GABA agonists differentially modify blood glucose levels of diabetic rats

Japanese Journal of Pharmacology

Volumn 80, Issue 4, 1999, Pages 327-331

  Gomez, Rosane ^a   Asnis, Nelson ^a   Tannhauser, Seminamis L ^a   Barros, Helena M T ^a  

^a Fund Faculdade Fed Cie Medicas P   (Brazil)

Author keywords

GABA(A); GABA(B); Hyperglycemia; Insulin

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; AMINOOXYACETIC ACID; BACLOFEN; BENZODIAZEPINE; DIAZEPAM; GABOXADOL; GLUCOSE; INSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; FEMALE; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET; RAT; STREPTOZOCIN DIABETES;

EID: 0032882751     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.80.327     Document Type: Article

References (23)

1. Okada Y, Taniguchi H and Sigeaki B: High concentration of GABA in the pancreatic islets with special emphasis on B cell. In Problems in GABA Research From Brain to Bacteria, Edited by Okada Y and Roberts E, pp 379-386, Excerpta Medica, Amsterdam (1982)
2. Okada Y: Localization and function of GABA in the pancreatic islets. In GABAergic Mechanisms in the Mammalian Periphery, Edited by Erdö SL and Bowery NG, pp 223 -240, Raven Press, New York (1986)
3. Reetz A, Solimena M, Matteoli M, Folli F, Takei K and Camili P: GABA and pancreatic β-cell: colocalization of glutamic acid decarboxylase (GAD) and GABA with synaptic-like microvesicles suggests their role in GABA storage and secretion. EMBO J 10, 1275-1284 (1991)
4. Vincent SR, Hökfelt T, Wu J, Elde RP, Morgan LM and Kimmel JR: Immunohistochemical studies of the GABA system in the pancreas. Neuroendocrinology 36, 197-204 (1983)
5. Garry DJ, Coulter HD, McIntee TJ, Wu J and Sorenson RL: Immunoreactive GABA transaminase within the pancreatic islet is localized in mitochondria of the B-cell. J Histochem Cytochem 35, 831-836 (1987)
6. Vincent SR and Brown JC: Autoradiographic studies of the γ-aminobutyric acid (GABA) system in the rat pancreas. Histochemistry 88, 171-173 (1988)
7. Gilon P and Remade C: High-affinity GABA uptake in a sub-population of somatostatin cells in rat pancreas. J Histochem Cytochem 37, 1133-1139 (1989)
8. Reusens-Billen B, Pirlot X, Remade C, Hoet JJ and Gasparo M: Localization of GABA high-affinity binding sites in the pancreas of neonatal rat. Tissue Res 235, 503-508 (1984)
9. A mRNAs have functional receptors. J Neurosci 14, 5429-5436 (1994)
10. Marchetti P, Trincavelli L and Giannarelli R: A Characterization of peripheral benzodiazepine receptors in purified large mammal pancreatic islet. Biochem Pharmacol 51, 1437-1442 (1996)
11. A receptor subtype mRNA in human pancreatic tissue. FEBS Lett 346, 257-262 (1994)
12. Atkinson MA and Maclaren NK: Islet cells autoantigens in insulin-dependent diabetes. J Clin Invest 92, 1608-1616 (1993)
13. Junod A: Diabetogenic action of streptozotocin: relationship of dose to metabolic response. J Clin Invest 48, 2129-2139 (1969)
14. Barros HMT, Tannhauser SL, Tannhauser MAL and Tannhauser M: The effect of GABAergic drugs on grooming behavior in the open field. Pharmacol Toxicol 74, 339-349 (1994)
15. A receptor in the rat pancreas. Mol Cell Endocrinol 103, 157-163 (1994)
16. Kawai K and Unger RH: Effects of γ-aminobutyric acid on insulin, glucagon, and somatostain release from isolated perfused dog pancreas. Endocrinology 113, 111-113 (1983)
17. Sorenson R, Garry D and Brelje C: Structural and functional considerations of GABA in islets of Langerhans. Diabetes 40, 1365-1367 (1991)
18. Cavagnini F, Pinto M, Dubini A, Invitti C, Cappelletti G and Polli E: Effects of gamma aminobutyric acid (GABA) and muscimol on endocrine pancreatic function in man. Metabolism 31, 73-77 (1982)
19. Passariello N, Giugliano D, Torella R, Sgambato S, Coppola L and Frascolla N: A possible role for γ-aminobutyric acid in the control of the endocrine pancreas. J Clin Endocrinol Metab 54, 1145-1149 (1982)
20. Gerber JC and Hare TA: GABA in peripheral tissues: presence and actions in endocrine pancreatic function. Brain Res Bull 5, Suppl 2, 341-346 (1980)
21. A-receptor chloride channels. Nature 341, 233-236 (1989)
22. Robbins MS, Grouse LH, Sorenson RL and Elde RP: Effect of muscimol on glucose-stimulated somatostatin and insulin release from the isolated, perfused rat pancreas. Diabetes 30, 168-171 (1981)
23. Tillakaratne NJK, Medina-Kauwe L and Gibson KM: Gamma-aminobutyric acid (GABA) metabolism in mammalian neural and nonneural tissues. Comp Biochem Physiol 2, 247-263 (1995)