Insulin: New roles for an ancient hormone

European Journal of Clinical Investigation

Volumn 29, Issue 10, 1999, Pages 842-852

  Ferrannini, E ^a,b   Galvan, A Q ^a   Gastaldelli, A ^a   Camastra, S ^a   Sironi, A M ^a   Toschi, E ^a   Baldi, S ^a   Frascerra, S ^a   Monzani, F ^a   Antonelli, A ^a   Nannipieri, M ^a   Mari, A ^a   Seghieri, G ^a   Natali, A ^a  

^a CNR   (Italy)

^b INSTITUTE OF CLINICAL PHYSIOLOGY   (Italy)

Author keywords

Insulin; Insulin action; Insulin resistance

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CORTICOTROPIN RELEASING FACTOR; INSULIN; SODIUM; URIC ACID;

ARTICLE; BLOOD BRAIN BARRIER; CALCIUM TRANSPORT; CENTRAL NERVOUS SYSTEM; DIABETES MELLITUS; DYSLIPIDEMIA; FEEDBACK SYSTEM; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; HEART MUSCLE REFRACTORY PERIOD; HUMAN; HYPERINSULINEMIA; HYPERTENSION; HYPERURICEMIA; INSULIN BLOOD LEVEL; INSULIN DEFICIENCY; INSULIN RESISTANCE; INSULIN RESPONSE; LIPOLYSIS; MEMBRANE POLARIZATION AND DEPOLARIZATION; METABOLIC REGULATION; NONHUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; QT INTERVAL; STRESS; SYMPATHETIC NERVE; THERMOGENESIS; THROMBOCYTE AGGREGATION; URINARY EXCRETION; VAGUS REFLEX; VASODILATATION;

ANIMALS; CARDIOVASCULAR DISEASES; GLUCOSE; HUMANS; HYPERINSULINISM; INSULIN; INSULIN RESISTANCE; LIPOLYSIS; MODELS, BIOLOGICAL; PLATELET AGGREGATION;

EID: 0032885237     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.1999.00536.x     Document Type: Article

References (72)

