Influence of the organization of binary mixes on their compactibility

Pharmaceutical Research

Volumn 16, Issue 9, 1999, Pages 1449-1455

  Barra, J ^a,b   Falson Rieg, F ^c   Doelker, E ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b UPSA Laboratories   (France)

^c UNIVERSITÉ LYON 1   (France)

Author keywords

Binary mixes; Compactibility; Particle size; Powder; Surface energy; Tensile strength

Indexed keywords

EXCIPIENT; IBUPROFEN; METHYLCELLULOSE; NIFLUMIC ACID;

ARTICLE; CHEMICAL COMPOSITION; DRUG COATING; PARTICLE SIZE; PHARMACEUTICAL ENGINEERING; PRIORITY JOURNAL; SURFACE PROPERTY; TABLET COMPRESSION; TENSILE STRENGTH;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTICHOLESTEREMIC AGENTS; CELLULOSE; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; METHYLCELLULOSE; MICROSCOPY, ELECTRON, SCANNING; NIFLUMIC ACID; PARTICLE SIZE; POWDERS; SURFACE PROPERTIES; TABLETS; TENSILE STRENGTH;

EID: 0032884861     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018967529128     Document Type: Article

References (16)

1. H. Leuenberger. The compressibility and compactibility of powder systems. Int. J. Pharm. 12:41-55 (1982).
2. J. Barra, F. Lescure, F. Falson-Rieg, and E. Doelker. Can the organisation of a binary mix be predicted from the surface energy, cohesion parameter and particle size of its components? Pharm. Res. 15:1727-1736 (1998).
3. S. M. Upadrashta, P. R. Katikaneni, G. A. Hileman, S. H. Neau, and C. E. Rowlings. Compressibility and compactibility properties of ethylcellulose. Int. J. Pharm. 112:173-179 (1994).
4. J. T. Fell and J. M. Newton. The prediction of the tensile strength of tablets. J. Pharm. Pharmacol. 22:247-248 (1970).
5. H. Leuenberger and W. Jetzer. The compactibility of powder systems-A novel approach. Powder Technol. 37:209-218 (1984).
6. L. E. Holman and H. Leuenberger. The effect of varying the composition of binary powder mixtures and compacts on their properties. A percolation phenomenon. Powder Technol. 60:249-258 (1990).
7. S. TakTak-Jama Contribution à l'étude du comportement en compression de poudres et de leurs mélanges: optimisation de leur aptitude à la compression. Ph.D. thesis, University of Lille 1997, pp. 1-231.
8. H. Leuenberger. Compression of binary powder mixtures and solubility parameters of solids. Int. J. Pharm. 27:127-138 (1985).
9. G. D. Cook and M. P. Summers. The tensile strength of aspirin-Emcompress tablets. J. Pharm. Pharmacol. 37:29P (1985).
10. J. M. Newton, D. T. Cook, and C. E. Hollebon. The strength of tablets of mixed components. J. Pharm. Pharmacol. 29:247-249 (1977).
11. S. Majuru and D. E. Wurster. The effect of composition on the tabletting indices of binary powder mixtures. Pharm. Dev. Technol., 2:313-321 (1998).
12. K. A. Riepma, C. F. Lerk, A. H. De Boer, G. K. Bolhuis, and K. D. Kussendrager. Consolidation and compaction of powder mixtures: I. Binary mixtures of same particle size fractions of different types of crystalline lactose. Int. J. Pharm. 66:47-52 (1990).
13. G. Alderborn and C. Nyström. Studies on direct compression of tablets. IV. The effect of particle size on the mechanical strength of tablets. Acta Pharm. Suec. 19:381-390 (1982).
14. K. A. Riepma, J. Veenstra, A. H. De Boer, C. F. Lerk, and H. Vromans. Consolidation and compaction of powder mixtures: II. Binary mixtures of different particle size fractions of alpha-lactose monohydrate. Int. J. Pharm. 76:9-15 (1991).
15. D. Blattner, M. Kolb, and H. Leuenberger. Percolation theory and compactibility of binary powder systems. Pharm. Res. 7:113-117 (1990).
16. N. A. Armstrong and T. M. Cham. Changes in the particle size and size distribution during compaction of two pharmaceutical powders with dissimilar consolidation mechanisms. Drug Dev. Ind. Pharm. 12:2043-2059 (1986).