Correlations between in vitro affinity of antipsychotics to various central neurotransmitter receptors and clinical incidence of their adverse drug reactions

European Journal of Clinical Pharmacology

Volumn 55, Issue 8, 1999, Pages 583-587

  Sekine, Y ^a   Rikihisa, T ^b   Ogata, H ^b   Echizen, H ^b   Arakawa, Y ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b MEIJI PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Adverse drug reactions; Antipsychotic drug; Receptor affinity

Indexed keywords

8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; ALPHA 1 ADRENERGIC RECEPTOR; BROMPERIDOL; CARPIPRAMINE; CHLORPROMAZINE; CLOCAPRAMINE; CLOSPIPRAMINE; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; EMONAPRIDE; HALOPERIDOL; HISTAMINE H1 RECEPTOR; KETANSERIN; LEVOMEPROMAZINE; MEPYRAMINE; MUSCARINIC RECEPTOR; NEUROLEPTIC AGENT; NEUROTRANSMITTER RECEPTOR; OXYPERTINE; PERICIAZINE; PIMOZIDE; PRAZOSIN; QUINUCLIDINYL BENZILATE; RISPERIDONE; SEROTONIN 2 RECEPTOR; SPIPERONE; SULPIRIDE; SULTOPRIDE; THIORIDAZINE; TIMIPERONE; ZOTEPINE;

ADVERSE DRUG REACTION; AKATHISIA; ANIMAL TISSUE; ARTICLE; BRAIN SYNAPTOSOME; DROWSINESS; DRUG RECEPTOR BINDING; DYSKINESIA; HUMAN; HYPOTENSION; IN VITRO STUDY; IN VIVO STUDY; INCIDENCE; JAPAN; MAJOR CLINICAL STUDY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RIGIDITY; SIDE EFFECT; TREMOR; XEROSTOMIA;

ADVERSE DRUG REACTION REPORTING SYSTEMS; AKATHISIA, DRUG-INDUCED; ANIMALS; ANTIPSYCHOTIC AGENTS; DYSKINESIA, DRUG-INDUCED; HUMANS; HYPOTENSION; INCIDENCE; KINETICS; MUSCLE RIGIDITY; RATS; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2; RECEPTORS, NEUROTRANSMITTER; SLEEP STAGES; TREMOR; XEROSTOMIA;

EID: 0032880890     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002280050676     Document Type: Article

References (17)

