Synthesis and antitumor activities of water-soluble benzoylphenylureas

Chemical and Pharmaceutical Bulletin

Volumn 47, Issue 3, 1999, Pages 430-433

  Okada, Hiroshi ^a   Kato, Masanari ^a   Koyanagi, Tohru ^a   Mizuno, Kazuhiko ^b  

^a ISHIHARA SANGYO KAISHA LTD   (Japan)

^b Osaka Prefecture University   (Japan)

Author keywords

Amino acid; Antitumor agent; Benzoylphenylurea; Prodrug

Indexed keywords

AMINO ACID; ANTINEOPLASTIC AGENT; CARBANILAMIDE; PRODRUG; VINCA ALKALOID;

ANTINEOPLASTIC ACTIVITY; AQUEOUS SOLUTION; ARTICLE; BIOAVAILABILITY; DEPOLYMERIZATION; HUMAN; HUMAN CELL; INTRAVENOUS DRUG ADMINISTRATION; LEUKEMIA CELL; PROTON NUCLEAR MAGNETIC RESONANCE; SOLUBILITY; SYNTHESIS;

EID: 0032894077     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.47.430     Document Type: Article

References (11)

1. Schiff P. B., Fant J., Horwitz S. B., Nature (London), 277, 665-667 (1979).
2. Rowinsky E. K., Cazenave L. A., Donehower R. C., J. Natl. Cancer Inst., 82, 1247-1259 (1990).
3. Wilson L., Bamburg J. R., Mizel S. B., Grisham L. M., Creswell K. M., Fed. Proc., 33, 158-166 (1974).
4. Donoso J. A., Haskins K. M., Himes R. H., Cancer Res., 39, 1604-1610 (1979).
5. Okada H., Koyanagi T., Yamada N., Haga T., Chem. Pharm. Bull., 39, 2308-2315 (1991).
6. Okada H., Koyanagi T., Yamada N., Chem. Pharm. Bull., 42, 57-61 (1994). In this paper, we described the mode of action of benzoylphenylureas as the inhibition of DNA polymerase. However, we found that their activities on the inhibition of tubulin polymerization were higher than those of DNA polymerase (unpublished result).
7. Kondo N., Iwao T., Masuda H., Yamanouchi K., Ishihara Y., Yamada N., Haga T., Ogawa Y., Yokoyama K., Chem. Pharm. Bull., 41, 737-740 (1993).
8. a) Ohyama K., Kondo N., Kikuchi M., Esumi Y., Takaichi M., Kashiwazaki K., Kimura K., Xenobio. Metabol. and Dispos., 9, 423-436 (1994);
9. b) Ohyama K., Okada H., Kondo N., Kikuchi M., Esumi Y., Takaichi M., Kashiwazaki K., Kimura K., Okada Y., Sekine A., ibid., 9, 437-457 (1994);
10. c) Ohyama K., Kondo N., Esumi Y., Takaichi M., Kashiwazaki K., Kimura K., ibid., 9, 458-469 (1994);
11. d) Ohyama K., Okada H., Kondo N., Kikuchi M., Esumi Y., Takaichi M., Kashiwazaki K., Kimura K., Okada Y., Sekine A., ibid., 9, 470-481 (1994).