Macrophage released proteoglycans are involved in cell-mediated aggregation of LDL

Atherosclerosis

Volumn 142, Issue 1, 1999, Pages 57-66

  Maor, Irit ^a   Aviram, Michael ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Aggregation; Atherosclerosis; Lipoproteins; Macrophages; Proteoglycans

Indexed keywords

ANGIOTENSIN; CHONDROITIN SULFATE; FERROUS SULFATE; HEPARAN SULFATE; LOW DENSITY LIPOPROTEIN; N ACETYLGALACTOSAMINE 4 SULFATASE; PHORBOL 13 ACETATE 12 MYRISTATE;

ANIMAL CELL; ARTICLE; ATHEROGENESIS; BACILLUS CEREUS; CELL AGGREGATION; CONTROLLED STUDY; LIPID PEROXIDATION; LIPOPROTEIN METABOLISM; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ISOLATION; PROTEOGLYCAN SYNTHESIS;

ANIMALS; CELL LINE; CHONDROITINASES AND CHONDROITIN LYASES; CULTURE MEDIA, CONDITIONED; GLYCOSAMINOGLYCANS; HEPARIN LYASE; HUMANS; LIPOPROTEINS, LDL; MACROPHAGES; MICE; PROTEOGLYCANS; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOMYELINS;

EID: 0032890453     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(98)00191-9     Document Type: Article

References (51)