1. 1 Roth J, Kahn CR, Lesniak MA et al. Receptors for insulin, NSILA-s and growth hormone: applications to disease states in man. Rec Progr Horm Res, 1975;31:95-110.
2. 2 Rabinowitz D, Zierler KL. Forearm metabolism in obesity and its response to intra-arterial insulin. Characterization of insulin resistance and evidence for adaptative hyperinsulinism. J Clin Invest, 1962;12:2173-81.
3. 3 Ferrannini E, Pilo A. Pattern of insulin delivery after intravenous glucose injection, and its relation to plasma glucose disappearance. J Clin Invest, 1979;64:243-9.
4. 4 Efendic S, Cerasi E, Luft R, Gladnikoff G. Potentiation of glucose-induced insulin release by glucose in the isolated pancreas of fed and fasted rats. Diabetes, 1976;25:949-57.
5. 5 Porte D Jr, Woods SC. Neural regulation of islet hormones and its role in energy balance and stress hyperglycemia. In: Rifkin H, Porte D Jr, editors. Diabetes Mellitus: Theory and Practice. New York: Elsevier; 1990. p.175-97.
6. 6 Ebert R, Creutzfeld W. Gastrointestinal peptides and insulin secretion. Diab Metab Rev, 1987;3:1-6.
7. 7 Jaspan JB, Lever E, Polonsky KS, Van Cauter E. In vivo pulsatility of pancreatic islet peptides. Am J Physiol, 1986;251: E215-E226.
8. 8 Flakoll P, Carlson MG, Cherrington AD. Physiologic action of insulin. In: LeRoith D, Taylor SI, Olefsky JM, editors. Diabetes Mellitus A Fundamental and Clinical Text. Philadelphia: Lippincott-Raven Publishers; 1996. p.121-32.
9. 9 Ferrannini E, Natali A, Bell P, Cavallo-Perin P, Lalic N, Mingrone G. Insulin resistance and hypersecretion in obesity. J Clin Invest, 1997;100:1166-73.
10. 10 Cheatam B, Kahn CR. Insulin action and the insulin signaling network. Endocrin Rev, 1995;16:117-42.
11. 11 DeFronzo RA. Pathogenesis of type 2 diabetes: metabolic and molecular implications for identifying diabetes genes. Diabetes Rev, 1997;5:177-269.
12. 12 Del Prato S, Leonetti F, Simonson DC, Sheehan P, Matsuda M, DeFronzo RA. Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin secretion and insulin sensitivity in man. Diabetologia, 1994;37: 1025-35.
13. 13 Ferrannini E. Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: problems and prospects. Endocr Rev, 1998;19:477-90.
14. 14 Kulkarni RN, Bruning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR. Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell, 1999;96: 329-39.
15. 15 Unger RH, Grundy S. Hyperglycaemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: implications for the management of diabetes. Diabetologia, 1985;28:119-25.
16. 16 Yki-Järvinen H, Helve H, Koivisto VA. Hyperglycemia decreases glucose uptake in type 1 diabetes. Diabetes, 1987;36:892-6.
17. 17 Rossetti L, Giaccari A, DeFronzo RA. Glucose toxicity. Diabetes Care, 1990;13:610-30.
18. 18 Quiñones Galvan A, Sironi AM, Baldi S et al. Evidence that acute insulin administration enhances LDL-cholesterol susceptibility to oxidation in healthy humans. Arteriosclerosis Thromb Vasc Biol, in press.
19. 19 Mazzone T, Foster D, Chait A. In vivo stimulation of low-density lipoprotein degradation by insulin. Diabetes, 1984;33:333-8.
20. 20 Ferrannini E, Camastra S, Coppack SW, Fliser D, Golay A, Mitrakou A. Insulin action and non-esterified fatty acids. Proc Nutr Soc, 1997;56:753-61.
21. 21 Taskinen MR, Nestel PJ. Hypolipidemic agents: their role in diabetes mellitus. In: Alberti KGMM, Zimmet P, DeFronzo RA, editors. International Textbook of Diabetes Mellitus. 2nd ed. Chichester: John Wiley & Sons; 1997. p.883-98.
22. 22 Juhan-Vague I, Alessi MC, Vague P. Thrombogenic and fibrinolytic factors and cardiovascular risk in non-insulin-dependent diabetes mellitus. Ann Med, 1996;28:371-80.
23. 23 Calles-Escandon J, Mirza SA, Sobel BE, Schneider DJ. Induction of hyperinsulinemia combined with hyperglycemia and hypertriglyceridemia increases plasminogen activator inhibitor 1 in blood of normal human subjects. Diabetes, 1998;47:290-3.
