The Study of the Anesthetic Action of Halothane on the Rat Spinal Cord by Fos Immunoreactivity

Japanese Journal of Anesthesiology

Volumn 48, Issue 9, 1999, Pages 975-976

  Fukada, Yusaku ^a   Otsuki, Manabu ^a   Tase, Choichiro ^a  

^a Department of Anesthesiology   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HALOTHANE; OXYGEN; PROTEIN C FOS;

ANESTHESIA; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; IMMUNOREACTIVITY; MINIMUM LUNG ALVEOLUS CONCENTRATION; NOCICEPTIVE STIMULATION; NONHUMAN; RAT; SPINAL CORD;

ANESTHESIA, INHALATION; ANESTHETICS, INHALATION; ANIMALS; BIOLOGICAL MARKERS; DOSE-RESPONSE RELATIONSHIP, DRUG; HALOTHANE; MALE; NEURONS; NOCICEPTORS; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; SYNAPTIC TRANSMISSION;

EID: 0032886976     PISSN: 00214892     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. de Jong RH, Wagman IH : Block of afferent impulses in the dosai horn of monkey. A possible mechanism of anesthesia. Exp Neurol 20 : 352, 1968
2. de Jong RH, Robles R, Morikawa K : Actions of halothane and nitrous oxide on dorsal horn neurons ("the spinal gate"). Anesthesiology 31: 205, 1969
3. de Jong RH, Robles R, Heavner JE : Suppression of impulse transmission in the cat's dorsal horn by inhalation anesthetics. Anesthesiology 32: 440, 1970
4. Kitahata LM, Ghazi-Saidai K, Yamashita M, et al : The depressant effect of halothane and sodium thiopental on the spontaneous and evoked activity of dorsal horn cells : Lamina specificity, time course and dose dependence. J Pharmacol Exp Ther 195: 515, 1975
5. Namiki A, Collins JG, Kitahata LM, et al : Effects of halothane on spinal neuronal responses to graded noxious heat stimulation in the cat. Anesthesiology 53: 475, 1980
6. Takenoshita M, Takahashi T : Mechanisms of halothane action on synaptic transmission in motoneurons of the newborn rat spinal cord in vitro. Brain Res 402: 303, 1987
7. Sugiyama K, Muteki T, Shimoji K : Halothaneinduced hyperpolarization and depression of postsynaptic potentials of guinea pig thalamic neurons in vitro. Brain Res 576: 97, 1992
8. Yamamori Y, Kishikawa K, Collins JG : Halothane effects on low-threshold receptive field size of rat spinal dorsal horn neurons appear to be independent of supraspinal modulatory systems. Brain Res 702 : 162, 1995
9. Quasha AL, Eger El II, Tinker JH : Determination and applications of MAC. Anesthesiology 53: 315, 1980
10. Hunt SP, Pini A, Evan G : Induction of c-foslike protein in spinal cord neurons following sensory stimulation. Nature 328: 632, 1987
11. Menêrey D, Gannon A, Levine JD, et al : Expression of c-fos protein in interneurons and projection neurons of the rat spinal cord in response to noxious somatic, articular, and visceral stimulation. J Comp Neurol 285: 177, 1989
12. Bullitt E : Expression of c-fos-like protein as a marker for neuronal activity following noxious stimulation in the rat. J Comp Neurol 296 : 517, 1990
13. Walzer PR, Baez S, Orkin LR : A method for determining minimum alveolar concentration of anesthetic in the rat. Anesthesiology 39: 394, 1973
14. Hsu S, Raine L, Fanger H : Use of avidinebiotin-peroxidase complex (ABC) in immunoperoxidase techniques : A comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 29: 577, 1981
15. Rexed B : The cytoarchitectonic organization of the spinal cord in the cat. J Comp Neurol 96 : 415, 1952
16. Molander C, XU Q, Grant G : The cytoarchitectonic organization of the spinal cord in the rat. I.The lower thoracic and lumbosacral cord. J Comp Neurol 230: 133, 1984
17. Franks NP, Lieb WR : Molecular and cellular mechanisms of general anaesthesia. Nature 367: 607, 1994
18. Roizen MF, Korrigan RW, Frazer BM : Anesthetic doses blocking adrenergic (stress) and cardiovascular responses to incision-MAC BAR. Anesthesiology 54 : 390, 1981
19. Chi SI, Levine JD, Basbaum AI: Effects of discharge on the persistent expression of spinal cord fos-like immunoreactivity produced by sciatic nerve transection in the rat. Brain Res 617: 220, 1993
20. Sun WZ, Shyu BC, Shieh JY : Nitrous oxide or halothane, or both, fail to suppress c-fos expression in rat spinal cord dorsal horn neurones after subcutaneous formalin. Br J Anaesth 76 : 99, 1996