Multiplicity of the H+-dependent transport mechanism of dipeptide and anionic β-lactam antibiotic ceftibuten in rat intestinal brush-border membrane

Journal of Pharmacology and Experimental Therapeutics

Volumn 289, Issue 1, 1999, Pages 66-71

  Iseki, Ken ^a   Sugawara, Mitsuru ^a   Sato, Kaori ^a   Naasani, Imad ^a,b   Hayakawa, Tomohisa ^a   Kobayashi, Michiya ^a   Miyazaki, Katsumi ^a  

^a HOKKAIDO UNIVERSITY HOSPITAL   (Japan)

^b CANCER CHEMOTHERAPY CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAM ANTIBIOTIC; CEFTIBUTEN; DIPEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANION TRANSPORT; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG UPTAKE; ENZYME SPECIFICITY; ENZYME SUBSTRATE; INTESTINE BRUSH BORDER; LIGAND BINDING; MEMBRANE VESICLE; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; RAT;

EID: 0032892523     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Boll M, Markovich D, Weber WM, Korte H, Daniel H and Murer H (1994) Expression cloning a cDNA from rabbit small intestine related to proton-coupled transport of peptides, β-lactam antibiotics and ACE-inhibitors. Pflueger's Arch 429:146-149.
2. Booth AG and Kenny AJ (1974) A rapid method for the preparation of microvilli from rabbit kidney. Biochem J 142:575-581.
3. Erickson RH, Gum JR Jr, Lindstron MM, McKean D and Kim YS (1995) Regional expression and dietary regulation of rat small intestinal peptide and amino acid transporter mRNAs. Biochem Biophys Res Commun 216:249-257.
4. Fei YJ, Kanai Y, Nussebergger S, Ganapathy V, Leibach FH, Romero MF, Singh SK, Boron WF and Hediger MA (1994) Expression cloning of a mammalian proton-coupled oligopeptide transporter. Nature (Lond) 368:563-566.
5. Ganapathy ME, Prasad PD, Mackenzie B, Ganapathy V and Leibach FH (1997) Interaction of anionic cephalosporins with the intestinal and renal peptide transporters PepT1 and PepT2. Biochim Biophys Acta 1324:296-308.
6. Hauser H, Howell K, Dawson RMC and Bowyer DE (1980) Rabbit small intestinal brush border membrane preparation and lipid composition. Biochim Biophys Acta 602:567-577.
7. +-coupled transport of p.o. cephalosporins via dipeptide carriers in rabbit intestinal brush-border membranes. J Pharmacol Exp Ther 247:235-241.
8. Iseki K, Yonemura K, Kikuchi T, Naasani I, Sugawara M, Kobayashi M, Kohri N and Miyazaki K (1998) Purification by ceftibuten-affinity chromatography and the functional reconstitution of oligopeptide transporter(s) in rat intestinal brush-border membrane. Biochim Biophys Acta 1370:161-168.
9. Kramer W, Gutjahr U, Kowaleski S and Girbig F (1993) Interaction of the orally active dianionic cephalosporin cefixime with the uptake system for oligopeptides and α-amino β-lactam antibiotics in rabbit small intestine. Biochem Pharmacol 46:542-546.
10. +/peptide transporter hPepT1. J Biol Chem 271:5430-5437.
11. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275.
12. Matsumoto S Saito H and Inui K (1994) Transcellular transport of oral cephalosporins in human intestinal epithelial cells, Caco-2: Interaction with dipeptide transport systems in apical and basolateral membranes. J Pharmacol Exp Ther 270: 498-503.
13. Miyamoto KI, Shiraga T, Monta K, Yamamoto H, Haga H, Taketani Y, Tamai I, Sai Y, Tsuji A and Takeda E (1996) Sequence, tissue distribution and developmental changes in rat intestinal oligopeptide transporter. Biochim Biophys Acta 1305:34-38.
14. Muranushi N, Hashimoto N and Hirano K (1995) Transport characteristics of S-1090, a new oral β-lactam, in rat intestinal brush-border membrane vesicles. Pharm Res 12:1488-1492.
15. Muranushi N, Horie K, Matsuda K and Hirano K (1994) Characteristics of ceftibuten uptake into Caco-2 cells. Pharm Res (NY) 11:1761-1765.
16. Naasani I, Sato K, Iseki K, Sugawara M, Kobayashi M and Miyazaki K (1995) Comparison of the transport characteristics of ceftibuten in rat renal and intestinal brush-border membranes. Biochim Biophys Acta 1231:163-168.
17. Oh DM, Sinko PJ and Amidon GL (1993) Characterization of the oral absorption of some β-lactams: Effect of the α-amino side chain group. J Pharm Sci 82:897-900.
18. + coupled until transport of aminocephalosporins via the dipeptide transport system in rabbit intestinal brush-border membranes. J Biol Chem 261:14130-14134.
19. +/peptide cotransporter mediating absorption of β-lactam antibiotics in the intestine and kidney. J Pharmacol Exp Ther 275:1631-1637.
20. + coupled transport of orally active cephalosporin lacking an α-amino group across brush-border membrane vesicles from rat small intestine. J Pharm Pharmacol 43:433-435.
21. +-dependent transport of L-glutamic acid in rat intestinal brush-border membrane. Biochim Biophys Acta 1370:252-258.
22. Sugawara M, Toda T, Iseki K, Miyazaki K, Shiroto H, Kondo Y and Uchino JI (1992) Transport characteristics of cephalosporin antibiotics across intestinal brush-border membrane in man, rat and rabbit. J Pharm Pharmacol 44:968-972.
23. Sugawara M, Toda T, Kobayashi M, Iseki K, Miyazaki K, Shiroto K, Uchino JI and Kondo Y (1993) The inhibitory effects of cephalosporin and dipeptide of ceftibuten uptake by human and rat intestinal brush-border membrane vesicles. J Pharm Pharmacol 46:680-684.
24. Swaan PW, Stehouwer MC and Tukker JJ (1995) Molecular mechanism for the relative binding affinity to the intestinal peptide carrier: Comparison of three ACE-inhibitors: Enarapril, enalaprilat, and lisinopril. Biochim Biophys Acta 1236: 31-38.
25. Terada T, Sato H, Mukai M and Inui K (1997) Recognition of β-lactam antibiotics by rat peptide transporters, PepT1 and PepT2, in LLC-PK1 cells. Am J Physiol 273:F706-F711.
26. +/peptide cotransporter and distribution of the transport activity in isolated rabbit intestinal epithelial cells. J Pharmacol Exp Ther 272: 63-69.
27. Tsuji A, Tamai I, Hirooka H and Terasaki T (1986) β-Lactam antibiotics and transport via the dipeptide carrier system across the intestinal brush-border membrane. Biochem Pharmacol 36:565-567.
28. Wenzel U and Thwaites DT (1995) Stereoselective uptake of β-lactam antibiotics by the intestinal peptide transporter. Br J Pharmacol 116:3021-3027.
29. Wenzel U, Gerbert I, Weintraut H, Weber WM, Clauss W and Daniel H (1996) Transport characteristics of differently charged cephalosporin antibiotics in oocyte expressing the cloned intestinal peptide transporter PepT1 and in human Caco-2 cells. J Pharmacol Exp Ther 277:831-839.