Ofloxacin levels after intravitreal injection. Effects of trauma and inflammation

Ophthalmic Research

Volumn 31, Issue 6, 1999, Pages 446-451

  Öztürk, Faruk ^a,c   Kortunay, Selim ^b   Kurt, Emin ^a   Inan, Ü Übeyt ^a   Ilker, S Sami ^a   Basci, Nursabah E ^b   Bozkurt, Atila ^b   Kayaalp, S Oǧuz ^b  

^a CELAL BAYAR UNIVERSITY   (Turkey)

^b HACETTEPE UNIVERSITY   (Turkey)

^c Merkez Efendi Mh Senol Sk Y   (Turkey)

Author keywords

Endophthalmitis; Intravitreal injection; Ofloxacin; Pharmacokinetics; Trauma

Indexed keywords

ANTIBIOTIC AGENT; OFLOXACIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIUM CONTAMINATION; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; DRUG TISSUE LEVEL; ENDOPHTHALMITIS; EYE INJURY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFLAMMATION; INTRAVITREAL DRUG ADMINISTRATION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; VITREOUS BODY;

ANIMALS; ANTI-INFECTIVE AGENTS; ENDOPHTHALMITIS; EYE INJURIES; HALF-LIFE; INJECTIONS; OFLOXACIN; OSMOLAR CONCENTRATION; RABBITS; STAPHYLOCOCCAL INFECTIONS; VITREOUS BODY; WOUNDS, PENETRATING;

EID: 0032885506     PISSN: 00303747     EISSN: None     Source Type: Journal    
DOI: 10.1159/000055570     Document Type: Article

References (20)

1. Todd PA, Faulds D: Ofloxacin: A reappraisal of its antimicrobial activity. pharmacology and therapeutic use. Drugs 1991;42:825-876.
2. Osato MS, Jensen HG, Trousdale MD, Bosso JA, Borrmann LR, Frank J, Akers P: The comparative in vitro activity of ofloxacin and selected ophthalmic agents against ocular bacterial isolates. Am J Ophthalmol 1989;108:380-386.
3. Nobe JR, Gomez DS, Liggett P, Smith RE, Robin JB: Post-traumatic and postoperative endophthalmitis: A comparison of visual outcomes. Br J Ophthalmol 1987;71: 614-616.
4. Verbraeken H, Rysselaraere M: Post-traumatic endophthalmitis. Eur J Ophthalmol 1994;4:1-5.
5. Duch-Samper AM, Menezo JL, Hurdato-Sarrio M: Endophthalmitis following penetrating eye injuries. Acta Ophthalmol Scand 1997;75: 104-106.
6. Alfaro DV, Roth D, Lignett PE: Posttraumatic endophthalmitis: Causative organisms, treatment, and prevention. Retina 1994;14: 206-211.
7. Barza M, Lynch E, Baum JL: Pharmacokinetics of newer cephalosporins after subconjunctival and intravitreal injection in rabbits. Arch Ophthalmol 1993;111:121-125.
8. Baum J, Peyman GA, Barza M: Intravitreal administration of antibiotic in the treatment of bacterial endophthalmitis. III. Consensus. Surv Ophthalmol 1982;26:204-206.
9. Roth DB, Flynn HW: Antibiotic selection in the treatment of endophthalmitis: The significance of drug combinations and synergy. Surv Ophthalmol 1997;41:395-401.
10. Mochizuki K, Toisaki M, Wakabayashi K: Effects of vancomycin and ofloxacin on rabbit ERG in vitro. Jpn J Ophthalmol 1991;35:435-445.
11. Pearson PA, Hainsworth DP, Ashton P: Clearance and distribution of ciprofloxacin after intravitreal injection. Retina 1993;13:326-330.
12. Mandell BA, Meredith TA, Aguilar E, El-Massry A, Sawant A, Gardner S: Effect of inflammation and surgery of amikacin levels in the vitreous cavity. Am J Ophthalmol 1993;115:770-774.
13. Shaarawy A, Meredith TA, Kincaid M, Dick J, Aguilar E, Ritchie DJ, Reichley RM: Intraocular injection of ceftazidime: Effects of inflammation and surgery. Retina 1995;15: 433-438.
14. Cobo LC, Forster RK: The clearance of intravitreal gentamicin. Am J Ophthalmol 1981;92:59-62.
15. Kane A, Barza M, Baum J: Intravitreal injection of gentamicin in rabbits: Effect of inflammation and pigmentation on half-life and ocular distribution. Invest Ophthalmol Vis Sci 1981;20:593-597.
16. Ficker L, Meredith TA, Gardner S, Wilson LA: Cefazolin levels after intravitreal injection: Effects of inflammation and surgery. Invest Ophthalmol Vis Sci 1990;31:502-505.
17. Aguilar HE, Meredith TA, El-Massry A, Shaarawy A, Kincaid M, Dick J, Ritchie DJ, Reichley RM, Neisman MK: Vancomycin levels after intravitreal injection: Effects of inflammation and surgery. Retina 1995;15:428-432.
18. Alfaro DV, Runyan T, Kirkman E, Tran VT, Lignett PE: Intravenous cefazolin in penetrating eye injuries: Treatment of posttraumatic endophthalmitis. Retina 1993;12:331-334.
19. Peyman GA, Pague JT, Meihels HI, Bennett TO: Postoperative endophthalmitis: A comparison of method for treatment and prophylaxis with gentamicin. Ophthalmic Surg 1975; 6:45-55.
20. Başci NE, Bozkurt A, Kalayci D, Kayaalp SO: Rapid liquid chromatographic assay of ciprofloxacin in human aqueous humor. J Pharm Biomed Anal 1996;14:353-356.