Decoding time-varying calcium signals by the postsynaptic biochemical network: Computer simulations of molecular kinetics

Neurocomputing

Volumn 26-27, Issue , 1999, Pages 29-38

  Kubota, Yoshihisa ^a   Bower, James M ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Calcium calmodulin kinase II; Dynamical system theory; Enzyme kinetics; Synaptic function

Indexed keywords

BIFURCATION (MATHEMATICS); BIOCHEMISTRY; COMPUTER SIMULATION; ENZYME KINETICS; FUNCTIONAL ELECTRIC STIMULATION; MATHEMATICAL MODELS; MOLECULAR DYNAMICS; NEUROPHYSIOLOGY; NUMERICAL ANALYSIS; PERTURBATION TECHNIQUES; PROTEINS;

CALCIUM CALMODULIN KINASE; DECODING TIME VARYING CALCIUM SIGNALS; DYNAMICAL SYSTEM THEORY; MOLECULAR KINETICS; POSTSYNAPTIC BIOCHEMICAL NETWORK; SYNAPTIC FUNCTION;

MEDICAL COMPUTING;

ADENYLATE CYCLASE; CALCINEURIN; CALMODULIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHODIESTERASE; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR 1; PROTEIN KINASE (CALCIUM,CALMODULIN) II; RAS PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; ARTIFICIAL NEURAL NETWORK; COMPUTER SIMULATION; FREQUENCY MODULATION; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; MOLECULAR DYNAMICS; NERVE CONDUCTION; POSTSYNAPTIC MEMBRANE; PRIORITY JOURNAL; SIGNAL PROCESSING; SPIKE WAVE;

EID: 0032879171     PISSN: 09252312     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-2312(99)00085-5     Document Type: Article

References (15)

1. Barria A., Muller D., Derkach V., Griffith L.C., Soderling T.R. Regulatory phosphorylation of AMPA-type glutamate receptors by CaMKII during long-term potentiation. Science. 276:1997;2042-2045.
2. Benke T.A., Luthi A., Isaac J.T.R., Collingridge G.L. Modulation of AMPA receptor unitary conductance by synaptic activity. Nature. 393:1998;793-797.
3. Blitzer R.D., Conner J.H., Brown G.P., Wong T., Shenolikar S., Iyengar R., Landau E.M. Gating of CaMKII by cAMP regulated protein phosphatase activity during LTP. Science. 280:1998;1940-1943.
4. J. Chen H., Rojassoto M., Oguni A., Kennedy M.B. A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM Kinase II. Neuron. 20:1998;895-904.
5. Dosemeci A., Albers R.W. A mechanism for synaptic frequency detection through autophosphorylation of CaM Kinase II. Biophys. J. 70:1996;2493-2501.
6. B Kennedy M. The biochemistry of synaptic regulation in the central nervous system. Annu. Rev. Biochem. 63:1994;571-600.
7. Kennedy M.B. Signal transduction molecule at the glutamatergic postsynaptic membrane. Brain Res. Rev. 26:1998;243-257.
8. 2+ oscillations. Science. 279:1998;227-230.
9. Lisman J. A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory. Proc. Natl. Acad. Sci. 86:1989;9574-9578.
10. Lundh D. A kinetic model on calcium residues and facilitation. Brain Res. Bull. 45:1998;589-597.
11. Meyer T., Hanson H.I., Stryer L., Schulman H. Calmodulin trapping by calcium-calmodulin-dependent protein kinase. Science. 256:1992;1199-1202.
12. Michelson S., Schulman H. CaM kinase: a model for its activation and dynamics. J. Theoret. Biol. 171:1994;281-290.
13. Putkey J.A., Waxham M.N. A peptide model for calmodulin trapping by calcium/calmodulin-dependent protein kinase II. J. Biol. Chem. 271:1996;29619-29623.
14. 2+/calmodulin-dependent protein kinase II by protein phosphatase-1 and protein phosphatase 2a. J. Neurochem. 68:1997;2119-2128.
15. Waxham M.N., Putkey J.A. A mechanism for calmodulin (CaM) trapping by CaM-kinase II defined by a family of CaM-binding peptides. J. Biol. Chem. 273:1998;17579-17584.