Noninvasive tracing of human liver metabolism: Comparison of phenylacetate and apoB-100 to sample glutamine

American Journal of Physiology - Endocrinology and Metabolism

Volumn 277, Issue 3 40-3, 1999, Pages

  Diraison, Frédérique ^a   Large, Valérie ^a   Maugeais, Cyrille ^b   Krempf, Michel ^b   Beylot, Michel ^a  

^a UNIVERSITÉ LYON 1   (France)

^b Institut Régional du Cancer Nantes Atlantique   (France)

Author keywords

Chemical biopsy; Diabetes; Gluconeogenesis; Mass spectrometry; Stable isotope

Indexed keywords

ALANINE; APOLIPOPROTEIN B100; GLUTAMINE; OXALOACETIC ACID; PHENYLACETIC ACID; PYRUVIC ACID; VERY LOW DENSITY LIPOPROTEIN;

ADULT; ARTICLE; CHEMICAL LABELING; CONTROLLED STUDY; FEMALE; GLUCONEOGENESIS; HUMAN; HUMAN EXPERIMENT; ISOTOPE DILUTION ASSAY; LIVER METABOLISM; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NORMAL HUMAN; PERIPHERAL CIRCULATION; PRIORITY JOURNAL;

EID: 0032881896     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1999.277.3.e529     Document Type: Article

References (40)