1. Seeman P, Lee T, Chau-Wong M, Wong K (1976) Antipsychotic drug doses and neuroleptic/dopamine receptors. Nature 261: 717-719
2. Bacopoulos NC, Spokes EG, Bird ED, Roth RH (1979) Antipsychotic drug action in schizophrenic patients: effect on cortical dopamine metabolism after long-term treatment. Science 205: 1405-1407
3. Creese I, Burt DR, Snyder SH (1976) Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs. Science 192: 481-483
4. Product information booklets used for the analysis were as follows: chlorpromazine (Contomin) (1995) Yoshitomi Pharmaceutical Industries, Ltd., Osaka, p 22; levomepromazine (Hirnamin) (1997), Shionogi Co. Ltd, Osaka, p 19; thioridazine (Melleril) (1997) Novartis Pharma K.K., Tokyo, pp 10-11; propericiazine (Neuleptil) (1997) Shionogi Co. Ltd., Osaka, p 24; haloperidol (Serenace) (1995) Dainippon Pharmaceutical Co. Ltd., Osaka, p 14; carpipramine (Defekton) (1995) Yoshitomi Pharmaceutical Industries, Ltd., Osaka, p 15; mosapramine (Cremin) (1991) Yoshitomi Pharmaceutical Industries, Ltd., Osaka, p 17; oxypertine (Folit) (1993) Daiichi Pharmaceutical Co. Ltd., Tokyo, pp 13-14; nemonapride (Emilace) (1994) Yamanouchi Pharmaceutical Co. Ltd., Tokyo, p 12; risperidone (Risperdal) (1996) Janssen-Kyowa Co., Tokyo, pp 11-12
5. Anonymous (1977) Summary of adverse drug reactions for clocapramine (Clofekton), Pharmaceuticals and Medical Devices Safety Information no. 27 pp 6-7, (1980) Summary of adverse drug reactions for pimozide (Orap), ibid no. 42 pp 76-80, (1983) Summary of adverse drug reactions for sulpiride (Dogmatyl), ibid no. 61 pp 26-34, (1989) Summary of adverse drug reactions for zotepine (Lodopin), ibid no. 95 pp 175-179, (1991) Summary of adverse drug reactions for timiperone (Tolopelon), ibid no. 108 pp 20-22, (1995) Summary of adverse drug reactions for bromperidol (Impromen), ibid suppl. pp 14-16 and (1997) Summary of adverse drug reactions for sultopride (Barnetil), ibid suppl. pp 9-11, Tokyo, Pharmaceutical and Medical Safety Bureau, Ministry of Health and Welfare, Japan
6. Anonymous (1977) Summary of adverse drug reactions for clocapramine (Clofekton), Pharmaceuticals and Medical Devices Safety Information no. 27 pp 6-7, (1980) Summary of adverse drug reactions for pimozide (Orap), ibid no. 42 pp 76-80, (1983) Summary of adverse drug reactions for sulpiride (Dogmatyl), ibid no. 61 pp 26-34, (1989) Summary of adverse drug reactions for zotepine (Lodopin), ibid no. 95 pp 175-179, (1991) Summary of adverse drug reactions for timiperone (Tolopelon), ibid no. 108 pp 20-22, (1995) Summary of adverse drug reactions for bromperidol (Impromen), ibid suppl. pp 14-16 and (1997) Summary of adverse drug reactions for sultopride (Barnetil), ibid suppl. pp 9-11, Tokyo, Pharmaceutical and Medical Safety Bureau, Ministry of Health and Welfare, Japan
7. Anonymous (1977) Summary of adverse drug reactions for clocapramine (Clofekton), Pharmaceuticals and Medical Devices Safety Information no. 27 pp 6-7, (1980) Summary of adverse drug reactions for pimozide (Orap), ibid no. 42 pp 76-80, (1983) Summary of adverse drug reactions for sulpiride (Dogmatyl), ibid no. 61 pp 26-34, (1989) Summary of adverse drug reactions for zotepine (Lodopin), ibid no. 95 pp 175-179, (1991) Summary of adverse drug reactions for timiperone (Tolopelon), ibid no. 108 pp 20-22, (1995) Summary of adverse drug reactions for bromperidol (Impromen), ibid suppl. pp 14-16 and (1997) Summary of adverse drug reactions for sultopride (Barnetil), ibid suppl. pp 9-11, Tokyo, Pharmaceutical and Medical Safety Bureau, Ministry of Health and Welfare, Japan
