Expression of enzymes of covalent protein modification during regulated and dysregulated proliferation of mammary epithelial cells: PKA, PKC and NMT

Advances in Enzyme Regulation

Volumn 39, Issue 1, 1999, Pages 175-203

  Clegg, Roger A ^b   Gordge, Philip C ^a,b   Miller, William R ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b HANNAH RESEARCH INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE; CARRIER PROTEIN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLYCYLPEPTIDE-N-MYRISTOYL TRANSFERASE; PROTEIN KINASE C; PROTEIN N MYRISTOYLTRANSFERASE; TUMOR PROTEIN;

ANIMAL; ANIMAL TISSUE; BREAST; BREAST EPITHELIUM; BREAST TUMOR; CELL DIVISION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONFERENCE PAPER; CONTROLLED STUDY; CYTOLOGY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; ENZYMOLOGY; EPITHELIUM CELL; FEMALE; HUMAN; METABOLISM; NONHUMAN; PATHOLOGY; PHYSIOLOGY; PREGNANCY; PROTEIN EXPRESSION; PROTEIN PROCESSING; RAT; RAT STRAIN; SIGNAL TRANSDUCTION; UDDER;

EID: 0032879727     PISSN: 00652571     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-2571(98)00011-9     Document Type: Conference Paper

References (88)

1. T. NAGATO, H. YOSHIDA, A. YOSHIDA and Y. UEHARA, A scanning electron microscope study of myoepithelial cells in exocrine glands, Cell Tissue Res. 209, 1-10 (1980).
2. C. H. KNIGHT and M. PEAKER, Development of the mammary gland, J. Reprod. Fertil. 65, 521-536 (1982).
3. J. RUSSO and I. H. RUSSO, Development of the human mammary gland, pp. 67-93 in The Mammary Gland: Development, Regulation and Function (M. C. NEVILLE and C. W. DANIEL, eds.). Plenum Press, New York (1987).
4. D. MEDINA, The mammary gland: a unique organ for the study of development and tumorigenesis, J. Mammary Gland Biol. Neoplasia 1, 5-19 (1996).
5. M. C. NEVILLE, Regulation of mammary gland development and lactation, pp. 103-140 in Lactation (M. C. NEVILLE and M. R. NEIFERT, eds.). Plenum Press, New York (1983).
6. J. A. RILLEMA, Development of the mammary gland and lactation, TEM 5, 149-154 (1994).
7. L. HENNIGHAUSEN and G. W. ROBINSON, Think globally, act locally: the making of a mouse mammary gland, Genes and Dev. 12, 449-455 (1998).
8. R. A. CLEGG, AKAP expression in mammary gland, Biochem. Soc. Trans. 25, S634 (1997).
9. R. A. CLEGG, Expression of N-myristoyl transferase is developmentally regulated in mammary epithelial cells, Biochem. Soc. Trans. 25, S680 (1997).
10. S. J. BEEBE, The cAMP-dependent protein kinases and cAMP signal transduction, Seminars in Cancer Biology 5, 285-294 (1994).
11. K. TASKÉN, R. SOLBERG, K. B. FOSS, B. S. SKÅLHEGG, V. HANSSON and T. JAHNSEN, PKA - cAMP-dependent protein kinase (vertebrates), pp. 58-63 in The Protein Kinase Facts Book I: Protein-Serine Kinases (G. HARDIE and S. HANKS, eds). Academic Press, London (1995).
12. M. QI, M. ZHUO, B. S. SKAL̊HEGG, E. P. BRANDON, E. R. KANDEL, G. S. MCKNIGHT and R. L. IDZERDA, Impaired hippocampal plasticity in mice lacking the CβI catalytic subunit of cAMP-dependent protein-kinase, Proc. Natl. Acad. Sci. USA 93, 1571-1576 (1996).
13. D. E. CUMMINGS, E. P. BRANDON, J. V. PLANAS, K. MOTAMED, R. L. IDZERDA and G. S. MCKNIGHT, Genetically lean mice result from targeted disruption of the RIIβ subunit of protein-kinase-A, Nature 382, 622-626 (1986).
14. M. C. FAUX and J. D. SCOTT, Molecular glue: kinase anchoring and scaffold proteins, Cell 85, 9-12 (1996).
15. J. D. SCOTT and S. MCCARTNEY, Localization of A-kinase through anchor proteins, Mol. Endocrinol. 8, 9-12 (1994).
16. CE) of type I protein kinase A from Caenorhabditis elegans, J Biol. Chem. 273, 14633-14643 (1998).
17. M. C. FAUX and J. D. SCOTT, More on target with protein phosphorylation: conferring specificity by location, TIBS 21, 312-315 (1996).
