Immunohistochemical localization of transforming growth factor-α and transforming growth factor-β during early human fetal prostate development

Journal of Urology

Volumn 162, Issue 2, 1999, Pages 509-513

  Raghow, Sharan ^a   Shapiro, Ellen ^a   Steiner, Mitchell S ^a  

^a NONE

Author keywords

Androgens; Epithelium; Growth substances; Mesoderm; Prostate

Indexed keywords

ANDROGEN; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3;

ANDROGEN BLOOD LEVEL; ARTICLE; EPITHELIUM; FETUS; HORMONAL REGULATION; HORMONE ACTION; HORMONE RELEASE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MESENCHYME; PRIORITY JOURNAL; PROSTATE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SEXUAL DEVELOPMENT;

EID: 0032879221     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(05)68617-X     Document Type: Article

References (23)

1. Jirasek, J. E.: The relationship between the structure of the testis and differentiation of the external genitalia and phenotype in man. In: Endocrinology of the Testes. Ciba Symposium, 16: 3, 1967.
2. Xia, T. G., Blackburn, W. R. and Gardner, W. A., Jr.: Fetal prostate growth and development. Ped. Path., 10: 527, 1990.
3. Cunha, G. R.: Epithelio-mesenchymal interactions in primordial gland structures which become responsive to androgenic stimulation. Anat. Rec., 172: 179, 1972.
4. Takeda, H. and Chang, C.: Immunohistochemical and in-situ hybridization analysis of androgen receptor expression during the development of the mouse prostate gland. J. Endocr., 129: 83, 1991.
5. Tenniswood, M.: Role of epithelial-stromal interactions in the control of gene expression in the prostate: an hypothesis. Prostate, 9: 375, 1986.
6. Chang, S. M. and Chung, L. W. K.: Interaction between prostatic fibroblast and epithelial cells in culture: role of androgen. Endocrinology, 125: 2719, 1989.
7. McKeehan, W. L., Adams, P. S. and Rosser, M. P.: Direct mitogenic effects of insulin, epidermal growth factor, glucocorticoid, cholera toxin, unknown pituitary factors and possibly prolactin, but not androgen, on normal rat prostate epithelial cells in serum-free, primary cell culture. Cancer Res., 44: 1998, 1984.
8. Taylor, T. B. and Ramsdell, J. S.: Transforming growth factor-α and its receptor are expressed in the epithelium of the rat prostate gland. Endocrinology, 133: 1306, 1993.
9. Steiner, M. S.: Review of peptide growth factors in benign prostatic hyperplasia and urologic malignancy. J. Urol., 153: 1085, 1995.
10. Tutrone, R. F., Jr., Ball, R. A., Ornitz, D. M., Leder, P. and Richie, J. P.: Benign prostatic hyperplasia in a transgenic mouse: a new hormonally sensitive investigatory model. J. Urol., 149: 633, 1993.
11. Kyprianou, N. and Isaacs, J. T.: Expression of transforming growth factor-beta in the rat ventral prostate during castration-induced programmed cell death. Mol. Endocr., 3: 1515, 1989.
12. Donjacour, A. A. and Cunha, G. R.: The effect of androgen deprivation on branching morphogenesis in the mouse prostate. Dev. Biol., 128: 1, 1988.
13. Story, M. T.: Polypeptide modulators of prostatic growth and development. Cancer Surv., 11: 123, 1991.
14. Reyes, F. I., Boroditsky, R. S., Winter, J. S. and Faiman, C.: Studies on human sexual development. II. Fetal and maternal serum gonadotropin and sex steroid concentrations. J. Clin. Endocr. Metab., 38: 612, 1974.
15. Alarid, E. T., Cunha, G. R., Young, P. and Nicoll, C. S.: Evidence for an organ-and sex-specific role of basic fibroblast growth factor in the development of the fetal mammalian reproductive tract. Endocrinology, 129: 2148, 1991.
16. George, F. W. and Peterson, K. G.: Salpha-dihydrotestosterone formation is necessary for embryogenesis of the rat prostate. Endocrinology, 122: 1159, 1988.
17. Imperato-McGinley, J., Binienda, Z., Arthur, A., Mininberg, D. T., Vaughan, E. D., Jr. and Quimby, F. W.: The development of a male pseudo-hermaphroditic rat using an inhibitor of the enzyme 5α-reductase. Endocrinology, 116: 807, 1985.
18. Cunha, G. R., Donjacour, A. A., Cooke, P. S., Mee, S., Bigsby, R. M., Higgins, S. J. and Sugimura, Y.: The endocrinology and developmental biology of the prostate. Endocr. Rev., 8: 338, 1987.
19. Cunha, G. R. and Donjacour, A. A.: Mesenchymal-epithelial interactions in the growth and development of the prostate. Cancer Treat. Res., 46: 159, 1989.
20. Derynck, R., Lindquist, P. B., Bringman, T. S., Wilcox, J. N., Elder, J. T., Fisher, G. L., Vorhees, J. J., Moses, H. L., Pittelkow, M. R. and Coffey, R. J., Jr.: Expression of the transforming growth factor-alpha gene in tumor cells and normal tissue. Cancer Cells, 7: 297, 1989.
21. Sandgren, E. P., Luetteke, N. C., Palmiter, R. D., Brinster, R. L. and Lee, D. C.: Overexpression of TGFα in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia and carcinoma of the breast. Cell, 61: 1121, 1990.
22. Itoh, N., Patel, U., Cupp, A. S. and Skinner, M. K.: Developmental and hormonal regulation of transforming growth factor-beta1 (TGFbeta 1), -2, and -3 gene expression in isolated prostatic epithelial and stromal cells: epidermal growth factor and TGFbeta interactions. Endocrinology, 139: 1378, 1998.
23. Sanford, L. P., Ormsby, I., Gittenberger-de-Groot, A. C., Sariola, H., Friedman, R., Boivin, G. P., Cardell, E. L. and Doetschman, T.: TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes. Development, 124: 2659, 1997.