8. Anonymous (1977) Summary of adverse drug reactions for clocapramine (Clofekton), Pharmaceuticals and Medical Devices Safety Information no. 27 pp 6-7, (1980) Summary of adverse drug reactions for pimozide (Orap), ibid no. 42 pp 76-80, (1983) Summary of adverse drug reactions for sulpiride (Dogmatyl), ibid no. 61 pp 26-34, (1989) Summary of adverse drug reactions for zotepine (Lodopin), ibid no. 95 pp 175-179, (1991) Summary of adverse drug reactions for timiperone (Tolopelon), ibid no. 108 pp 20-22, (1995) Summary of adverse drug reactions for bromperidol (Impromen), ibid suppl. pp 14-16 and (1997) Summary of adverse drug reactions for sultopride (Barnetil), ibid suppl. pp 9-11, Tokyo, Pharmaceutical and Medical Safety Bureau, Ministry of Health and Welfare, Japan
9. Anonymous (1977) Summary of adverse drug reactions for clocapramine (Clofekton), Pharmaceuticals and Medical Devices Safety Information no. 27 pp 6-7, (1980) Summary of adverse drug reactions for pimozide (Orap), ibid no. 42 pp 76-80, (1983) Summary of adverse drug reactions for sulpiride (Dogmatyl), ibid no. 61 pp 26-34, (1989) Summary of adverse drug reactions for zotepine (Lodopin), ibid no. 95 pp 175-179, (1991) Summary of adverse drug reactions for timiperone (Tolopelon), ibid no. 108 pp 20-22, (1995) Summary of adverse drug reactions for bromperidol (Impromen), ibid suppl. pp 14-16 and (1997) Summary of adverse drug reactions for sultopride (Barnetil), ibid suppl. pp 9-11, Tokyo, Pharmaceutical and Medical Safety Bureau, Ministry of Health and Welfare, Japan
10. Anonymous (1977) Summary of adverse drug reactions for clocapramine (Clofekton), Pharmaceuticals and Medical Devices Safety Information no. 27 pp 6-7, (1980) Summary of adverse drug reactions for pimozide (Orap), ibid no. 42 pp 76-80, (1983) Summary of adverse drug reactions for sulpiride (Dogmatyl), ibid no. 61 pp 26-34, (1989) Summary of adverse drug reactions for zotepine (Lodopin), ibid no. 95 pp 175-179, (1991) Summary of adverse drug reactions for timiperone (Tolopelon), ibid no. 108 pp 20-22, (1995) Summary of adverse drug reactions for bromperidol (Impromen), ibid suppl. pp 14-16 and (1997) Summary of adverse drug reactions for sultopride (Barnetil), ibid suppl. pp 9-11, Tokyo, Pharmaceutical and Medical Safety Bureau, Ministry of Health and Welfare, Japan
11. Anonymous (1977) Summary of adverse drug reactions for clocapramine (Clofekton), Pharmaceuticals and Medical Devices Safety Information no. 27 pp 6-7, (1980) Summary of adverse drug reactions for pimozide (Orap), ibid no. 42 pp 76-80, (1983) Summary of adverse drug reactions for sulpiride (Dogmatyl), ibid no. 61 pp 26-34, (1989) Summary of adverse drug reactions for zotepine (Lodopin), ibid no. 95 pp 175-179, (1991) Summary of adverse drug reactions for timiperone (Tolopelon), ibid no. 108 pp 20-22, (1995) Summary of adverse drug reactions for bromperidol (Impromen), ibid suppl. pp 14-16 and (1997) Summary of adverse drug reactions for sultopride (Barnetil), ibid suppl. pp 9-11, Tokyo, Pharmaceutical and Medical Safety Bureau, Ministry of Health and Welfare, Japan
12. 1 receptor and summary. Ann Rep Pharmacopsychiatr Res Found 25: 243-253
13. Schotte A, Janssen PFM, Gommeren W, Luyten WHML, Van Gompel P, Lesage AS, De Loore K, Leysen JE (1996) Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. Psychopharmacology (Berl) 124: 57-73
14. Pickar D (1994) Serotonin and dopamine abnormalities in schizophrenia. J Clin Psychiatry Monogr Series 12: 10-15
15. Kahn RS, Davis KL (1995) New developments in dopamine and schizophrenia. In: Bloom FE, Kupfer DJ (eds) Psychopharmacology: the fourth generation of progress. Raven Press, New York, pp 1193-1203
16. Kleinlogel H (1989) Effects of the selective alpha 1-adrenoceptor blocker prazosin on EEG sleep and waking stages in the rat. Neuropsychobiology 21: 100-103
17. Rawlins MD (1995) Pharmacovigilance: paradise lost, regained or postponed? J R Coll Physicians Lond 29: 41-49