Characterization of epididymal sperm motion and its correlation with stages of target cells in rats given α-chlorohydrin, cyclophosphamide or nitrazepam

Journal of Toxicological Sciences

Volumn 24, Issue 3, 1999, Pages 187-197

  Kaneto, Masako ^a   Kanamori, Susumu ^a   Hara, Katsumi ^a   Kishi, Kurajiro ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

2 week study; CASA; Cyclophosphamide; Nitrazepam; Sperm motion; chlorohydrin

Indexed keywords

ALPHA CHLOROHYDRIN; CYCLOPHOSPHAMIDE; NITRAZEPAM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER STAGING; EPIDIDYMIS FAT; GERM CELL; HISTOPATHOLOGY; NONHUMAN; QUANTITATIVE DIAGNOSIS; RAT; SEMEN ANALYSIS; SPERMATID; TARGET CELL;

ANIMALIA;

EID: 0032885307     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.24.3_187     Document Type: Article

References (18)

1. Dunnett, C. W. (1955): A multiple comparison procedure for comparing several treatments with a control. J. Am. Statist. Assoc., 50, 1096-1121.
2. Gad, S. and Weil, C. S. (1982): Statistics for toxicologist. In principles and methods of toxicology (Wallance, H. A. ed.) pp. 273-320. Raven Press, New York.
3. Higuchi, H., Nakaoka, M., Katsuda, Y., Kawamura, S., Kato, T. and Matsuo, M. (1995): Collaborative assessment of optimal administration period and parameters to detect effects on male fertility in the rat: Effects of cyclophosphamide on the male reproductive system. J. Toxicol. Sci., 20, 239-249.
4. Hoyt, J. A., Fisher, L. F., Hoffman, W. P., Swisher, D. K. and Seyler, D. E. (1994): Utilization of a short-term male reproductive toxicity study design to examine effects of α-chlorohydrin (3-chloro-1,2-propanediol). Reprod. Toxicol., 8, 237-250.
5. Jones, A. R. (1983): Antifertility actions of α-chlorohydrin in the male. Aust. J. Biol. Sci., 36, 333-350.
6. Jones, A. R., Davies, P., Edwards, K. and Jackson, H. (1969): Antifertility effects and metabolism of α- and epi-chlorolrydrins in the rat. Nature, 224, 83.
7. Kar, R. N. and Das, R. K. (1983): Induction of sperm head abnormalities in mice by three tranquilizers. Cytobios, 36, 45-51.
8. Kishi, K., Kanamori, S., Maruyama, T., Sasaki, K., Hara, K., Kawai, M. and Ikeuchi, K. (1995): Potential parameters of male Reproductive toxicity: Reproductive performance, histopathology and sperm evaluation in SD rats given nitrazepam. J. Toxicol. Sci., 20, 329-339.
9. Lu, C. C. and Meistrich, M. L. (1979) : Cytotoxic effects of chemotherapeutic drugs on mouse testis cells. Cancer Res., 39, 3575-3582.
10. Matsui, H., Mitsumori, K., Yasuhara, K., Onodera, H., Shimo, T. and Takahashi, M. (1995): Morphological evaluation of cyclophosphamide testicular toxicity in rats using quantitative morphometry of spermatogenic cycle stages. J. Toxicol. Sci., 20, 407-414.
11. Perreault, S. D. (1997): The mature spermatozoon as a target for reproductive toxicants. In comprehensive toxicology (Sipes, I. G., McQueen, C. A. and Gandolfi, A. J. eds.), vol. 10, Reproductive and Endocrine Toxicology (Boekelheide, K., Chapin, R. E., Hoyer, P. B. and Harris, C. eds.), pp. 165-179, Elsevier Science Ltd., Oxford.
12. Sanbuissho, A., Terada, S., Suzuki, K., Masuda, N., Teranishi, M. and Masuda, H. (1995): Male reproductive toxicity study of nitrazepam in rats. J. Toxicol. Sci., 20, 319-328.
13. Toth, G. P., Wang, S. -R., McCarthy, H., Tocco, D. R. and Smith, M. K. (1992): Effects of three male reproductive toxicants on rat cauda epididymal sperm motion. Reprod. Toxicol., 6, 507-515.
14. Toth, G. P., Zenick, H. and Smith, M. K. (1989): Effects of epichlorohydrin on male and female reproduction in Long-Evans rats. Fund. Appl. Toxicol., 13, 16-25.
15. Trasler, J. M., Hales, B. F. and Robaire, B. (1985): Paternal cyclophosphamide treatment causes fetal loss and malformations without affecting male fertility. Nature, 316, 144-146.
16. Trasler, J. M., Hales, B. F. and Robaire, B. (1986): Chronic low dose cyclophosphamide treatment of adult male rats: Effect on fertility, pregnancy outcome and progeny. Biol. Reprod., 34, 275-283.
17. Woods, J. and Garside, D. A. (1996): An in vivo and in vitro investigation into the effects of α-chlorohydrin on sperm motility and correlation with fertility in the Han Wister rat. Reprod. Toxicol., 10, 199-207.
18. Yamada, T., Inoue, T., Sato, A., Yamagishi, K. and Sato, M. (1995): Effects of short-term administration of α-chlorohydrin on reproductive toxicity parameters in male Sprague-Dawley rats. J. Toxicol. Sci., 20, 195-206.