Three oral formulations of methadone: A clinical and pharmacodynamic comparison

Journal of Substance Abuse Treatment

Volumn 17, Issue 3, 1999, Pages 237-241

  Gourevitch, Marc N ^a,b   Hartel, Diana ^a   Tenore, Peter ^b   Freeman, Katherine ^a   Marion, Ira ^b   Hecht, Joe ^b   Lowinson, Joyce ^b  

^a MONTEFIORE MEDICAL CENTER   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Change intolerance; Formulation; Methadone; Pharmacodynamics; Withdrawal

Indexed keywords

METHADONE;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG HYPERSENSITIVITY; DRUG WITHDRAWAL; FEMALE; HEROIN DEPENDENCE; HUMAN; MALE; ORAL DRUG ADMINISTRATION; PHARMACODYNAMICS; PRIORITY JOURNAL; SYMPTOMATOLOGY;

ADULT; CHEMISTRY, PHARMACEUTICAL; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; METHADONE; MIDDLE AGED; NARCOTICS; OPIOID-RELATED DISORDERS; SUBSTANCE WITHDRAWAL SYNDROME; TREATMENT OUTCOME;

EID: 0032887764     PISSN: 07405472     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0740-5472(99)00008-2     Document Type: Article

References (7)

1. Ball J.C., Ross A. The effectiveness of methadone maintenance treatment. 1991;Springer-Verlag, New York.
2. Handelsman L., Cochrane K.J., Aronson M.J., Ness R., Rubinstein K.J., Kanof P.D. Two new rating scales for opiate withdrawal. American Journal of Drug and Alcohol Abuse. 13:1987;293-308.
3. Horns W.H., Rado M., Goldstein A. Plasma levels and symptom complaints in patients maintained on a daily dosage of methadone hydrochloride. Clinical Pharmacology and Therapeutics. 17:1975;363-649.
4. Peyser N.P., Friedman P., Damiani S., Goldsmith D.S., Petty W.G. Evaluation study of a computer-assisted pump used for liquid methadone dispensing. Journal of Maintenance in the Addictions. 1:1997;25-47.
5. Silver J.S., Shaffer H.J. Change intolerance to shifts in methadone formulation. A preliminary investigation Journal of Substance Abuse Treatment. 13:1996;331-339.
6. Steels M.D., Hamilton M., McLean P.C. The consequences of a change in formulation of methadone prescribed in a drug clinic. British Journal of Addiction. 87:1992;1549-1554.
7. Wolff K., Sanderson M., Hay A.W.M., Raistrick D. Methadone concentrations in plasma and their relationship to drug dosage. Clinical Chemistry. 37:1991;205-209.