regulation of nutrient transport; Inflammatory bowel disease; Intestinal nutrient absorption; Sodium glucose cotransport

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CORTICOSTEROID; GLUCOSE; METHYLPREDNISOLONE; SODIUM ION;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC DISEASE; CONTROLLED STUDY; GLUCOSE TRANSPORT; HORMONAL REGULATION; ILEITIS; IMMUNOREGULATION; NONHUMAN; PRIORITY JOURNAL; RABBIT; SMALL INTESTINE ABSORPTION; SODIUM TRANSPORT; TRANSPORT KINETICS;

EID: 0032896362     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1999.276.1.g211     Document Type: Article

References (20)

1. Archampung, E. Q., J. Harris, and C. G. Clark. The absorption and secretion of water and electrolytes across the healthy and the diseased human colonic mucosa measured in vitro. Gut 13: 880-886, 1972.
2. Binder, H. J., and T. Ptak. Jejunal absorption of water and electrolytes in inflammatory bowel diseases. J. Lab. Clin. Med. 76: 915-924, 1970.
3. Castro, G. A. Immunological regulation of electrolyte transport. In: Textbook of Secretory Diarrhea, edited by E. Lebenthan and M. E. Duffey. New York. Raven, 1991, p. 31-46.
4. Forbush, B. Assay of Na-K-ATPase in plasma membrane preparations: increasing the permeability of membrane vesicles using sodium dodecyl sulphate buffered with bovine serum albumin. Anal. Biochem. 128: 159-163, 1983.
5. Hopfer, U. Membrane transport mechanisms for hexoses and amino acids in the small intestine. In: Physiology of the Gastrointestinal Tract (2nd ed.), edited by L. R. Johnson. New York: Raven, 1987, p. 1499-1526.
6. Kimmich, G. A. Intestinal absorption of sugars. In: Physiology of the Gastrointestinal Tract, edited by L. R. Johnson. New York: Raven, 1981, p. 1035-1061.
7. Nemirovsky, M. S., and J. S. Hugon. Immunopathology of guinea pig autoimmune enterocolitis induced by alloimmunization with an intestinal protein. Gut 27: 1434-1442, 1986.
8. Powell, D. W. Immunophysiology of intestinal electrolyte transport. In: Handbook of Physiology. The Gastrointestinal System. Intestinal Absorption and Secretion Bethesda, MD: Am. Physiol. Soc., 1990, sect. 6. vol. IV, chapt. 25, p. 591-641.
9. Rhoads, J. M., R. J. Macleod, and M. R. Hamilton. Effect of glucocorticoid on piglet jejunal mucosa during acute viral enteritis. Pediatr. Res. 23: 279-282, 1988.
10. Sandle, G. I., and H. J. Binder. Corticosteroids and intestinal ion transport. Gastroenterology 93: 188-196, 1987.
11. Sandle, G. I., J. P. Hayslett, and H. J. Binder. Effect of glucocorticoids on rectal transport in normal subjects and patients with ulcerative colitis. Gut 27: 309-316, 1986.
12. Sartor, R. B., W. J. Cromartie, D. W. Powell, and J. H. Schwab. Granulomatous enterocolitis induced in rats by purified bacterial cell wall fragments. Gastroenterology 89: 587-595, 1985.
13. Sellin, J. H., and M. Field. Physiologic and pharmacologic effects of glucocorticoids on ion transport across rabbit ileal mucosa in vitro. J. Clin. Invest. 67: 770-778, 1981.
14. 3 exchange in isolated crypt and villus cells. Am. J. Physiol. 260 (Gastrointest. Liver Physiol. 23): G440-G449, 1991.
15. Sundaram, U., and A. B. West. Effect of chronic inflammation on electrolyte transport in rabbit ileal villus and crypt cells. Am. J. Physiol. 272 (Gastrointest. Liver Physiol. 35): G732-G741, 1997.
16. Sundaram, U., S. Wisel, and J. J. Fromkes. Unique mechanism of Na-amino acid cotransport inhibition during chronic ileal inflammation. Am. J. Physiol. 275 (Gastrointest. Liver Physiol. 38): G483-G489, 1998.
17. Sundaram, U., S. Wisel, V. M. Rajendren, and A. B. West. Mechanism of inhibition of Na-glucose cotransport in the chronically inflamed rabbit ileum. Am. J. Physiol. 273 (Gastrointest. Liver Physiol. 36): G913-G919, 1997.
18. Sundaram, U., S. Wisel, S. Stengelin, W. Kramer, and V. Rajendran. Mechanism of inhibition of Na-bile acid cotransport during chronic ileal inflammation in rabbits. Am. J. Physiol. 275 (Gastrointest. Liver Physiol. 38): G1259-G1265, 1998.
19. Wright, E. M., B. A. Hirayama, D. D. F. Loo, E. Turk, and K. Hager. Intestinal sugar transport. In: Physiology of the Gastrointestinal Tract (3rd ed.), edited by L. R. Johnson. New York: Raven, 1994, p. 1751-1772.
20. + absorptive cell brush border Na:H exchange and association with an increase in message for NHE-3, an epithelial Na:H exchanger isoform. J. Biol. Chem. 268: 206-211, 1993.