18. C. S. RUBIN, A-kinase anchor proteins and the intracellular targeting of signals carried by cyclic AMP, Biochim. Biophys. Acta 1224, 467-479 (1994).
19. C. ROSENMUND, D. W. CARR, S. E. BERGESON, G. NILAVER, J. D. SCOTT and G. L. WESTBROOK, Anchoring of protein kinase A is required for modulation of AMPA/kainate receptors on hippocampal neurons, Nature 368, 853-856 (1994).
20. E. A. NIGG, H. HILZ, H. M. EPPENBERGER and F. DUTLY, Rapid and reversible translocation of the catalytic subunit of cAMP-dependent protein kinase type II from the Golgi complex to the nucleus, EMBO J. 4, 2801-2806 (1985).
21. R. G. PANCHAL, S. CHELEY and H. BAYLEY, Differential phosphorylation of neuronal substrates of Aplysia cAMP-dependent protein kinase with alternative N-termini, J. Biol. Chem. 269, 23722-23730 (1994).
22. 2-terminal blocking group of the catalytic subunit of cyclic AMP-dependent protein kinase from bovine cardiac muscle, Proc. Natl. Acad. Sci. USA 79, 6128-6131 (1982).
23. E. J. ADIE, P. H. THOMAS, M. R. MUNDAY and R. A. CLEGG, Subcellular targeting of recombinant and mammalian Cα subunits of cAMP-dependent protein kinase, Biochem. Soc. Trans. 23, 451S (1995).
24. R. A. CLEGG and K. CONNOR, Cyclic AMP-dependent protein kinase in mammary epithelial cells - activity and subcellular distribution are acutely modified by isoprenaline, Cell. Signalling 3, 201-208 (1991).
25. C. H. CLEGG, W. RAN, M. D. UHLER and G. S. MCKNIGHT, A mutation in the catalytic subunit of protein kinase A prevents myristylation but does not inhibit biological activity, J. Biol. Chem. 264, 20140-20146 (1989).
26. J. ZHENG, D. R. KNIGHTON, N.-H. XUONG, S. S. TAYLOR, J. M. SOWADSKI and L. F. TEN EYCK, Crystal structures of the myristylated catalytic subunit of cAMP-dependent protein kinase reveal open and closed conformations, Protein Sci. 2, 1559-1573 (1993).
27. J. E. DUMONT, J.-C. JAUNIAUX and P. P. ROGER, The cAMP-mediated stimulation of cell proliferation, TIBS 14, 67-71 (1989).
28. L. M. GRAVES and J. C. LAWRENCE, Insulin, growth factors and cAMP. Antagonism in the signal transduction pathways, TEM 7, 43-50 (1996).
29. B. S. SKÅLHEGG, B. F. LANDMARK, S. O. DØSKELAND, V. HANSSON, T. LEA and T. JAHNSEN, CyclicAMP-dependent protein kinase type I mediates the inhibitory effects of cAMP on cell replication in human T-lymphocytes, J. Biol. Chem. 267, 15704-15714 (1992).
30. Y. S. CHO-CHUNG, Suppression of malignancy: targeting cyclic AMP signal transducing proteins, Biochem. Soc. Trans. 20, 425-430 (1992).
31. A. MARTI, Z. FENG, B. JEHN, V. DJONOV, G. CHICAIZA, H. J. ALTERMATT and R. JAGGI, Expression and activity of cell cycle regulators during proliferation and programmed cell death in the mammary gland, Cell Death and Differentiation 2, 277-283 (1995).
32. R. JAGGI, A. MARTI, K. GUO, Z. FENG and R. R. FRIIS, Regulation of a physiological apoptosis: mouse mammary involution, J. Dairy Sci. 79, 1074-1084 (1996).
33. O. K. VINTERMYR, B. T. GJERTSEN, M. LANOTTE and S. O. DØSKELAND, Microinjected catalytic subunit of cAMP-dependent protein kinase induces apoptosis in myeloid leukemia (IPC-81) cells, Exptl. Cell Res. 206, 157-161 (1993).
34. J. YANG, R. GUZMAN, J. RICHARDS, W. IMAGAWA, K. MCCORMICK and S. NANDI, Growth factor- and cyclic nucleotide-induced proliferation of normal and malignant mammary epithelial cells in primary culture, Endocrinol. 107, 35-41 (1980).
