Adhesin expression in matched nasopharyngeal and middle ear isolates of nontypeable Haemophilus influenzae from children with acute otitis media

Infection and Immunity

Volumn 67, Issue 1, 1999, Pages 449-454

  Krasan, Graham P ^a,b   Cutter, David ^a,b   Block, Stan L ^c   St Geme III, Joseph W ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ST LOUIS CHILDREN S HOSPITAL   (United States)

^c Pediatric Research Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BACTERIUM ADHERENCE; BACTERIUM ISOLATE; BACTERIUM PILUS; CHILD; CHILDHOOD DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; HAEMOPHILUS INFLUENZAE; HUMAN; INFANT; NASOPHARYNX; NONHUMAN; OTITIS MEDIA; PRIORITY JOURNAL;

EID: 0032892453     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.67.1.449-454.1999     Document Type: Article

References (41)

1. Anderson, P., R. B. Johnston, Jr., and D. H. Smith, 1972. Human serum activity against Haemophilus influenzae type b. J. Clin. Investig. 51:31-38.
2. Barenkamp, S. J., and E. Leininger. 1992. Cloning, expression, and DNA sequence analysis of genes encoding nontypeable Haemophilus influenzae high-molecular-weight surface-exposed proteins related to filamentous hemagglutinin of Bordetella pertussis. Infect. Immun. 60:1302-1313.
3. Barenkamp, S. J., and J. W. St. Geme III. 1996. Identification of a second family of high-molecular-weight adhesion proteins expressed by nontypeable Haemophilus influenzae. Mol. Microbiol. 19:1215-1223.
4. Brinton, C. C., Jr., M. J. Carter, D. B. Derber, S. Kar, J. A. Kramarik, A. C. To, S. C. To, and S. W. Wood. 1989. Design and development of pilus vaccines for Haemophilus influenzae diseases. Pediatr. Infect. Dis. J. 8:S54-S61.
5. Connor, E. M., and M. R. Loeb. 1983. A hemadsorption method for detection of colonies of Haemophilus influenzae type b expressing fimbriae. J. Infect. Dis. 148:855-860.
6. Faden, H., L. Duffy, R. Wasielewski, J. Wolf, D. Krystofik, Y. Tung, and Tonawanda/Williamsville Pediatrics. 1997. Relationship between nasopharyngeal colonization and the development of otitis media in children. J. Infect. Dis. 175:1440-1445.
7. Geluk, F., P. P. Eijk, S. M. van Ham, H. M. Jansen, and L. van Alphen. 1998. The fimbria gene cluster of nonencapsulated Haemophilus influenzae. Infect. Immun. 66:406-417.
8. Gilsdorf, J. R., H. Y. Chang, K. W. McCrea, and L. O. Bakaletz. 1992. Comparison of hemagglutinating pili of Haemophilus influenzae type b with similar structures of nontypeable H. influenzae. Infect. Immun. 60:374-379.
9. Gilsdorf, J. R., K. W. McCrea, and C. F. Marrs. 1997. Role of pili in Haemophilus influenzae adherence and colonization. Infect. Immun. 65: 2997-3002.
10. Guerina, N. G., S. Langermann, H. W. Clegg, T. W. Kessler, D. A. Goodmann, and J. R. Gilsdorf. 1982. Adherence of piliated Haemophilus influenzae type b to human oropharyngeal cells. J. Infect. Dis. 146:564.
11. Harabuchi, Y., H. Faden, N. Yamanaka, L. Duffy, J. Wolf, D. Krystofik, and Tonawanda/Williamsville Pediatrics. 1994. Nasopharyngeal colonization with nontypeable Haemophilus influenzae and recurrent otitis media. J. Infect. Dis. 170:862-866.
12. Hultgren, S. J., S. Abraham, M. Caparon, P. Falk, J. W. St. Geme III, and S. Nomark. 1993. Pilus and nonpilus bacteria adhesins: assembly and function in cell recognition. Cell 73:887-901.
13. Krasan, G. P., and J. W. St. Geme III. Unpublished data.
14. Kroll, J. S., B. M. Loynds, and E. R. Moxon. 1991. The Haemophilus influenzae capsulation gene cluster: a compound transposon. Mol. Microbiol. 5:1549-1560.
15. Kroll, J. S., and E. R. Moxon. 1988. Capsulation and gene copy number of the cap locus of Haemophilus influenzae type b. J. Bacteriol. 170:859-864.
16. Loos, B. G., J. M. Bernstein, D. M. Dryja, T. F. Murphy, and D. P. Dickinson. 1989. Determination of the epidemiology and transmission of nontypeable Haemophilus influenzae in children with otitis media by comparison of total genomic DNA restriction fingerprints. Infect. Immun. 57:2751-2757.
17. Mason, E. O., Jr., S. L. Kaplan, B. L. Weidermann, E. P. Norrod, and W. A. Stenback. 1985. Frequency and properties of naturally occurring piliated strains of Haemophilus influenzae type b. Infect. Immun. 49:98-103.
18. McCrea, K. W., W. J. Watson, J. R. Gilsdorf, and C. F. Marrs. 1994. Identification of hifD and hifE in the pilus gene cluster of Haemophilus influenzae type b strain Eagan. Infect. Immun. 62:4922-4928.
