Electrically induced intracellular Ca2+ transient in single ventricular myocytes: A useful parameter for the study of cardiac drugs

Clinical and Experimental Pharmacology and Physiology

Volumn 26, Issue 10, 1999, Pages 835-836

  Wang, H X ^a   Kwan, C Y ^c   Wong, T M ^b  

^a JINZHOU MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

^c NONE

Author keywords

Ca2+ (i) transient; Cardiac myocytes; Contractility

Indexed keywords

CALCIUM; CARBACHOL; CARDIAC AGENT; CARDIOTOXIN; FLUORESCENT DYE; FURA 2 ACETOXYMETHYL ESTER; TETRANDRINE;

CALCIUM CELL LEVEL; CALCIUM CURRENT; CALCIUM TRANSPORT; CONFERENCE PAPER; ELECTROSTIMULATION; HEART MUSCLE CELL; HEART VENTRICLE WALL; MUSCLE CONTRACTION; SPECTROFLUOROMETRY;

ANIMALS; CALCIUM; CARDIOTONIC AGENTS; ELECTRIC STIMULATION; HEART; HEART VENTRICLES;

EID: 0032879677     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1681.1999.03140.x     Document Type: Conference Paper

References (9)

1. 2+ indicators with greatly improved fluorescence. J. Biol. Chem. 1985; 260: 3440-50.
2. 2. Janczewski AM, Lakatta EG. Buffering of calcium influx by sarcoplasmic reticulum during the action potential in guinea-pig ventricular myocytes. J. Physiol. 1993; 471: 343-63.
3. 3. Pappano AJ. Vagal stimulation of the heartbeat: Muscarinic receptor hypothesis. J. Cardiovasc. Electrophysiol. 1991; 2: 262-73.
4. 4. Mubagwa K, Vites AM, Pappano AJ. Stimulant effects of muscarinic receptor agonists in embryonic chick ventricular muscle. Are the effects mediated by protein kinase C? J. Pharmacol. Exp. Ther. 1992; 260: 1323-30.
5. 2+], transient in the single isolated ventricular myocyte of rats. Eur. J. Pharmacol. 1997; 319: 91-9.
6. 2+], transient in the isolated single rat cardiomyocyte. Eur. J. Pharmacol 1997; 319: 115-22.
7. 7. Sun JJ, Walker MJA. Actions of cardiotoxins from the southern Chinese cobra (Naja naja atra) on rat cardiac tissue. Toxicon 1986; 24: 233-45.
8. 8. Huang SJ, Kwan CY. Inhibition by multivalent cations of contraction induced by Chinese cobra venom cardiotoxin in guinea pig papillary muscle. Life Sci. 1996; 59: 55-60.
9. 9. Wang HX, Lau SY, Huang SJ, Kwan CY, Wong TM. Cobra venom cardiotoxin induces perturbations of cytosolic calcium homeostasis and hypercontracture in adult rat ventricular myocytes. J. Mol. Cell. Cardiol. 1997; 29: 2759-70.