35. G. B. SILBERSTEIN, P. STRICKLAND, V. TRUMPBOUR, S. COLEMAN and C. W. DANIEL, cAMP stimulates growth and morphogenesis of mouse mammary ducts, Proc. Natl. Acad. Sci. USA 81, 4950-4954 (1984).
36. R. A. GARDNER, M. T. TRAVERS, M. C. BARBER, W. R. MILLER and R. A. CLEGG, Cyclic AMP-dependent protein kinase in rat mammary tissue: expression of catalytic and regulatory subunits throughout pregnancy and lactation, Biochem. J. 301, 807-812 (1994).
37. R. K. SRIVASTAVA, Y. N. LEE, K. NOGUCHI, Y. G. PARK, M. J. C. ELLIS, J.-S. JEONG, S. N. KIM and Y. S. CHO-CHUNG, The RIIβ regulatory subunit of protein kinase A binds to a cAMP response element: an alternative cAMP signalling pathway, Proc. Natl. Acad. Sci. USA 95, 6687-6692 (1998).
38. K. TASKEN, K. B. ANDERSSON, B. K. ERIKSTEIN, V. HANSSON, T. JAHNSEN and H. K. BLOMHOFF, Regulation of growth in a neoplastic B cell line by transfected subunits of 3′5′-cyclic adenosine monophosphate-dependent protein kinase, Endocrinol. 135, 2109-2119 (1994).
39. P. J. PARKER, Protein kinase C: a structurally related family of enzymes, pp. 3-24 in Protein Kinase C: Current Concepts and Future Perspectives (D. S. LESTER and R. M. EPAND, eds). Ellis Horwood, Chichester (1992).
40. D. J. BURNS and R. M. BELL, Lipid regulation of protein kinase C, pp. 25-40 in Protein Kinase C: Current Concepts and Future Perspectives (D. S. LESTER and R. M. EPAND, eds). Ellis Horwood, Chichester (1992).
41. K. CONNOR and R. A. CLEGG, Isoenzymes of protein kinase C in rat mammary tissue: changes in properties and relative amounts during pregnancy and lactation, Biochem. J. 291, 817-824 (1993).
42. D. S. LESTER, Membrane-associated protein kinase C, pp. 80-101 in Protein Kinase C: Current Concepts and Future Perspectives (D. S. LESTER and R. M. EPAND, eds). Ellis Horwood, Chichester (1992).
43. D. MOCHLY-ROSEN, H. KHANER and J. LOPEZ, Identification of intracellular receptor proteins for activated protein kinase C, Proc. Natl. Acad. Sci. USA 88, 3997-4000 (1991).
44. M. D. HOUSLAY, 'Crosstalk': a pivotal role for protein kinase C in modulating relationships between signal transducing pathways, Eur. J. Biochem. 195, 9-27 (1991).
45. B. M. T. BURGERING and J. L. BOS, Regulation of Ras-mediated signalling: more than one way to skin a cat, TIBS 20, 18-22 (1995).
46. H. RASMUSSEN, R. A. CALLE, S. GANESAN, J. I. SMALLWOOD, D. C. THROCKMORTON and W. S. ZAWALICH, Protein kinase C: role in sustained cellular responses, pp. 183-236 in Protein Kinase C: Current Concepts and Future Perspectives (D. S. LESTER and R. M. EPAND, eds). Ellis Horwood, Chichester (1992).
47. M. L. LIU and M. I. SIMON, Regulation by cAMP-dependent protein kinase of a G-protein-mediated phospholipase C, Nature 382, 83-87 (1996).
48. s-stimulated adenylyl cyclases by phorbol ester treatments, J. Biol. Chem. 268, 3829-3832 (1993).
49. T. M. KLAUCK, M. C. FAUX, K. LABUDDA, L. K. LANGEBERG, S. JAKEN and J. D. SCOTT, Coordination of three signalling enzymes by AKAP79, a mammalian scaffold protein, Science 271, 1589-1592 (1996).
50. B. J. GJERTSEN, G. MELLGREN, A. OTTEN, E. MARONDE, H.-G. GENIESSER, B. JASTORFF, O. K. VINTERMYR, G. S. MCKNIGHT and S. O. DØSKELAND, Novel (Rp)-cAMPS analogs as tools for inhibition of cAMP-kinase in cell culture. Basal cAMP-kinase activity modulates interlukin-1β action, J. Biol. Chem. 270, 20599-20607 (1995).