24. 2-generating system that is activated by insulin via a mechanism bypassing the receptor kinase. J Clin Invest, 1992;89:1006-13.
25. 25 Quiñones-Galvan A, Muscelli E, Catalano C et al. Insulin decreases circulating vitamin E levels in humans. Metabolism, 1996;45:998-1003.
26. 26 Witzum JL. The oxidation hypothesis of atherosclerosis. Lancet, 1994;344:793-5.
27. 27 Camastra S, Bonora E, Del Prato S, Rett K, Weck M, Ferrannini E. Effect of obesity and insulin resistance on resting and glucose-induced thermogenesis. Int J Obes, in press.
28. 28 DeFronzo RA, Felig P, Ferrannini E, Wahren J. Effect of graded doses of insulin on splanchnic and peripheral potassium metabolism in man. Am J Physiol, 1980;238:E421-E427.
29. 29 Andres R, Baltzan M, Cader G, Zierler K. Effects of insulin on carbohydrate metabolism and on potassium in the forearm of man. J Clin Invest, 1962;41:108-15.
30. 30 DeFronzo RA, Cooke CR, Andres R, Faloona GR, Davis PJ. The effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man. J Clin Invest, 1975;55: 845-55.
31. 31 Trovati M, Massucco P, Anfossi G et al. Insulin influences the renin-angiotensin-aldosterone system in humans. Metabolism, 1989;38:501-3.
32. 32 Ferrannini E, Seghieri G, Muscelli E. Insulin and the renin-angiotensin-aldosterone system: influence of ACE inhibition. J Cardiovasc Pharmacol, 1994;24 (Suppl. 3):S61-S80.
33. 33 Rowe JW, Tobin JD, Rosa RM, Andres R. Effect of experimental potassium deficiency on glucose and insulin metabolism. Metabolism, 1980;29:498-502.
34. 34 Natali A, Quiñones Galvan A, Santoro D, Taddei S, Salvetti A, Ferrannini E. Relationship between insulin release, antinatriuresis, and hypokalemia following glucose ingestion in normal and hypertensive man. Cli Sci, 1993;85:327-35.
35. 35 Helderman JH, Elahi D, Andersen DK et al. Prevention of the glucose intolerance of thiazide diuretics by maintenance of body potassium. Diabetes, 1983;32:106-11.
36. 36 Skott P, Hother-Nielsen O, Bruun NE et al. Effects of insulin on kidney function and sodium excretion in healthy subjects. Diabetologia, 1989;32:694-9.
37. 37 Anderson EA, Hoffman RP, Balon TW, Sinkley CA, Mark AL. Hyperinsulinemia produces both sympathetic neuronal activation and vasodilation in normal humans. J Clin Invest, 1991;87:2246-52.
38. 38 Rocchini AP, Katch V, Kveselis D et al. Insulin and renal sodium retention in obese adolescents. Hypertension, 1989;14:367-74.
39. 39 Muscelli E, Natali A, Bianchi S et al. Effect of insulin on renal sodium and uric acid handling in patients with essential hypertension. Am J Hypertens, 1996;9:746-52.
40. 40 Quiñones Galvan A, Natali A, Baldi S et al. Effect of insulin on uric acid excretion in humans. Am J Physiol, 1995;268:E1-E8.
41. 41 Vuorinen-Markkola H, Yki-Järvinen H. Hyperuricemia and insulin resistance. J Clin Endocrinol Metab, 1994;78:25-9.
42. 42 Zierler K. Effect of insulin on membrane potential and potassium content of rat muscle. Am J Physiol, 1959;197:515-23.
43. +. Diabetes, 1989;38:333-7.
44. 44 Zierler K, Wu FS. Insulin acts on Na, K, and Ca currents. Trans Assoc Am Physicians, 1988;101:320-5.
45. + pump. Am J Physiol, 1984;247: H833-H839.
46. 46 Muscelli E, Emdin M, Natali A et al. Cardiac effects of insulin in humans: influence of obesity. J Clin Endocrinol Metab, 1998;83:2084-90.
47. 47 Laakso M, Edelman SV, Brechtel G, Baron AD. Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man: a novel mechanism for insulin resistance. J Clin Invest, 1990;85:1844-52.
48. 48 Baron AD, Laakso M, Brechtel G, Edelman SV. Mechanism of insulin resistance in insulin-dependent diabetes mellitus: a major role for reduced skeletal muscle blood flow. J Clin Endocrinol Metab, 1991;73:637-43.
49. 49 Laakso M, Edelman S, Brechtel G, Baron AD. Impaired insulin mediated skeletal muscle blood flow in patients with NIDDM. Diabetes, 1992;41:1076-83.
50. 50 Baron AD. Cardiovascular actions of insulin in humans. Implications for Insulin Sensitivity and Vascular Tone. In: Insulin Resistance and Disease. Ferrannini E, editor. Baillière's Clinical Endocrinology and Metabolism. London: LBaillière Tindall; Vol 7 (4); 1993. p.961-88.
