Infiltration of lymphocytes in the limbic brain following stimulation of subclinical cellular immunity and low dosages of lithium and a cholinergic agent

Toxicology Letters

Volumn 109, Issue 1-2, 1999, Pages 77-85

  Cook, Lisa L ^a   Persinger, M A ^a  

^a LAURENTIAN UNIVERSITY   (Canada)

Author keywords

Cholinergic effects; Experimental allergic encephalomyelitis; Lithium; Lymphocytes; Markers and indicators; Subclinical effects

Indexed keywords

LITHIUM; MUSCARINIC AGENT; PILOCARPINE;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; FEMALE; HYPOTHESIS; IMMUNOSTIMULATION; INTRACEREBRAL DRUG ADMINISTRATION; LIMBIC CORTEX; LYMPHOCYTIC INFILTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CHOLINERGIC AGENTS; FEMALE; IMMUNITY, CELLULAR; LIMBIC SYSTEM; LITHIUM; LYMPHOCYTES; MALE; NEURONS; PARASYMPATHOMIMETICS; PILOCARPINE; RATS; RATS, INBRED LEW; SEIZURES;

ANIMALIA;

EID: 0032886886     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(99)00123-X     Document Type: Article

References (26)

1. Aihara N., Hall J.J., Pitts L.H., Fukuda K., Noble L.J. Altered immunoexpression of microglia and macrophages after mild head injury. J. Neurotraum. 12:1995;53-63.
2. Alvord E.C., Kies M.W., Suckling A.J. Experimental allergic encephalomyelitis: a useful model for multiple sclerosis. 1984;A.R. Liss, New York.
3. Bureau Y.R.J., Peredery O., Persinger M.A. Concordance of quantitative damage within the diencephalon and telencephalon following systemic pilocarpine (380 mg/kg) or lithium (3 mEq/kg)/pilocarpine (30 mg/kg) induced seizures. Brain. Res. 56:1994;225-235.
4. Calza L., Giardino L., Pozza M., Micera A., Aloe L. Time-course changes of nerve growth factor, corticotrophin-releasing hormone, and nitric oxide synthase isoforms and their possible role in the development of inflammatory response in experimental allergic encephalomyelitis. Proc. Natl. Acad. Sci. USA. 94:1997;3368-3373.
5. Cook L.L., Persinger M.A. Subclinical' dosages of lithium and pilocarpine that do not evoke overt seizures affect long-term spatial memory but not learning in rats. Percep. Mot. Skil. 86:1998;1288-1290.
6. Goldstein J.A. Chronic fatigue syndromes: the limbic hypothesis. 1993;Haworth Medical, Binghamton, NY.
7. Hines M.E., Kubu C.S., Roberts R.J., Varney N.R. Characteristics and mechanisms of epilepsy spectrum disorder: an explanatory model. Ap. Neuropsychol. 2:1995;1-6.
8. Honchar M.P., Olney J.S., Sherman W.R. Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats. Science. 220:1983;323-325.
9. Kwon E.E., Prineas J.W. Blood-brain barrier abnormalities in longstanding multiple sclerosis. An immunohistochemical study. J. Neuropath. Exp. Neurol. 53:1994;625-636.
10. Matthews W.B. McApline's multiple sclerosis. 2nd edn:1991;3-125 Livingtson, New York.
11. Missaghi B., Richards P.M., Persinger M.A. Severity of experimental allergic encephalomyelitis in rats depends upon the temporal contiguity between limbic seizures and inoculation. Pharmacol. Biochem. Behav. 43:1992;1081-1086.
12. Paxinos, G. (Ed.), 1985. The rat nervous system. Academic Press, Sydney, Australia.
13. Paxinos G., Watson C. The rat brain in stereotaxic coordinates. 2nd edition:1986;Academic Press, Sydney, Australia.
14. Persinger M.A. Brain mast cell numbers in the albino rat: source of variability. Behav. Neural. Biol. 25:1979;380-386.
15. Persinger M.A. Degranulation of brain mast cells in young albino rats. Behav. Neural. Biol. 39:1983;299-306.
16. Persinger M.A. Geopsychology and geopsychopathology: mental processes and disorders associated with geochemical and geophysical variables. Experientia. 43:1987;92-104.
17. Persinger M.A. Neuropsychologica principia brevita: an application to traumatic (acquired) brain injury. Psychol. Repts. 77:1995;707-724.
18. Persinger M.A., Bureau Y.R.J., Kostakos M., Peredery O., Falter H. Behaviours of rats with insidious, multifocal brain damage induced by seizures following single peripheral injections of lithium and pilocarpine. Physiol. Behav. 53:1993;849-866.
19. Persinger M.A., Bureau Y.R.J., Peredery O. Dissociation between conditioned taste aversion and radial maze learning following seizure-induced multifocal brain damage: quantitative tests of serial vs. parallel circuit models of memory. Physiol. Behav. 56:1994;225-235.
20. Persinger M.A., Makarec K. Complex partial epileptic-like signs as a continuum from normals to epileptics: normative data and clinical populations. J. Clin. Psychol. 49:1993;33-45.
21. Persinger M.A., Makarec K., Bradley J.C. Characteristics of limbic seizures evoked by peripheral injections of lithium and pilocarpine. Physiol. Behav. 44:1988;27-37.
22. Polman C.H., Dijkstra C.D., Sminia T., Koestsier J.C. Immunohistological analysis of macrophages in the central nervous system of Lewis rats with acute experimental allergic encephalomyelitis. J. Neuroimmunol. 11:1986;215-222.
23. Poser C.M. Trauma and multiple sclerosis: an hypothesis. J. Neurol. 234:1987;155-156.
24. Poser C.M. The differential diagnosis between multiple sclerosis and chronic fatigue postviral syndrome. Hyde B.M., Goldstein J., Levin P. The Nightingale Research Foundation review of the clinical and scientific basis of myalgic encephalomyelitis/chronic fatigue syndrome. 1992;387-394 The Nightingale Foundation, Toronto.
25. Roberts R.J., Gorman L.L., Lee G.P., Hines M.E., Richardson E.D., Riggle T.A., Varney N.R. The phenomenology of multiple partial seizure-like symptoms without stereotyped spells: an epilepsy spectrum disorder? Epilep. Res. 13:1992;167-177.
26. Sweeney J.E. Nonimpact brain injury: grounds for clinical study of the neuropsychological effects of acceleration forces. The Clin. Neuropsychol. 6:1992;443-457.