1. 13C labeling pattern of glutamate by gas chromatography-mass spectrometry. Anal. Biochem. 212: 532-536, 1993.
2. 13C urea enrichment by gas chromatography-mass spectrometry and gas chromatography isotope ratio mass spectrometry. Biol. Mass Spectrom. 23: 510-513, 1994.
3. 13C labeling pattern of glucose by gas chromatography-mass spectrometry. Anal. Biochem. 212: 526-531, 1993.
4. Beylot, M., F. Riou, F. Bienvenu, and R. Mornex. Increased ketonaemia in hyperthyroidism; evidence for a β-adrenergic mechanism. Diabetologia 19: 505-510, 1980.
5. Beylot, M., M. Soloviev, F. David, B. Landau, and H. Brunengraber. Tracing hepatic gluconeogenesis relative to citric acid cycle activity in vitro and in vivo. J. Biol. Chem. 270: 1509-1514, 1995.
6. Chandramouli, V., K. Ekberg, W. Schumann, S. C. Kaihan, J. Wahren, and B. R. Landau. Quantifying gluconeogenesis during fasting. Am. J. Physiol. 273 (Endocrinol. Metab. 36): E1209-E1215, 1997.
7. Cohn, J., D. Wagner, S. Cohn, J. Millar, and E. Schaefer. Measurement of very low density and low density lipoprotein apolipoprotein (Apo) B-100 and high density lipoprotein Apo A-I production in human subjects using deuterated leucine. J. Clin. Invest. 85: 804-811, 1990.
8. Consoli, A., N. Nurjhan, F. Capani, and J. E. Gerich. Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM. Diabetes 38: 550-557, 1989.
9. Diraison, F., V. Large, H. Brunengraber, and M. Beylot. Non-invasive tracing of liver intermediary metabolism in normal subjects and in moderately hyperglycaemic NIDDM subjects. Evidence against increased gluconeogenesis and hepatic fatty acid oxidation in NIDDM. Diabetologia 41: 212-220, 1998.
10. Frénais, R., K. Ouguerram, C. Maugeais, P. Mahot, P. Maugre, M. Krempf, and T. Magot. High density lipoprotein apolipoprotein AI kinetics in NIDDM: a stable isotope study. Diabetologia 40: 578-583, 1997.
11. Gay, L. J., P. Scheiter, Y. Schutz, V. Di Vetta, E. Jequier, and L. Tappy. A non-invasive assessment of hepatic glycogen kinetics and post-absorptive gluconeogenesis in man. Diabetologia 37: 517-523, 1994.
12. Guilly, R. E., E. Billion-Rey, C. Pachiaudi, S. Normand, J. P. Riou, E. S. Jumeau, and J. L. Brazier. On-line purification and carbon 13 isotopic analysis of carbon dioxide in breath: evaluation of on-line gas chromatography isotope ratio mass spectrometry. Anal. Chim. Acta 259: 193-202, 1992.
13. Hales, C. M., and P. J. Randle. Immunoassay of insulin with insulin antibody precipitate. Biochem. J. 56: 136-142, 1963.
14. Harris, V., G. Faloona, and R. H. Unger. Glucagon. In: Methods of Radioimmunoassay, edited by B. M. Jaffe and H. R. Behrman. New York: Academic, 1979, p. 643-671.
15. 12C in the pathway of gluconeogenesis in vivo. Federation Proc. 41: 104-109, 1985.
16. Jahoor, F., D. G. Burrin, P. J. Reeds, and M. Frazer. Measurement of plasma protein synthesis rate in infant pig: an investigation of alternative tracer approaches. Am. J. Physiol. 267 (Regulatory Integrative Comp. Physiol. 36): R221-R227, 1994.
17. James, M. O., R. L. Smith, R. T. Williams, and M. Reidenberg. The conjugation of phenylacetic acid in man, sub-human primates and some non-primate species. Proc. R. Soc. Lond. 182: 25-35, 1957.
18. Krebs, H., R. Hems, M. Weidemann, and R. Speake. The fate of isotopic carbon in kidney cortex synthesizing glucose from lactate. Biochem. J. 101: 242-249, 1966.
19. Landau, B., V. Chandramouli, W. C. Schumann, K. Ekberg, K. Kumaran, S. C. Kalhan, and J. Wahren. Estimates of Krebs cycle activity and contributions of gluconeogenesis to hepatic glucose production in fasting healthy subjects and IDDM patients. Diabetologia 38: 831-838, 1995.
20. Landau, B., J. Wahren, V. Chandramouli, W. Schumann, K. Ekberg, and S. Kalhan. Contributions of gluconeogenesis to glucose production in the fasted state. J. Clin. Invest. 98: 378-385, 1996.
21. 2O for estimating rates of gluconeogenesis. Applications to the fasted state. J. Clin. Invest. 95: 172-178, 1995.
22. Large, V., H. Brunengraber, M. Odeon, and M. Beylot. Use of the labeling pattern of liver glutamate to calculate rates of citric acid cycle and gluconeogenesis. Am. J. Physiol. 272 (Endocrinol. Metab. 35): E51-E58, 1997.
23. Large, V., M. Soloviev, H. Brunengraber, and M. Beylot. Lactate and pyruvate isotopic enrichments in plasma and liver of post-absorptive and starved rats. Am. J. Physiol. 268 (Endocrinol. Metab. 31): E880-E888, 1995.
24. Lichtenstein, A. H., J. S. Cohn, D. L. Hachey, J. S. Millar, J. M. Ordovas, and E. J. Schaefer. Comparison of deuterated leucine, valine and lysine in the measurement of human apolipoprotein A-I and B-100 kinetics. J. Lipid Res. 31: 1693-1701, 1990.
25. Magnusson, I., W. Schumann, V. Bartsch, V. Chandramouli, K. Kumaran, J. Wahren, and B. Landau. Non-invasive tracing of Krebs cycle metabolism in liver. J. Biol. Chem. 266: 6975-6984, 1991.
26. Patterson, B. W., and R. R. Wolfe. Concentration dependence of methyl palmitate isotope ratios by electron impact ionization gas chromatography/mass spectrometry. Biol. Mass Spectrom. 22: 481-486, 1993.
27. Periello, G., S. Pampanelli, P. Del Sindaco, C. Lalli, M. Ciofetta, E. Volpi, F. Santeusanio, P. Brunetti, and G. B. Bolli. Evidence of systemic glucose production and gluconeogenesis in an early stage of NIDDM. Diabetes 46: 1010-1016, 1997.
28. 13C]glycerol and mass isotopomer distribution analysis of glucose. Am. J. Physiol. 269 (Endocrinol. Metab. 32): E516-E523, 1995.
29. 13C]glycerol: role of the infusion-sampling mode. Metabolism 45: 897-901, 1996.
30. Petersen, K., T. Price, G. Cline, D. Rothman, and G. Shulman. Contribution of net hepatic glycogenolysis to glucose production during the early postprandial period. Am. J. Physiol. 270 (Endocrinol. Metab. 33): E186-E191, 1996.
31. Schwenck, W. K., P. Berg, B. Beaufrere, J. Miles, and M. M. W. Haymond. Use of t-butyldimethylsilylation in the GCMS analysis of physiological compounds found in plasma using electron impact ionization. Anal. Biochem. 141: 101-109, 1984.
32. Strisower, E., G. Kolher, and I. Chaikoff. Incorporation of acetate carbon into glucose by liver slices from normal and alloxan diabetic rats. J. Biol. Chem. 188: 115-126, 1952.
33. 13C] glucose study. Am. J. Physiol. 270 (Endocrinol. Metab. 33): E709-E717, 1996.
34. 13C labelled glucose at a very low level of enrichment in man. Diabetologia 33: 449-456, 1990.
35. Watts, G. F., R. P. Naoumova, J. M. Kelly, F. M. Riches, K. D. Croft, and G. R. Thompson. Inhibition of cholesterogenesis decrease hepatic secretion of apo-B100 in normolipidemic subjects. Am. J. Physiol. 273 (Endocrinol. Metab. 36): E462-E470, 1997.
36. Webster, L., U. Siddiqui, S. Lucas, J. Strong, and J. Mieyal. Identification of separate acyl-CoA: glycine and acyl-CoA: L-glutamine N-acyltransferase activities in mitochondrial fractions from liver of rhesus monkey and man. J. Biol. Chem. 251: 3352-3358, 1976.
37. 13C]glucose and mass isotopomer analysis of apoB-100 ammo-acids in pigs. Am. J. Physiol. 274 (Endocrinol. Metab. 37): E365-E376, 1998.
38. Yang, D., M. Beylot, K. C. Agarwal, M. V. Soloviev, and H. Brunengraber. Assay of the human liver citric acid cycle probe phenylacetylglutamine and phenylacetate in plasma by gas chromatography-mass spectrometry. Anal. Biochem. 212: 277-282, 1993.
39. Yang, D., S. F. Previs, C. A. Fernandez, S. Dugelay, M. V. Soloviev, J. W. Hazey, K. C. Agarwal, W. C. Levine, F. David, P. Rinaldo, M. Beylot, and H. Brunengraber. Noninvasive probing of citric acid cycle intermediates in primate liver with phenylacetylglutamine. Am. J. Physiol. 270 (Endocrinol. Metab. 33): E882-E889, 1996.
40. Yki-Jarvinen, H., E. Helve, T. Sane, N. Nurjhan, and M. R. Taskinen. Insulin inhibition of overnight glucose production and gluconeogenesis from lactate. Am. J. Physiol. 256 (Endocrinol. Metab. 19): E732-E739, 1989.