Expression of the 17-1A antigen in gastric and gastro-oesophageal junction adenocarcinomas: A potential immunotherapeutic target?

Journal of Clinical Pathology

Volumn 52, Issue 9, 1999, Pages 701-704

  Martin, Iain G ^a   Cutts, Simon G ^a   Birbeck, Kevin ^b   Gray, Sally ^b   Quirke, Philip ^a  

^a LEEDS GENERAL INFIRMARY   (United Kingdom)

^b NONE

Author keywords

Gastric neoplasms; Gastro oesophageal neoplasms; Immunotherapy

Indexed keywords

17 1A ANTIGEN; BW 3622W94; EDRECOLOMAB; EPITHELIAL MEMBRANE ANTIGEN; HUMAN MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER IMMUNOTHERAPY; CLINICAL ARTICLE; CONTROLLED STUDY; ESOPHAGUS CARCINOMA; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LOWER ESOPHAGUS SPHINCTER; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH ADENOCARCINOMA;

EID: 0032879352     PISSN: 00219746     EISSN: None     Source Type: Journal    
DOI: 10.1136/jcp.52.9.701     Document Type: Article

References (8)

1. Forman D, Rider L, eds. Stomach cancer. In: Cancer in Yorkshire: cancer registry report 1996. Leeds: Leeds Graphic Press, 1996:28-9.
2. May J, Melling P, Brown J, et al. Oesophageal cancer in Yorkshire: a regional audit. Gut 1994;35:S14.
3. Blot WJ, Devesa SS, Kneller RW, et al. Rising incidence of adenocarcinoma of the esophagus and gastric cardia. JAMA 1991;265:1287-9.
4. Nakazato H, Koike A, Saji S, et al. Efficacy of immunochemotherapy as adjuvant treatment after curative resection of gastric cancer. Study Group of Immunochemotherapy with PSK for Gastric Cancer. Lancet 1994;334:1122-6.
5. Riethmuller G, Schneider-Gadicke E, Schlimok G, et al. Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes' C colorectal carcinoma. Lancet 1994;343:1177-83.
6. Gottlinger HG, Funke I, Johnson JP, et al. The epithelial cell surface antigen 17-1A, a target for antibody-mediated tumour therapy: its biochemical nature, tissue distribution and recognition by different monoclonal antibodies. Int J Cancer 1986;38:47-53.
7. Glaxo Wellcome Research and Development. Panorex - Investigators Brochure. Uxbridge: Glaxo Wellcome, 1996:5.
8. Riethmuller G, Holz E, Schlimok G, et al. Monoclonal antibody therapy for resected Dukes C colorectal cancer: seven year outcome of a multicenter randomised trial. J Clin Oncol 1998;16:1788-94.