19. McCrea, K. W., W. J. Watson, J. R. Gilsdorf, and C. F. Marrs. 1997. Identification of two minor subunits in the pilus of Haemophilus influenzae. J. Bacteriol. 179:4227-4731.
20. Murphy, T. F., J. M. Bernstein, D. M. Dryja, A. A. Campagnari, and M. A. Apicella. 1987. Outer membrane protein and lipooligosaccharide analysis of paired nasopharyngeal and middle ear isolates in otitis media due to nontypeable Haemophilus influenzae: pathogenic and epidemiological observations. J. Infect. Dis. 156:723-731.
21. Pichichero, M. E. 1984. Adherence of Haemophilus influence to human buccal and pharyngeal epithelial cells: relationship to piliation. J. Med. Microbiol. 18:107-116.
22. Pichichero, M. E., M. Loeb, P. Anderson, and D. H. Smith. 1982. Do pili play a role in pathogenicity of Haemophilus influenzae type b? Lancet ii:960-962.
23. Pittman, M. 1931. Variation and type specificity in the bacterial species Haemophilus influenzae. J. Exp. Med. 53:471-493.
24. Rubin, L. G., and J. W. St. Geme III. 1993. Role of lipooligosaccharide in virulence of the Brazilian purpuric fever clone of Haemophilus influenzae biogroup aegyptius for infant rats. Infect. Immun. 61:650-655.
25. Samuelson, A., A. Freyd, J. Jonasson, and A. A. Lindberg. 1995. Turnover of nonencapsulated Haemophilus influenzae in the nasopharynges of otitisprone children. J. Clin. Microbiol. 33:2027-2031.
26. Spinola, S. M., J. Peacock, F. W. Denny, D. L. Smith, and J. G. Cannon. 1986. Epidemiology of colonization by nontypeable Haemophilus influenzae in children: a longitudinal study. J. Infect. Dis. 154:100-109.
27. St. Geme, J. W., III, and S. Falkow. 1990. Haemophilus influenzae adheres to and enters cultured human epithelial cells. Infect. Immun. 58:4036-4044.
28. St. Geme, J. W., III, J. R. Gilsdorf, and S. Falkow. 1991. Surface structures and adherence properties of diverse strains of Haemophilus influenzae biogroup aegyptius. Infect. Immun. 59:3366-3371.
29. St. Geme, J. W., III, S. Falkow, and S. J. Barenkamp. 1993. High-molecular-weight proteins of nontypeable Haemophilus influenzae mediate attachment to human epithelial cells. Proc. Natl. Acad. Sci. USA 90:2875-2879.
30. St. Geme, J. W., III, and D. Cutter. 1996. Influence of pili, fibrils, and capsule on in vitro adherence by Haemophilus influenzae type b. Mol. Microbiol. 21:21-31.
31. St. Geme, J. W., III, D. Cutter, and S. J. Barenkamp. 1996. Characterization of the genetic locus encoding Haemophilus influenzae type b surface fibrils. J. Bacteriol. 178:6281-6287.
32. St. Geme, J. W., III, J. S. Pinkner, G. P. Krasan, J. Heuser, E. Bullitt, A. L. Smith, and S. J. Hultgren. 1996. Haemophilus influenzae pili are composite structures assembled via the HifB chaperone. Proc. Natl. Acad. Sci. USA 93:11913-11918.
33. St. Geme, J. W., III, V. V. Kumar, D. Cutter, and S. J. Barenkamp. 1998. Prevalence and distribution of the hmw and hia genes and the HMW and Hia adhesins among genetically diverse strains of nontypeable Haemophilus influenzae. Infect. Immun. 66:364-368.
34. Stull, T. L., P. M. Mendelman, J. E. Haas, M. A. Schoenborn, K. D. Mack, and A. L. Smith. 1984. Characterization of Haemophilus influenzae type b fimbriae. Infect. Immun. 46:787-796.
35. Tosi, M. F., D. C. Anderson, J. Barrish, E. O. Mason, Jr., and S. L. Kaplan. 1985. Effect of piliation on interactions of Haemophilus influenzae type b with human polymorphonuclear leukocytes. Infect. Immun. 47:780-785.
36. Turk, D. C. 1984. The pathogenicity of Haemophilus influenzae. J. Med. Microbiol. 18:1-16.
37. van Alpen, L. L. Geelen-van den Broek, L. Blaas, M. van Ham, and J. Dankert. 1991. Blocking of fimbria-mediated adherence of Haemophilus influenzae by sialyl gangliosides. Infect. Immun. 59:4473-4477.
38. van Alphen, L., J. Poole, and M. Overbeeke. 1986. The Anton blood group antigen is the erythrocyte receptor for Haemophilus influenzae. FEMS Microbiol. Lett. 37:69-71.
39. van Ham, S. M., L. van Alphen, F. R. Mooi, and J. P. van Putten. 1993. Phase variation of H. influenzae fimbriae: transcriptional control of two divergent genes through a variable combined promoter region. Cell 73:1187-1196.
40. van Ham, S. M. L., van Alphen, F. R. Mooi, and J. P. van Putten. 1994. The fimbrial gene cluster of Haemophilus influenzae type b. Mol. Microbiol. 13:673-684.
41. Watson, W. J., J. R. Gilsdorf, M. A. Tucci, K. W. McCrea, L. J. Forney, and C. F. Marrs. 1994. Identification of a gene essential for piliation in Haemophilus influenzae type b with homology to the pilus assembly platform genes of gram-negative bacteria. Infect. Immun. 62:468-475.