Induction of a graft-versus-leukemia reaction by cyclosporin A withdrawal as immunotherapy for leukemia relapsing after allogeneic bone marrow transplantation

Bone Marrow Transplantation

Volumn 23, Issue 8, 1999, Pages 771-777

  Elmaagacli, A H ^b   Beelen, D W ^a   Trenn, G ^a   Schmidt, O ^a   Nahler, M ^a   Schaefer, U W ^a  

^a Department of Internal Medicine ^*

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

BMT; Cyclosporin A; Immunotherapy; Relapse

Indexed keywords

BCR ABL PROTEIN; CYCLOSPORIN A; MESSENGER RNA;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; ALLOGENIC BONE MARROW TRANSPLANTATION; ARTICLE; CANCER RECURRENCE; CANCER REGRESSION; CHROMOSOME 11Q; CHRONIC MYELOID LEUKEMIA; CLINICAL ARTICLE; CYTOGENETICS; DRUG WITHDRAWAL; FEMALE; GRAFT VERSUS HOST REACTION; GRAFT VERSUS LEUKEMIA EFFECT; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; IMMUNOTHERAPY; LEUKEMIA; MALE; PERIPHERAL BLOOD STEM CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; RETROSPECTIVE STUDY;

EID: 0032892990     PISSN: 02683369     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bmt.1701672     Document Type: Article

References (26)

1. Beelen DW, Quabeck K, Kaiser B et al. Six weeks of continuous intravenous cyclosporine and short course methotrexate as propyhlaxis for acute graft-versus-host disease after allogeneic bone marrow transplantation. Transplantation 1990; 50: 421-427.
2. Collins RH, Rogers ZR, Bennet M et al. Hematologic relapse of chronic myelogenous leukemia following allogeneic bone marrow transplantation: apparent graft-versus leukemia effect following abrupt discontinuation of immunsuppression. Bone Marrow Transplant 1992; 10: 391-395.
3. Kolb H, Mittermüller J, Clemm C et al. Donor leucocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients. Blood 1990; 76: 2462-2465.
4. Porter D, Roth M, McGarigle C et al. Induction of graft-versus-host disease as immunotherapy for relapsed chronic myeloid leukemia. New Engl J Med 1994; 330: 100-106.
5. Drobyski WR, Keever CA, Roth MS et al. Salvage immunotherapy using donor leukocyte infusions as treatment for relapsed chronic myelogenous leukemia after allogeneic bone marrow transplantation: efficacy and toxicity of a defined T-cell dose. Blood 1993; 82: 2310-2318.
6. Frassoni F, Sessarego M, Bacigalupo A et al. Competition between recipient and donor cells after bone marrow transplantation for chonic myeloid leukemia. Br J Haematol 1988; 69: 471-475.
7. Odom L, Githers J, Morse H et al. Remission of relapsed leukemia during graft-versus-host reaction. A graft-versus-leukemia reaction in man? Lancet 1988; 2: 537-540.
8. Petersen FB, Appelbaum FR, Bigelow CL et al. High-dose cytosine arabinoside, total body irradiation and marrow transplantation for advanced malignant lymphoma. Bone Marrow Transplant 1989; 4: 483-488.
9. Higano CS, Brixey M, Bryant EM et al. Durable complete remission of acute nonlymphocytic leukemia associated with discontinuation of immunosuppression following relapse after allogeneic bone marrow transplantation. A case report of a probable graft-versus-leukemia effect. Transplantation 1990; 50: 175-177.
10. Roth MS, Antin JH, Bingham EL, Ginsburg D. Detection of Philadelphia chromosome-positive cells by the polymerase chain reaction following bone marrow transplant for chronic myelogenous leukemia. Blood 1989; 74: 882-885.
11. Sayer HG, Beelen DW, Quabeck K et al. Comparison of high-dose busulfan and total-body irradiation prior to allogeneic bone marrow transplantation. In: Büchner T, Hiddemann W, Wörmann B (eds). Acute Leukemias IV, Prognostic Factors and Treatment Strategies. Haematology and Blood Transfusion. Springer Verlag: Berlin, 1994, pp 689-696.
12. Thomas ED, Storb R, Clift RA et al. Bone marrow transplantation. New Engl J Med 1975; 292: 895-902.
13. Maniatis T, Fritsch EF, Sambrook J. Molecular Cloning. A Laboratory Manual. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, 1982.
14. Elmaagacli AH, Beelen DW, Becks HW et al. Molecular studies of chimerism and minimal residual disease after allogeneic peripheral blood progenitor cell or bone marrow transplantation. Bone Marrow Transplant 1996; 18: 397-403.
15. Chomczynski P, Sacchi N. Single step method of RNA isolation by acid guanidium thiocyanate phenol chloroform extraction. Anal Biochem 1987; 162: 156-159.
16. Repp R, Borkhardt A, Haupt E et al. Detection of four different 11q23 chromosomal abnormalities by multiplex-PCR and fluorescence-based automatic DNA-fragment analysis. Leukemia 1995; 9: 210-216.
17. Kaplan EL, Meier P. Non-parametric estimation fron incomplete observations. J Am Stat Assoc 1958; 53: 457-481.
18. Elmaagacli AH, Beelen DW, Schaefer UW. A retrospective single centre study of the outcome of five different therapy approaches in 48 patients with relapse of chronic myelogenous leukemia after allogeneic bone marrow transplantation. Bone Marrow Transplant 1997; 20: 1045-1055.
19. Kosugi A, Shearer GM. Effect of cyclosporin A on lymphopoiesis. III. Augmentation of the generation of natural killer cells in bone marrow transplanted mice treated with cyclosporin A. J Immunol 1991; 146: 1416-1421.
20. Brooks EG, Wirt DP, Klimpel GR et al. In vivo and in vitro suppression of T-cell receptor alpha/beta CD4-CD8 T-lymphocytes by cyclosporine A. Clin Immunol Immunopathol 1993; 67: 224-228.
21. Charak BS, Agah R, Mazumder A. Synergism of interleukin-2 and cyclosporine A in induction of a graft-versus-tumor effect without graft-versus-host disease after syngeneic bone marrow transplantation. Blood 1992; 80: 179-184.
22. Arcese W, Goldman JM, D'Arcangelo E et al for the Chronic Leukemia Working Party of the European Bone Marrow Transplanation Group. Outcome for patients who relapse after allogeneic bone marrow transplantation for chronic myeloid leukemia. Blood 1993; 82: 3211-3219.
23. Higano CS, Raskind WH, Singer JW. Use of alpha interferon for the treatment of relapse of chronic myelogenous leukemia in chronic phase after allogeneic bone marrow transplantation. Blood 1992; 80: 1437-1442.
24. van Rhee F, Lin F, Cullis JO et al. Relapse of chronic myeloid leukemia after allogeneic bone marrow transplant: the case for giving donor leukocyte transfusions before the onset of hematologic relapse. Blood 1994; 83: 3377-3383.
25. Bar BM, Schattenberg A, Mensink EJ et al. Donor leukocyte infusions for chronic myeloid leukemia relapsed after allogeneic bone marrow transplantation. J Clin Oncol 1993; 11: 513-519.
26. Mehta J, Powles R, Kulkarni S et al. Induction of graft-versus-host disease as immunotherapy of leukemia relapsing after allogeneic transplantation: single center experience of 32 adult patients. Bone Marrow Transplant 1997; 20: 129-135.