Irreversible glomerular lesions induced by crystal precipitation in a renal transplant after foscarnet therapy for cytomegalovirus infection

Histopathology

Volumn 34, Issue 4, 1999, Pages 365-369

  Justrabo, E ^c   Zanetta, G ^a   Martin, L ^d   Assem, M ^d   Mousson, C ^a   Maurice Estepa, L ^b   Rifle, G ^a   Tanter, Y ^a  

^a HÔPITAL DU BOCAGE   (France)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

^c UNIVERSITÉ DE BOURGOGNE   (France)

^d NONE

Author keywords

Cytomegalovirus infection; Electron microscopy; Glomerular crystals; Infrared analysis; Loscarnet; PCR in situ; Polarization examination; Renal transplantation

Indexed keywords

FOSCARNET;

ADULT; ARTICLE; CASE REPORT; CRYSTALLIZATION; CYTOMEGALOVIRUS INFECTION; DRUG SAFETY; GLOMERULOPATHY; GRAFT FAILURE; HUMAN; INFECTION PREVENTION; KIDNEY GRAFT; KIDNEY TRANSPLANTATION; MALE; POLYMERASE CHAIN REACTION; POSTOPERATIVE INFECTION; PRIORITY JOURNAL; TREATMENT PLANNING;

BIOPSY; BIREFRINGENCE; CRYSTALLIZATION; CYTOMEGALOVIRUS INFECTIONS; FOSCARNET; HUMANS; KIDNEY DISEASES; KIDNEY GLOMERULUS; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED;

CYTOMEGALOVIRUS;

EID: 0032893278     PISSN: 03090167     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2559.1999.00642.x     Document Type: Article

References (16)

1. 1. Wagstaff AJ, Bryson HM. Foscarnet. A reappraisal of its antiviral activity, pharmacokinetic properties and therapeutic use in immunocompromised patients with viral infection. Drugs 1994; 48; 199-226.
2. 2. Lehoang P, Girard B, Robinet M et al. Foscarnet in the treatment of cytomegalovirus retinitis in acquired immune deficiency syndrome. Ophthalmology 1989; 96; 865-874.
3. 3. Becker BN, Schulman G. Nephrotoxicity of antiviral therapies. Curr. Opin. Nephrol. Hypert. 1996; 5; 375-379.
4. 4. Beautils H, Deray G, Katlama C et al. Foscarnet and crystals in glomerular capillary lumens. Lancet 1990; 336; 755.
5. 5. Trolliet P, Dijoud F, Cotte L et al. Crescentic glomerulonephritis and crystals within glomerular capillaries in an AIDS patient treated with foscarnet. Am. J. Nephrol. 1995; 15; 256-259.
6. 6. Zanetta G, Maurice-Estepa L, Mousson C et al. Foscarnet-induced crystalline glomerulonephritis with nephrotic syndrome and acute renal failure after kidney transplantation. Transplantation (in press).
7. 7. Maurice-Estepa L, Hennequin C, Marfisi C, Bader C, Lacour B. Daudon M. Fourier Transform infrared microscopy identification of crystal deposits in tissues. Am. J. Clin. Pathol. 1996; 105; 576-582.
8. 8. Ray RA, Smith M, Sim R, Nystrom M, Pounder RF, Wakefield AJ, The intracellular polymerase chain reaction for small CMV genomic sequences within heavily infected cellular sections. J. Pathol. 1995; 177; 171-180.
9. 9. Mougin C, Didier JM, Bettinger D, Madoz L, Coumes-Marquet S, Lab M. In situ PCR to cells and to wax sections. Method. Mol. Biol. 1997; 71; 77-97.
10. 10. Navarro JF, Quereda C, Quereda C, et al. Nephrogenic diabetes insipidus and renal tubular acidosis secondary to foscarnet therapy. Am. J. Kidney Dis. 1996; 27; 431-434.
11. 11. Deray G, Martinez F, Katlama C et al. Foscarnet nephrotoxicity: mechanism, incidence and prevention. Am. J. Nephrol. 1989; 9; 316-321.
12. 12. Nyberg G, Svalander C, Blohme I, Persson H. Tubulointerstitial nephritis caused by the antiviral agent foscarnet. Transpl. Int. 1989; 2; 223-227.
13. 13. Nyberg G, Blohme I, Persson H, Svalander C, Foscarnet-induced tubulointerstitial nephritis in renal transplant patients. Transpl. Proc. 1990; 22; 2410.
14. 14. Morales JM, Munoz MA, Fernandez Zatarain G, Garcia Canton C, Garcia Rubiales MA, Andrès A. Reversible acute renal failure caused by the combined use of foscarnet and cyclosporin in organ transplant patients. Nephrol. Dial. Transpl. 1995; 10; 882-883.
15. 15. Gubler MC, Antignac C, Niaudet P, Broyer M. La biopsie rénale dans les maladies héréditaires métaboliques. In: Droz D, Lantz B, eds. La Biopsie Rénale. Paris: Editions INSERM. 1996; 421-439.
16. 16. Porus HJG, Grishman E, Alter AA, Mandelbaum H, Churg J. Paraproteinemia and cryoglobulinemia associated with atypical glomerulonephritis and the nephrotic syndrome. Am. J. Med. 1969; 47; 957-66.