Role of thromboxane in the altered vascular reactivity of pregnant rats with adriamycin nephropathy

Nephrology Dialysis Transplantation

Volumn 14, Issue 5, 1999, Pages 1124-1128

  Mandelbaum, Alexander ^b   Podjarny, Eduardo ^b   Bernheim, Jacques ^a   Green, Janice ^b   Rathaus, Mauro ^b  

^a MEIR MEDICAL CENTER   (Israel)

^b NONE

Author keywords

Daltroban; Mesenteric arteries; Thromboxane receptor antagonists

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; DALTROBAN; DOXORUBICIN; NORADRENALIN; PROSTAGLANDIN H2; THROMBOXANE; THROMBOXANE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY BLOOD FLOW; ARTICLE; BLOOD VESSEL REACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; HYPERTENSION; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY DISEASE; MATERNAL HYPERTENSION; MESENTERIC ARTERY; NONHUMAN; PRIORITY JOURNAL; RAT; VASOCONSTRICTION;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; FEMALE; KIDNEY DISEASES; MESENTERIC ARTERIES; NOREPINEPHRINE; PHENYLACETATES; PREGNANCY; PREGNANCY COMPLICATIONS; RATS; RATS, WISTAR; RECEPTORS, THROMBOXANE; SULFONAMIDES; THROMBOXANES; VASCULAR RESISTANCE; VASOCONSTRICTOR AGENTS;

EID: 0032892752     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/14.5.1124     Document Type: Article

References (19)

1. Aalkjaer C, Danielsen H, Johannesen P, Pedersen EB, Rasmussen A, Mulvany MJ. Abnormal vascular function and morphology in pre-eclampsia: a study of isolated resistance vessels. Clin Sci 1985; 69: 477-482
2. Roberts JM, Taylor RN, Musci TJ, Rodgers GM, Hubei CA, McLaughlin MK. Preeclampsia: an endothelial cell disorder. Am J Obstet Gynecol 1989; 161: 1200-1204
3. Podjarny E, Bernheim JL, Rathaus M et al. Adriamycin nephropathy: a model to study the effects of pregnancy on renal disease in rat. Am J Physiol 1992; 263: F711-F715
4. Aoi W, Gable D, Clearly RE, Young PCM, Weinberger MH. The anti hypertensive effect of pregnancy in spontaneously hypertensive rats. Proc Soc Exp Biol Med 1976; 153: 13-15
5. Baylis C. Immediate and long term effects of pregnancy on glomerular function in the SHR. Am J Physiol 1989; 257: F1140-F1145
6. Lunjblad U, Karlsson K, Lundgren Y. The effect of pregnancy on heart size and blood pressure in renal hypertensive rats. Clin Exp Hyper Preg B 1983; 2: 61-74
7. Takeda T. Experimental study on blood pressure of pregnant hypertensive rats. 1. Effect of pregnancy on the course of experimentally and spontaneously hypertensive rats. Jap Circ J 1964; 28: 49-54
8. Leaker B, Becker GJ, El-Khativ M, Hewitson TD, Kinkaid-Smith PS. Repeated pregnancy does not accelerate glomerulosclerosis in rats with subtotal renal ablation. Clin Exp Hyper Preg B 1992; 11: 1-23
9. Rathaus M, Podjarny E, Pomeranz A et al. Adriamycin related hypertension in pregnant rats: response to a thromboxane receptor antagonist. Clin Sci 1995; 88: 623-627
10. Rathaus M, Podjarny E, Benchetrit S et al. Nitric oxide and vascular reactivity in pregnant rats with adriamycin nephropathy. Clin Sci 1997; 93: 227-234
11. Baylis C, Reckelhoff JF. Renal hemodynamics in normal and hypertensive pregnancy: lessons from micropuncture. Am J Kidney Dis 1991; 17: 98-104
12. Gonen O, Rathaus M, Pomeranz A, Podjarny E, Bernheim J. Increased sensitivity to angiotensin II in pregnant rats with adriamycin nephropathy (Abstract). Proceedings of the XXXth Congress of the EDTA-ERA, Glasgow 1993
13. Lumley P, White BP, Humphrey PP. GR32191, a highly potent and specific thromboxane A2 receptor blocking drug on platelets and vascular and airways smooth muscle in vitro. Br J Pharmacol 1989; 97: 783-794
14. 2+ concentrations. Thromb Res 1994; 75: 233-242
15. Hodgson WC, King RG, Boura-AL. Augmented potentiation of renal vasoconstrictor responses by thromboxane A2 receptor stimulation in the alloxan-diabetic rat. J Pharm Pharmacol 1990; 42: 423-427
16. Boussairi EH, Sacquet J, Benzoni D, Sassard J. Blood pressure effects of thromboxane A2 blockade in spontaneously hypertensive rats. Clin Exp Pharmacol Physiol 1993; 20: 679-687
17. Fasciolo JC, Vargas L, Lama MC, Nolly H. Bradykinin-induced vasoconstriction of rat mesenteric arteries precontracted with noradrenaline. Br J Pharmacol 1990; 101: 344-348
18. Fitzgerald DJ, Rocki W, Murray R, Mayo G, Fitzgerald C. Thromboxane A2 synthesis in pregnancy induced hypertension. Lancet 1990; 335: 751-754
19. Schiff E, Peleg E, Goldenberg M et al. The use of aspirin to prevent pregnancy induced hypertension and lower the ratio of thromboxane A2 to prostacyclin in relatively high risk pregnancies. N Eng J Med 1989; 321: 351-357