Impaired glucocorticoid receptor function evolves in aberrant physiological responses to bacterial endotoxin

European Journal of Neuroscience

Volumn 11, Issue 1, 1999, Pages 178-186

  Reul, Johannes M H M ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

ACTH; Biotelemetry; Corticosterone; Interleukin 1; Interleukin 6; Tumour necrosis factor

Indexed keywords

COMPLEMENTARY RNA; CORTICOSTERONE; CORTICOTROPIN; ENDOTOXIN; GLUCOCORTICOID RECEPTOR; INTERLEUKIN 1BETA; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ARTICLE; BLOOD LEVEL; BODY TEMPERATURE; CIRCADIAN RHYTHM; CONTROLLED STUDY; CORTICOTROPIN BLOOD LEVEL; HORMONE RESPONSE; IMMUNE RESPONSE; INFLAMMATION; LOCOMOTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TELEMETRY; TRANSGENIC MOUSE;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; ANTISENSE ELEMENTS (GENETICS); BEHAVIOR, ANIMAL; BODY TEMPERATURE; CIRCADIAN RHYTHM; CORTICOSTERONE; INJECTIONS, INTRAPERITONEAL; INTERLEUKIN-1; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; LOCOMOTION; MALE; MICE; MICE, TRANSGENIC; NEUROSECRETORY SYSTEMS; PROMOTER REGIONS (GENETICS); RECEPTORS, GLUCOCORTICOID; SODIUM CHLORIDE; TRANSGENES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032895232     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.1999.00425.x     Document Type: Article

References (3)

1. Barden, N., Stec, I.S.M., Montkowski, A., Holsboer, F. & Reul, J.M.H.M. (1997) Endocrine profile and neuroendocrine challenge tests in transgenic mice expressing antisense RNA against the glucocorticoid receptor. Neuroendocrinology, 66, 212-220.
2. Chai, Z., Alheim, K., Lundkvist, J., Gatti, S. & Bartfai, T. (1996) Subchronic glucocorticoid pretreatment reversibly attenuates IL-1 beta induced fever in rats; IL-6 mRNA is elevated while IL-1 alpha and IL-1 beta mRNAs are suppressed, in the CNS. Cytokine, 8, 227-237.
3. Karanth, S., Linthorst, A.C.E., Stalla, G.K., Barden, N., Holsboer, F. & Reul, J.M.H.M. (1997) Hypothalamic-pituitary-adrenocortical axis changes in a transgenic mouse with impaired glucocorticoid receptor function. Endocrinology, 138, 3476-3485.