Significance of electron-dense deposits in the mitochondrial matrix of erythroid precursors in aplastic anaemia and myelodysplastic syndrome

British Journal of Haematology

Volumn 105, Issue 1, 1999, Pages 149-154

  Bessho, Fumio ^a   Ohnishi, Hiroaki ^a   Tabuchi, Ken ^a   Kobayashi, Miyuki ^a   Hayashi, Yasuhide ^a  

^a UNIVERSITY OF TOKYO HOSPITAL   (Japan)

Author keywords

Aplastic anaemia; Iron deposits; Mitochondria; Myelodysplastic syndrome; Ultrastructure

Indexed keywords

APLASTIC ANEMIA; ARTICLE; CASE REPORT; CELL ULTRASTRUCTURE; ERYTHROBLAST; FEMALE; HUMAN; IRON STORAGE; MALE; MITOCHONDRIAL MEMBRANE; PRESCHOOL CHILD; PRIORITY JOURNAL; SIDEROBLASTIC ANEMIA;

ADOLESCENT; ADULT; ANEMIA, APLASTIC; ERYTHROBLASTS; ERYTHROID PROGENITOR CELLS; FEMALE; HUMANS; MALE; MICROSCOPY, ELECTRON; MITOCHONDRIA; MYELODYSPLASTIC SYNDROMES; RETICULOCYTES;

EID: 0032892867     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2141.1999.01310.x     Document Type: Article

References (24)