51. 51 Yki-Järvinen H, Utriainen T. Insulin-induced vasodilatation: physiology or pharmacology? Diabetologia, 1998;41:369-79.
52. 52 Capaldo B, Gastaldelli A, Antoniello S et al. Splanchnic and leg substrate exchange after ingestion of a natural mixed mean in humans. Diabetes, 1999;48:958-66.
53. + exchange by insulin in the human forearm. Am J Physiol, 1988;255: E953-E958.
54. 54 Natali A, Bonadonna R, Santoro D et al. Insulin resistance and vasodilatation in essential hypertension. Studies with adenosine. J Clin Invest, 1994;94:1570-6.
55. 55 Natali A, Quiñones Galvan A, Toschi E, Pecori N, Sanna G, Ferrannini E. Vasodilation with sodium nitroprusside does not improve insulin action in essential hypertension. Hypertension, 1998;31:632-6.
56. 56 Randin D, Vollenweider P, Tappy L, Jequier E, Nicod P, Scherrer U. Effects of adrenergic and cholinergic blockade on insulin-induced stimulation of calf blood flow in humans. Am J Physiol, 1994;266:R809-R816.
57. 57 Scherrer U, Randin D, Vollender P, Vollender L, Nicod P. Nitric oxide release accounts for insulin's vascular effects in humans. J Clin Invest, 1994;94:2511-5.
58. 58 Steinberg HO, Brechtel G, Johson A, Fireberg N, Baron AD. Insulin-mediated skeletal muscle vasodilatation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. J Clin Invest, 1994;94:1172-9.
59. 59 Tack CJJ, Lutterman JA, Vervoot G, Thien T, Smits P. Activation of the sodium-potassium pump contributes to insulin-induced vasodilatation in humans. Hypertension, 1996;28:426-32.
60. 60 Taddei S, Virdis A, Mattei P, Natali A, Ferrannini E, Salvetti A. Effect of insulin on acetylcholine-induced vasodilatation in normotensive subjects and patients with essential hypertension. Circulation, 1995;92:2911-8.
61. 61 Meharg JV, McGowan-Jordan J, Charles A, Parmelee JT, Cutaia MV, Rounds S. Hydrogen peroxide stimulates sodium-potassium pump activity in cultured pulmonary arterial endothelial cells. Am J Physiol, 1993;265:L613-L621.
62. +-ATPase gene expression by insulin in vascular smooth muscle cells. Am J Hypertens, 1993;6:626-9.
63. 63 Kahn AM, Seidel CL, Allen JC, O'Neil G, Shelat H, Song T. Insulin reduces contraction and intracellular calcium concentration in vascular smooth muscle. Hypertension, 1993;22:735-42.
64. 64 Trovati M, Anfossi G. Insulin, insulin resistance and platelet function: similarities with insulin effects on cultured vascular smooth muscle cells. Diabetologia, 1998;41:609-22.
65. +-ATPase activity by nitric oxide: a cGMP-independent effect. Am J Physiol, 1994;266:H2146-51.
66. 66 Moncada S, Palmer RMJ. The L-Arginine-Nitric Oxide Pathway in the Vessel Wall. In: Moncada S, Higgs B., editors. Nitric Oxide from L-Arginine: a Bioregulatory System. Amsterdam: Elesevier; 1990. p.19-33.
67. 67 Baldi S, Natali A, Buzzigoli G, Quiñones Galvan A, Sironi AM, Ferrannini E. In vivo effect of insulin on intracellular calcium concentrations: relation to insulin resistance. Metabolism, 1996;45:1402-7.
68. 68 Catalano C, Muscelli E, Quiñones Galvan A et al. Effect of insulin on systemic and renal handling of albumin in nondiabetic and NIDDM subjects. Diabetes, 1997;46: 868-75.
69. 69 Rowe JR, Young JB, Minaker KL, Stevens AL, Pallotta J, Landsberg L. Effect of insulin and glucose infusions on sympathetic nervous system activity in normal man. Diabetes, 1981;30:219-25.
70. 70 Gans RO. v d Toorn L, Bilo HJ, Nauta JJ, Heine RJ, Donker AJ. Renal and cardiovascular effects of exogenous insulin in healthy volunteers. Cli Sci, 1991;80:219-25.
71. 71 Schwartz MW, Figlewicz DP, Baskin DB, Woods SC, Porte D Jr Insulin in the brain: a hormonal regulator of energy balance. Endocr Rev, 1992;13:81-113.
72. 72 Davis SN, Colburn C, Robbins R et al. Evidence that the brain of the conscious dog is insulin sensitive. J Clin Invest, 1995;95:593-602.