Mineralization of glutaraldehyde-fixed porcine aortic valve cusps in the subcutaneous rat model: Analysis of variations in implant site and cuspal quadrants

Journal of Biomedical Materials Research

Volumn 45, Issue 3, 1999, Pages 209-213

  Mako, W John ^a   Shah, Amrik ^a   Vesely, Ivan ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Aortic valve; Calcification; Porcine; Subcutaneous implant

Indexed keywords

ABSORPTION SPECTROSCOPY; CERAMIC MATERIALS; IMPLANTS (SURGICAL); MATHEMATICAL MODELS; PROSTHETICS; TISSUE;

GLUTARALDEHYDE FIXED PORCINE AORTIC VALVE; SPRAGUE-DAWLEY RATS; SUBCUTANEOUS RAT MODEL;

CALCIFICATION (BIOCHEMISTRY);

CALCIUM; GLUTARALDEHYDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA VALVE PROSTHESIS; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; BIOPROSTHESIS; CALCIFICATION; CONTROLLED STUDY; MALE; MINERALIZATION; NONHUMAN; PROSTHESIS FAILURE; RAT; SWINE; TISSUE FIXATION;

EID: 0032892386     PISSN: 00219304     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4636(19990605)45:3<209::AID-JBM8>3.0.CO;2-N     Document Type: Article

References (25)

1. Schoen FJ, Collins JJ, Cohn LH. Long term failure rate and morphologic correlations in porcine bioprosthetic heart valves. Am J Cardiol 1983;51:957-964.
2. Milano A, Bortolotti U, Talenti E, Valfre C, Arbustini E, Valente M, Mazzucco A, Gallucci V, Theine G. Calcific degeneration as the main cause of porcine bioprosthetic valve dysfunction. Am J Cardiol 1984;53(8):1066-1070.
3. Schoen FJ. Cardiac valve prostheses: Review of clinical status and contemporary biomaterial issues. J Biomed Mater Res 1987;21(A1):91-117.
4. Levy RJ, Schoen FJ, Golomb G. Bioprosthetic heart valve calcification: Clinical features, pathobiology, and prospects for prevention. CRC Crit Rev Biocompat 1986;2(2):147-187.
5. Rose AG, Forman R, Bowen RM. Calcification of glutaraldehyde-fixed porcine xenograft. Thorax 1978;33:111-114.
6. Schoen FJ, Levy RJ. Pathology of substitute heart valves: New concepts and developments. J Cardiovasc Surg 1994;9:222-227.
7. Moore MA, Bobachevsky IK, Cheung DT, Boyan BD, Chen W-M, Bickers RR, Mcllroy BK. Stabilization of pericardial tissue by dye-mediated photooxidation. J Biomed Mater Res 1994;28:611-618.
8. Jonas RA, Ziemer G, Britton L, Armiger LJ. Cryopreserved and fresh antibiotic-sterilized valved aortic homograft conduits in a long-term sheep model - Hemodynamic, angiographic, and histologic comparisons. Thorac Cardiovasc Surg 1988;96:746-755.
9. Myers DJ, Nakaya G, Girardot M-N, Christie GW. A comparison between glutaraldehyde and diepoxide-fixed stentless porcine aortic valves: Biochemical and mechanical characterization and resistance to mineralization. J Heart Valve Dis 1995;4(I):S98-S101.
10. Grabenwoger M, Grimm M, Eybl E, Leukauf C, Muller MM, Plenck H Jr, Bock P. Decreased tissue reaction to bioprosthetic heart valve material after 1-glutamic acid treatment. A morphological study. J Biomed Mater Res 1992;26(9):1231-1240.
11. Schoen FJ, Levy RJ, Hilbert SL, Bianco RW. Antimineralization treatments for bioprosthetic heart valves. J Thorac Cardiovasc Surg 1992;104:1285-1288.
12. Vyavahare N, Hirsch D, Lerner E, Baskin JZ, Schoen FJ, Bianco R, Kruth HS, Zand R, Levy RJ. Prevention of bioprosthetic heart valve calcification by ethanol preincubation: Efficacy and mechanisms. Circulation 1997;95:479-188.
13. Chanda J. Posttreatment with amino compounds effective in prevention of calcification of glutaraldehyde-treated pericardium. Artif Organs 1994;18(5):408-410.
14. Hirsch D, Schoen FJ, Levy RJ. Effects of metallic ions and diphosphonates on inhibition of pericardial bioprosthetic tissue calcification and associated alkaline phosphatase activity. Biomaterials 1993;14(5):371-.
15. Bernacca GM, Dimitri WR, Fisher AC, Mackay TG, Wheatley DJ. Chemical modification of bovine pericardium and its effect on calcification in the rat subdermal model. Biomaterials 1992;13(6):345-352.
16. Liao K, Seifter E, Hoffman D, Yellin EL, Frater RWM. Bovine pericardium versus porcine aortic valve: Comparison of tissue biological properties as prosthetic valves. Artif Organs 1992;16(4):361-365.
17. Mako WJ, Vesely I. In vivo and in vitro models of calcification in porcine aortic valve cusps. J Heart Valve Dis 1997;6(3):316-323.
18. Vesely I, Marcis N, Dunmore PJ, Boughner D. The distribution and morphology of aortic valve cusp lipids. J Heart Valve Dis 1994;3(4):451-456.
19. Dunmore-Buyze J, Boughner DR, Macris N, Vesely I. A comparison of macroscopic lipid content within porcine pulmonary and aortic valves. Implications for bioprosthetic valves. J Thorac Cardiovasc Surg 1995;110(6):1756-1761.
20. Scott MJ, Vesely I. Morphology of porcine aortic valve cusp elastin. J Heart Valve Dis 1996;5:464-471.
21. Raggio CL, Boyan BD, Boskey AL. In vivo hydroxyapatite formation induced by lipids. J Bone Miner Res 1986;1(5):409-415.
22. Boyan BD, Schwartz Z, Swain LD, Khare A. Role of lipids in calcification of cartilage, The Anat Rec 1989;224:211-219.
23. Jorge-Herrero E, Fernandez P, de la Torre N, Escudero C, Garcia-Paez JM, Bujan J, Castillo-Olivareds JL. Inhibition of the calcification of porcine valve tissue by selective lipid removal. Biomaterials 1994;15(10):815-820.
24. Grossblatt N. Guide for the care and use of laboratory animals. Washington D.C.: National Academy Press; 1996. p 1-80.
25. Laird NM, Ware JH. Random-effects models for longitudinal data. Biometrics 1982;38:963-974.