1. Amcnomori. T., Tomonaga, M.. Jinnai, I., Soda, H., Nonaka, H., Matsuo, T., Yoshida, Y., Kuriyama. K.. Ichimaru, M. & Suematsu, T. (1987) Cytogenetic and cytogenetical studies on progenitor cells of primary acquired sideroblastic anemia (PASA): involvement of multipotent myeloid stem cells'in PASA clone and mosaicism with normal clone. Blood, 70, 1367-1372.
2. Bader-Meunier. B., Mielot, F., Tchernia. G., Buisine, ]., Delsol, G., Duchayne, E., Lemerle, S., Leverger, G., De Lumley, L., Manel, A-M., Nathanson, M., Plantaz, D., Robert, A., Schaison, G., Sommelet, D. & Vilmer, E. (1996) Myelodysplastic syndromes in childhood: report of 49 patients from a French multicentre study. French Society of Paediatric Haematology and Immunology. British Journal of Uaematology. 92, 344-350.
3. Bennett, J.M., Catovsky, D., Daniel, M.T., Flandrin, G., Galton, D.A.G., Gralnick, U.R. & Sultan, C. (1982) Proposals for the classification of the myelodysplastic syndromes. British Journal of llaematology. 51, 189-199.
4. Bessho, F., Fujiu, M. & Kinumaki, H. (1981) Acute nonlymphocytic leukemia showing abnormal nuclear lobulation. American Journal of Clinical Pathology. 75, 684-692.
5. Cartwright, G.E. & Deiss, A. (1975) Sideroblasts, siderocytes, and sideroblastic anemia. New England Journal of Medicine, 292, 185-193.
6. de Planque, M.M.. Kluin-Nelemans, H.C., van Krieken, H.J., Kluin, P.M., Brand, A., Beverstock, G.C.. Willemze, R. & van Rood. J.J. (1988) Evolution of acquired severe aplastic anaemia to myelodysplasia and subsequent leukaemia in adults. British Journal of llaematology. 70, 55-62.
7. Gattermann, N.. Aul, C. & Schneider, W. (1993) Is acquired idiopathic sideroblastic anemia (AISA) a disorder of mitochondrial DNA? leukemia. 7, 2069-2076.
8. Geary. C.G., Marsh, J.CAV. & Gordon-Smith, B.C. (1996) Hypoplastic myelodysplasia (MDS). British Journal of Haematology. 94, 582-583.
9. Geraedts. J.P.M.. Weber, R.F.A.. Kerkhofs. H. & Leeksma. C.H.W. (1980) The preleukemic syndrome. H. Cytogenetic findings. Acta Medica Scandinavica. 207, 447-454.
10. Greenberg. P., Cox, C., LeBeau, M.M.. Fenaux, P., Morel, P., Sanz, G., Vallespi, T., Hamblin, T., Oscier, D., Ohyashiki, K., Toyama, K., Aul, C., Ghulam, M. & Bennett, J. (1997) International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood, 89, 2079-2088.
11. Haas. O.A. & Gadner, H. (1996) Pathogenesis, biology, and management of myelodysplastic syndromes in children. Seminars in Hematologij. 33, 225-235.
12. Hofmann, W.K., Ottmann, O.G., Ganser, A. & Hocker, D. (1996) Myelodysplastic syndromes: clinical features. Seminars in Hematology. 33, 177-185.
13. Hows, J.M. (1991) Severe aplastic anaemia: the patient without an HLA-identical sibling. British Journal of Haematology, 77, 1-4.
14. Imashuku, S., Hibi. S., Kataoka-Morimoto, Y., Yoshihara, T., Ikushima, S., Morioka, Y. & Todo. S. (1995) Myelodysplasia and acute myeloid leukaemia in cases of aplastic anaemia and congenital neutropenia following G-CSF administration. British Journal of Hnematologij. 89, 188-190.
15. Jackson, G.H., Carey, P.J.. Cant, A.J., Down, N.P. & Reid, M.M. (1992) Myelodysplastic syndromes in children. British Journal of Haematology. 80. 185-186.
16. Juneja, S.K., Imbert, M.. Sigaux, F., Jouault, H. & Sultan, C. (1983) Prevalence and distribution of ringed sideroblasts in primary myelodysplastic syndromes. Journal of Clinical Pathology. 36, 566-569.
17. Kojima, S., Tsuchida, M. & Matsuyama, T. (1992) Myelodysplasia and leukemia after treatment of aplastic anemia with G-CSF. New England Journal of Medicine, 326, 1294-1295.
18. Miller, D.R. (1995) Erythropoiesis, hypoplastic anemias, and disorders of heme synthesis. Blood Diseases of Infancy and Childhood, 7th edn (ed. by D. R. Miller and R. L. Baehner), pp. 140-192.
19. Ohara. A., Kojima, S., Hamajima, N., Tsuchida, M., Imashuku, S., Ohta, S., Sasaki, IL, Okamura, J.. Sugita, K.. Kigasawa. H., Kiriyama. Y., Akatsuka. J. & Tsukimoto, I. (1997) Myelodysplastic syndrome and acute myelogenous leukemia as a late clonal complication in children with acquired aplastic anemia. Blood, 90, 1009-1013.
20. Socie, G., Henry-Amar, M., Bacigalupo, A., Hows, J., Tichelli. A., Ljungman, P., McCann, S.R., Frickhofen, N., Van't Veer-Korthof. E. & Gluckman. E. (1993) Malignant tumors occurring after treatment of aplastic anemia. European Bone Marrow Transplantation-Severe Aplastic Anaemia Working Party. New England Journal of Mediane, 329,1152-1157.
21. Tichelli, A., Gratwohl. A.. Wursch, A., Nissen. C, & Speck. B. (1988) Late haematological complications in severe aplastic anaemia. British Journal of Haematology. 69, 413-418.
22. Tuzuner, N., Cox, C., Rowe, J.M., Watrous, D. &Bennett, J.M. (1995) Hypocellular myelodysplastic syndromes (MDS): new proposals. British Journal of llaematologu, 91, 612-617.
23. Young, N.S. (1992) The problem of clonality in aplastic anemia: Dr Dameshek's riddle, restated. Blood, 79, 1385-1392.
24. Zarco, M.A., Feliu, E., Rozman, C., Masat, T., Aymerich. M., Jou, J.M., Aguilar. J.L. & Vives Corrons, J.L. (1991) Ultrastructural study of erythrocytes containing Pappenheimer bodies in a case of congenital sideroblastic anaemia (CSA). British Journal of Haematology. 78, 577-578.