1. Schaffner T.N., Taylor K., Bartucci E.J., Fischer-Dzoga J.H., Glagov S., Wissler R.W. Arterial foam cells with distinctive immunomorphologic and histochemical features of macrophages. Am J Pathol. 100:1980;57-80.
2. Aviram M. Modified forms of low density lipoprotein and atherosclerosis. Atherosclerosis. 98:1993;1-9.
3. Aviram M. Interaction of oxidized low density lipoprotein with macrophages in atherosclerosis and the antiatherogenicity of antioxidants. Eur J Clin Chem Clin Biochem. 34:1996;599-608.
4. Aviram M. Beyond cholesterol: Modifications of lipoproteins and increased atherogenicity. Neri Serneri G.G., Gensini G.F., Abbate R., Prisco D. Atherosclerosis, Inflammation and thrombosis. 1993;15-36 Scientific Press, Florence, Italy.
5. Hoff H.F., O'Neil J. Lesion-derived low density lipoprotein and oxidized low density lipoprotein share a lability for aggregation, leading to enhanced macrophage degradation. Arterioscler Thromb. 11:1991;1209-1222.
6. Khoo J.C., Miller E., McLoughlin P., Steinberg D. Enhanced macrophage uptake of low density lipoprotein after self-aggregation. Arteriosclerosis. 8:1988;348-358.
7. Suits A.G., Chait A., Aviram M., Heinecke J.W. Phagocytosis of aggregated lipoprotein by macrophages: low density lipoprotein receptor-dependent foam-cell formation. Proc Natl Acad Sci USA. 86:1989;2713-2717.
8. Heinecke J.W., Suits A.G., Aviram M., Chait A. Phagocytosis of lipase-aggregated low density lipoprotein promotes macrophage foam cell formation. Sequential morphological and biochemical events. Arterioscler Thromb. 11:1991;1643-1651.
9. Schissel S.L., Tweedi-Hardman J., Rapp J.H., Graham G., Williams K.J., Tabas I. Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein. Proposed role for arterial wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins. J Clin Investig. 98:1996;1455-1464.
10. 2+-induced oxidation. Biochem J. 310:1995;417-426.
11. Hoff H.F., Whitaker T.E., O'Neil J. Oxidation of low density lipoprotein leads to particle aggregation and altered macrophage recognition. J Biol Chem. 267:1992;602-609.
12. Lougheed M., Steinbrecher U.P. Mechanism of uptake of copper-oxidized low density lipoprotein in macrophages is dependent on its extent of oxidation. J Biol Chem. 20:1996;11798-11805.
13. Hoff H.F., O'Neil J. Structural and functional changes in LDL after modification with both 4-hydroxynonenal and malondialdehyde. J Lipid Res. 34:1993;1209-1217.
14. Maor I., Hayek T., Coleman R., Aviram M. Plasma LDL oxidation leads to its aggregation in the atherosclerotic apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Dis. 17:1997;2995-3005.
15. Tertov V.V., Sobenin I.A., Gabbasov Z.A., Popov E.G., Orekhov A.N. Lipoprotein aggregation as an essential condition of intracellular lipid accumulation caused by modified low density lipoproteins. Biochem Biophys Res Commun. 163:1989;489-494.
16. Tertov V.V., Sobenin I.A., Gabbasov Z.A., Popov E.G., Yaroslavov A.A., Jauhiainen M., Ehnholm C., Smirnov V.N., Orekhov A.N. Three types of naturally occurring modified lipoproteins induce intracellular lipid accumulation in human aortic intimal cells - the role of lipoprotein aggregation. Eur J Clin Chem Clin Biochem. 30:1992;171-178.
17. Aviram M., Rosenblat M. Macrophage-mediated oxidation of extracellular low density lipoprotein requires an initial binding of the lipoprotein to its receptor. J Lipid Res. 35:1994;385-398.
18. Aviram M., Rosenblat M., Etzioni A., Levy R. Activation of NADPH oxidase is required for macrophage-mediated oxidation of LDL. Metabolism. 45:1996;1069-1079.
19. Mitchinson M.J., Ball R.Y. Macrophages and atherogenesis. The Lancet. 18:1987;146-149.
20. Nathan C.F. Secretory products of macrophages. J Clin Investig. 79:1987;319-326.
21. Oiknine J., Aviram M. Increased susceptibility to activation and increased uptake of low density lipoprotein by cholesterol-loaded macrophages. Arterioscler Thromb. 12:1992;745-753.
22. Carter D., Fuhrman B., Aviram M. Macrophages activation with phorbol myristate acetate is associated with cellular lipid peroxidation. Isr J Med Sci. 32:1996;479-485.
23. Hurt E., Bondjers G., Camejo G. Interaction of LDL with human arterial proteoglycans stimulates its uptake by human monocyte-derived macrophages. J Lipid Res. 31:1990;443-454.
24. Hurt-Camejo E., Camejo G., Rosengren B., Lopez F., Ahlstrom C., Fager G., Bondjers G. Effect of arterial proteoglycans and glycosaminoglycans on low density lipoprotein oxidation and its uptake by human macrophages and arterial smooth muscle cells. Arterioscler Thromb. 12:1992;569-583.
25. Aviram M. Plasma lipoprotein separation by discontinuous density gradient ultracentrifugation in hyperlipoproteinemic patients. Biochem Med. 30:1983;111-118.
26. Lowry O.H., Rosebrough N.J., Farr A.L., Randell R. Protein measurement with the folin reagent. J Biol Chem. 193:1951;265-275.
27. Basu S., Goldstein J.L., Anderson W., Brown M.S. Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts. Proc Natl Acad Sci USA. 73:1976;3178-3182.