51. H. SUGIYAMA, P. CHEN, M. G. HUNTER and M. V. SITKOVSKY, Perturbation of the expression of the catalytic subunit Cα of Cyclic AMP-dependent protein kinase inhibits TCR-triggered secretion of IL-2 by T helper hybridoma cells, J. Immunol. 158, 171-179 (1997).
52. P. K. BRINDLE and M. C. MONTMINY, The CREB family of transcription activators, Current Opinion in Genetics and Development 2, 199-204 (1992).
53. E. LALLI and P. SASSONE-CORSI, Signal transduction and gene regulation: the nuclear response to cAMP, J. Biol. Chem. 269, 17356-17362 (1994).
54. B. H. MORIMOTO and D. E. KOSHLAND JR., Conditional activation of cAMP signal transduction by protein kinase C. The effect of phorbol esters on adenylyl cyclase in permeabilized and intact cells, J. Biol. Chem. 269, 4065-4069 (1994).
55. D. A. RUDNICK, C. A. MCWHERTER, G. W. GOKEL and J. I. GORDON, Myristoyl-CoA:protein N-myristoyltransferase, Advan. Enzymol. 67, 375-435 (1993).
56. R. A. J. MCILHINNEY, The fats of life: the importance and function of protein acylation, TIBS 15, 386-390 (1990).
57. R. A. J. MCILHINNEY and K. MCGLONE, Evidence for a non-myristoylated pool of the 80-kDa protein-kinase-C substrate of rat-brain, Biochem. J. 271, 681-685 (1990).
58. A. F. G. QUEST, D. J. HARVEY and R. A. J. MCILHINNEY, Myristoylated and nonmyristoylated pools of sea urchin sperm flagellar creatine kinase exist side-by-side: Myristoylation is necessary for efficient lipid association, Biochemistry 36, 6993-7002 (1997).
59. R. S. BHATNAGAR and J. I. GORDON, Understanding covalent modifications of proteins by lipids: where cell biology and biophysics mingle, Trends Cell Biol. 7, 14-20 (1997).
60. M. HARRIS and K. COATES, Identification of cellular proteins that bind to the human immunodeficiency virus type-I nef gene product in vitro - a role for myristylation, J. Gen. Virol. 74, 1581-1589 (1993).
61. src but does not affect tyrosine protein kinase activity, J. Virol. 58, 468-474 (1986).
62. src prevents both myristoylation and morphological transformation, Proc. Natl. Acad. Sci. USA 82, 4625-4628 (1985).
63. M. D. RESH, Myristylation and palmitylation of Src family members: the fats of the matter, Cell 76, 411-413 (1994).
64. R. M. PEITZSH and S. MCLAUGHLIN, Binding of acylated peptides and fatty acids to phospholipid vesicles: pertinence to myristoylated proteins, Biochemistry 32, 10436-10443 (1993).
65. S. MCLAUGHLIN and A. ADEREM, The myristoyl-electrostatic switch: a modulator of reversible protein-membrane interactions. TIBS, 20, 272-276.
66. J. B. AMES, R. ISHIMA, T. TANAKA, J. I. GORDON, L. STRYER and M. IKURA, Molecular mechanics of calcium-myristoyl switches, Nature 389, 198-202 (1997).
67. J. A. BOUTIN, Myristoylation. Cell. Signal. 9, 15-35 (1997).
68. R. S. BHATNAGAR, E. JACKSON-MACHELSKI, C. A. MCWHERTER and J. I. GORDON, Isothermal titration calorimetric studies of Saccharomyces cerevisiae myristoyl-CoA: protein N-myristoyltransferase: determinants of binding energy and catalytic discrimination among acyl-CoA and peptide ligands, J. Biol. Chem. 269, 11045-11053 (1994).
69. R. J. DURONIO, D. A. TOWLER, R. O. HEUCKEROTH and J. I. GORDON, Disruption of the yeast N-myristoyl transferase gene causes recessive lethality, Science 243, 796-800 (1989).
70. C. J. GLOVER, K. D. HARTMAN and R. L. FELSTED, Human N-myristoyltransferase amino-terminal domain involved in targeting the enzyme to the ribosomal subcellular fraction, J. Biol. Chem. 272, 28680-28689 (1997).
