Diverse gene junctions of respiratory syncytial virus modulate the efficiency of transcription termination and respond differently to M2- mediated antitermination

Journal of Virology

Volumn 73, Issue 1, 1999, Pages 170-176

  Hardy, Richard W ^a   Harmon, Shawn B ^a   Wertz, Gail W ^a  

^a University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RNA POLYMERASE; VIRUS PROTEIN; VIRUS RNA;

ARTICLE; CONTROLLED STUDY; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; REPLICON; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RNA SYNTHESIS; TRANSCRIPTION TERMINATION; VIRUS GENE; VIRUS TRANSCRIPTION;

EID: 0032889282     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.1.170-176.1999     Document Type: Article

References (15)

1. Barik, S. 1992. Transcription of human respiratory syncytial virus genome RNA in vitro: requirement of cellular factor(s). J. Virol. 66:6813-6818.
2. Barr, J. N., S. P. J. Whelan, and G. W. Wertz. 1997. cis-Acting signals involved in termination of vesicular stomatitis virus mRNA synthesis include the conserved AUAC and the U7 signal for polyadenylation. J. Virol. 71:8718-8725.
3. Barr, J. N., S. P. J. Whelan, and G. W. Wertz. 1997. Role of the intergenic dinucleotide in vesicular stomatitis virus RNA transcription. J. Virol. 71:1794-1801.
4. Cavanagh, D., and T. Barrett. 1988. Pneumovirus like characteristics of the mRNA and protein of turkey rhinotracheitis virus. Virus Res. 11:241-256.
5. Collins, P. L., L. E. Dickens, A. Buckler-White, R. A. Olmstead, M. K. Spriggs, E. Camargo, and K. V. W. Coelingh. 1986. Nucleotide sequences for the gene junctions of human respiratory syncytial virus reveal distinctive features of intergenic structure and gene order. Proc. Natl. Acad. Sci. USA 83:4594-4598.
6. Collins, P. L., M. G. Hill, J. Cristina, and H. Grosfeld. 1996. Transcription elongation factor of respiratory syncytial virus, a non-segmented negative-strand RNA virus. Proc. Natl. Acad. Sci. USA 93:81-85.
7. Collins, P. L., Y. T. Huang, and G. W. Wertz. 1984. Identification of a tenth mRNA of respiratory syncytial virus and assignment of polypeptides to the 10 viral genes. J. Virol. 49:572-578.
8. Collins, P. L., M. A. Mink, and D. S. Stec. 1991. Rescue of synthetic analogs of respiratory syncytial virus genomic RNA and effect of truncations and mutations on the expression of a foreign reporter gene. Proc. Natl. Acad. Sci. USA 88:9663-9667.
9. Collins, P. L., R. A. Olmstead, M. K. Spriggs, P. R. Johnson, and A. J. Buckler-White. 1987. Gene overlap and attenuation of transcription of the viral polymerase L gene of human respiratory syncytial virus. Proc. Natl. Acad. Sci. USA 84:5134-5138.
10. Collins, P. L., and G. W. Wertz. 1983. cDNA cloning and transcriptional mapping of nine polyadenylated RNAs encoded by the genome of human respiratory syncytial virus. Proc. Natl. Acad. Sci. USA 80:3208-3212.
11. Dickens, L. E., P. L. Collins, and G. W. Wertz. 1984. Transcriptional mapping of human respiratory syncytial virus. J. Virol. 52:364-369.
12. Fearns, R., M. E. Peeples, and P. L. Collins. 1997. Increased expression of the N protein of respiratory syncytial virus stimulates minigenome replication but does not alter the balance between the synthesis of mRNA and antigenome. Virology 236:188-201.
13. Freidman, D. I., and D. L. Court. 1995. Transcription antitermination: the λ paradigm updated. Mol. Microbiol. 18:191-200.
14. Grosfeld, H., M. Hill, and P. L. Collins. 1995. RNA replication by respiratory syncytial virus (RSV) is directed by the N, P, and L proteins; transcription also occurs under these conditions but requires RSV superinfection for efficient synthesis of full-length mRNA. J. Virol. 69:5677-5686.
15. Hardy, R. W., and G. W. Wertz. 1998. The product of the respiratory syncytial virus M2 gene ORF1 enhances readthrough of intergenic junctions during viral transcription. J. Virol. 72:520-526.