Facile and highly stereoselective synthesis of the C2-symmetrical diamino diol core-unit of HIV-1 protease inhibitors and of their symmetrical and unsymmetrical analogs from lithiated 2-(dibenzylamino)alkyl carbamates: Oxidative dimerization

Synthesis

Volumn , Issue 9, 1999, Pages 1593-1606

  Weber, B ^a   Kolczewski, S ^a   Frohlich R ^a   Hoppe, D ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

2,5, diamino 1,6 diphenylhexane 3,4 diols; Dioxygen; HIV 1 protease inhibitors; Lithiation; Oxidative coupling; TMEDA mediated deprotonation

Indexed keywords

2,5 DIAMINO 1,6 DIPHENYL 3,4 HEXANEDIOL; DIBENZYLAMINE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DIMERIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; OXIDATION; PROTON TRANSPORT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; X RAY ANALYSIS;

EID: 0032879964     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-1999-3576     Document Type: Article

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