71. R. A. J. MCILHINNEY, K. YOUNG, M. EGERTON, R. CAMBLE, A. WHITE and A. SOLOVIEV, Characterization of human and rat brain myristoyl-CoA:protein N-myristoyltransferase: evidence for an alternative splice variant of the enzyme, Biochem. J. 333, 491-495 (1998).
72. D. K. GIANG and B. F. CRAVATT, A second mammalian N-myristoyl transferase, J. Biol. Chem. 273, 6595-6598 (1998).
73. R. A. J. MCILHINNEY, Membrane targeting via protein N-myristoylation, pp. 211-225 in Protein Targeting Protocols (R. A. Clegg, ed.). Humana Press, Totowa (1998).
74. R. V. S. RAJU, R. KAKKAR, R. S. S. DATLA, J. RADHI and R. K. SHARMA, Myristoyl-CoA:protein N-myristoyltransferase from bovine cardiac muscle: molecular cloning, kinetic analysis, and in vitro proteolytic cleavage by m-calpain, Exptl. Cell Res. 241, 23-35 (1998).
75. B. A. MAGNUSON, R. V. S. RAJU, T. N. MOYANA and R. K. SHARMA, Increased N-myristoyltransferase activity observed in rat and human colonic tumours, J. Natl. Cancer Inst. 87, 1630-1635 (1995).
76. R. L. FELSTED, C. J. GLOVER and K. HARTMAN, Protein N-myristoylation as a chemotherapeutic target for cancer, J. Natl. Cancer Inst. 87, 1571-1573 (1995).
77. L. W. SLICE and S. S. TAYLOR, Expression of the catalytic subunit of cAMP-dependent protein kinase in Escherichia coli, J. Biol. Chem. 264, 20940-20946 (1989).
78. W. WEBER, C.-W. VOGEL and H. HILTZ, A new cAMP affinity matrix for the rapid purification of protein kinase regulatory subunits, FEBS Lett. 99, 62-66 (1979).
79. P. C. GORDGE, M. J. HULME and W. R. MILLER, Elevation of protein kinase A and protein kinase C activities in malignant as compared with normal human breast tissue, Eur. J. Cancer 32a, 2120-2126 (1996).
80. R. A. CLEGG and K. A. OTTEY, Cyclic AMP-dependent protein kinase in mammary tissue of the lactating rat. Activity ratio and responsiveness of the target enzymes acetyl-CoA carboxylase and glycogen phosphorylase to β-adrenergic stimulation, Biochem. J. 265, 769-775 (1990).
81. R. A. J. MCILHINNEY and K. MCGLONE, Characterization of a myristoyl CoA:glycylpeptide N-myristoyl transferase activity in rat brain: subcellular and regional distribution, J. Neurochem. 54, 110-117 (1990).
82. R. A. ASPBURY, M. J. FISHER, H. H. REES and R. A. CLEGG, N-myristoylation of the catalytic subunit of cAMP-dependent protein kinase in the free-living nematode Caenorhabditis elegans, Biochem. Biophys. Res. Commun. 238, 523-527 (1997).
83. R. A. CLEGG, R. A. GARDNER, F. LAVIALLE, R. BOISGARD and M. OLLIVIER-BOUSQUET, Casein secretion in mammary tissue: tonic regulation of basal secretion by PKA, Mol. Cell. Endocrinol. 141, 163-177 (1998).
84. R. A. J. MCILHINNEY and K. MCGLONE, Immunocytochemical characterization and subcellular localization of human myristoyl-CoA:protein N-myristoyl transferase in HeLa cells, Exptl. Cell Res. 223, 348-356 (1996).
85. Z. E. HAUSKEN, V. M. COGHLAN and J. D. SCOTT, Overlay, ligand blotting and band-shift techniques to study kinase anchoring, pp. 47-64 in Protein Targeting Protocols (R. A. CLEGG, ed.). Humana Press, Totowa (1998).
86. D. W. CARR, Z. E. HAUSKEN, I. D. C. FRASER, R. D. CONE and J. D. SCOTT, Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain, J. Biol. Chem. 267, 13376-13382 (1992).
87. R. BALLESTER and O. M. ROSEN, Fate of immunoprecipitable protein kinase C in GH3 cells treated with phorbol-12-myristate-13-acetate, J. Biol. Chem. 260, 15194-15199 (1985).
88. R. A. CLEGG and I. MULLANEY, Acute change in the cyclic AMP content of rat mammary acini in vitro. Influence of physiological and pharmacological agents, Biochem. J. 230, 239-246 (1985).