28. Colf S.B., Verheyden J. Electrophoresis and sudan black staining of lipoprotein on gelatinized cellulose acetate. Clin Chim Acta. 18:1967;325-326.
29. Vijayagopal P., Srinivasan S.R., Radhakrishnamurthy B., Berenson G.S. Interaction of serum lipoproteins and a proteoglycan from bovine aorta. J Biol Chem. 256:1981;8234-8241.
30. Owens R.T., Wanger W.D. Proteoglycans produced by cholesterol-enriched macrophages bind plasma low density lipoprotein. Atherosclerosis. 91:1991;229-240.
31. Edwards I.J., Xu H., Obunike J.C., Goldberg I.J., Wagner W.D. Differentiated macrophages synthesize a heparan sulfate proteoglycan and an oversulfated chondroitin sulfate proteoglycan that bind lipoprotein lipase. Arterioscler Thromb Vasc Biol. 15:1995;400-409.
32. Van de Lest C.H., Versteeg E.M., Veerkamp J.H., van Kuppevelt T.H. A spectrophotometric method for the determination of heparan sulfate. Biochim Biophys Acta. 1201:1994;305-311.
33. Bartlett G.R. Phosphorus assay in column chromatography. J Biol Chem. 234:1959;466-468.
34. Fuhrman B., Oiknine J., Aviram M. Iron induces lipid peroxidation in cultured macrophages, increases their ability to oxidatively modify LDL, and affects their secretory properties. Atherosclerosis. 111:1994;65-78.
35. Yeaman C., Rapraeger A.C. Membrane anchored proteoglycans of mouse macrophages: P388D1 cells express a syndecan-4-like heparan sulfate proteoglycan and a distinct chondroitin sulfate form. J Cell Physiol. 157:1993;413-425.
36. Christner J.E. Biosynthesis of chondroitin sulfate proteoglycan by P338D1 macrophage-like cell line. Arteriosclerosis. 8:1988;535-543.
37. Keidar S., Kaplan M., Hoffman A., Aviram M. Angiotensin II stimulates macrophage-mediated oxidation of low density lipoproteins. Atherosclerosis. 115:1995;201-215.
38. Hoff H.F., Gaubatz J.W. Isolation, purification and characterization of a lipoprotein containing Apo-B from the human aorta. Atherosclerosis. 42:1982;273-297.
39. Morton R.E., West G.A., Hoff H.F. A low density lipoprotein-sized particle isolated from human atherosclerotic lesions is internalized by macrophages via a non-scavenger receptor mechanism. J Lipid Res. 27:1986;1124-1134.
40. Frank J.S., Fogelman A.M. Ultrastructure of the intima in WHHL and cholesterol-fed rabbit aortas prepared by ultra-rapid freezing and freezetetching. J Lipid Res. 30:1989;967-978.
41. Aviram M., Maor I., Keidar S., Hayek T., Oiknine J., Bar-El Y., Adler Z., Kertzman V., Milo S. Lesioned low density lipoprotein in atherosclerotic apolipoprotein E-deficient transgenic mice and in humans is oxidized and aggregated. Biochem Biophys Res Commun. 216:1995;501-513.
42. Tabas I., Li Y., Brocia R.W., Xu S.W., Swenson T.L., Williams K.J. Lipoprotein lipase and sphingomyelinase synergistically enhance the association of atherogenic lipoproteins with smooth muscle cells and extracellular matrix. J Biol Chem. 268:1993;20419-20432.
43. Vijayagopal P., Srinivasan S.R., Radhakrishnamurthy B., Berenson G.S. Homeostatic properties and serum lipoprotein binding of a heparan sulfate proteoglycan from bovine aorta. Biochim Biophys Acta. 758:1983;70-83.
44. Camejo G., Rosengren B., Olson U., Lopez F., Olofson S.O., Westerlund C., Bondjers G. Molecular basis of the association of arterial proteoglycans with low density lipoproteins: its effect on the structure of the lipoprotein particle. Eur Heart J. 11:1990;164-173.
45. Camejo G., Olofsson S.O., Lopez F., Carlsson P., Bondjers G. Identification of Apo B-100 segments mediating the interaction of low density lipoproteins with arterial proteoglycans. Arteriosclerosis. 8:1988;368-377.
46. Camejo G., Hurt E., Wiklund O., Rosengren B., Lopez F., Bondjers G. Modifications of low-density lipoprotein induced by arterial proteoglycans and chondroitin-6 sulfate. Biochim Biophys Acta. 1096:1991;253-261.
47. Uhlin-Hansen L., Wik T., Kijellen L., Berg E., Forsdahl F., Kolset S.O. Proteoglycan metabolism in normal and inflammatory human macrophages. Blood. 82:1993;2880-2889.
48. Vijayagopal P., Figueroa J.E., Guo Q., Fontenot J.D., Tao Z. Marked alteration of proteoglycan metabolism in cholesterol-enriched human arterial smooth muscle cells. Biochem J. 315:1996;995-1000.
49. Wosu L., Parisella R., Kalant N. Effect of low density lipoprotein on glycosaminoglycan secretion by cultured human smooth muscle cells and fibroblasts. Influence of serum concentration and cell proliferation rate. Atherosclerosis. 48:1983;205-220.
50. Fuhrman B., Oiknine J., Keidar S., Ben-Yaish L., Kaplan M., Aviram M. Increased uptake of low density lipoprotein (LDL) by oxidized macrophages is the result of an initial enhanced LDL receptor activity and of a further progressive oxidation of LDL. Free Radic Biol Med. 23:1997;34-46.
51. Ljubuncic P., Fuhrman B., Oiknine J., Aviram M., Bomzon A. Effect of deoxycholic acid and ursodeoxycholic acid on lipid peroxidation in cultured macrophages. Gut. 39:1996;475-478.