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Volumn 64, Issue 3, 1999, Pages 611-623

Substantia nigra: The involvement of central and peripheral benzodiazepine receptors in physical dependence on diazepam as evidenced by behavioral and EEG effects

Author keywords

Central benzodiazepine receptors; EEG; Flumazenil; Focal injection; Peripheral benzodiazepine receptors; PK 11195; Precipitated withdrawal; Substantia nigra

Indexed keywords

4 AMINOBUTYRIC ACID; BENZODIAZEPINE RECEPTOR; DIAZEPAM; FLUMAZENIL; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE;

EID: 0032879005     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(99)00125-2     Document Type: Article
Times cited : (3)

References (84)
  • 1
    • 0025563374 scopus 로고
    • Effect of chronic treatment of Ro 15-1788 and its withdrawal on cortical and hippocampal EEG activity in rats
    • Aley K.O., Kulkarni S.K. Effect of chronic treatment of Ro 15-1788 and its withdrawal on cortical and hippocampal EEG activity in rats. Indian J. Exp. Biol. 28:1990;1149-1159.
    • (1990) Indian J. Exp. Biol. , vol.28 , pp. 1149-1159
    • Aley, K.O.1    Kulkarni, S.K.2
  • 4
    • 0018242937 scopus 로고
    • Pharmacological characteristics of benzodiazepine receptors in the brain
    • Braestrup C., Squires R.F. Pharmacological characteristics of benzodiazepine receptors in the brain. Eur. J. Pharmacol. 48:1978;263-270.
    • (1978) Eur. J. Pharmacol. , vol.48 , pp. 263-270
    • Braestrup, C.1    Squires, R.F.2
  • 6
    • 0027276847 scopus 로고
    • Chronic benzodiazepine administration XI. Concurrent administration of PK11195 attenuates lorazepam discontinuation effects
    • Byrnes, J. J.; Miller, L. G.; Perkins, K.; Greenblatt, D. J.; Shader, R. I. Chronic benzodiazepine administration XI. Concurrent administration of PK11195 attenuates lorazepam discontinuation effects. Neuropsychopharmacology 8:267-273; 1993.
    • (1993) Neuropsychopharmacology , vol.8 , pp. 267-273
    • Byrnes, J.J.1    Miller, L.G.2    Perkins, K.3    Greenblatt, D.J.4    Shader, R.I.5
  • 7
    • 0024502037 scopus 로고
    • Effects of diazepam and two beta-carbolines on epileptic activity and on EEG and behavior in rats with absence seizures
    • Coenen A.M., van Luijtelaar E.L. Effects of diazepam and two beta-carbolines on epileptic activity and on EEG and behavior in rats with absence seizures. Pharmacol. Biochem. Behav. 32:1989;27-35.
    • (1989) Pharmacol. Biochem. Behav. , vol.32 , pp. 27-35
    • Coenen, A.M.1    Van Luijtelaar, E.L.2
  • 9
    • 0028987522 scopus 로고
    • Effect of zolpidem on γ-aminobutyric acid (GABA)-induced inhibition predicts the interaction of ethanol with GABA on individual neurons in several rat brain regions
    • Criswell H.E., Simson P.E., Knapp D.J., Devaud L.L., McCown T.J., Duncan G.E., Morrow A.L., Breese G.R. Effect of zolpidem on γ-aminobutyric acid (GABA)-induced inhibition predicts the interaction of ethanol with GABA on individual neurons in several rat brain regions. J. Pharmacol. Exp. Ther. 273:1995;526-536.
    • (1995) J. Pharmacol. Exp. Ther. , vol.273 , pp. 526-536
    • Criswell, H.E.1    Simson, P.E.2    Knapp, D.J.3    Devaud, L.L.4    McCown, T.J.5    Duncan, G.E.6    Morrow, A.L.7    Breese, G.R.8
  • 10
    • 0022443602 scopus 로고
    • Evidence for species differences in "peripheral" benzodiazepine receptors: An autoradiographic study
    • Cymerman U., Pazos A., Palacios J.M. Evidence for species differences in "peripheral" benzodiazepine receptors. An autoradiographic study Neurosci. Lett. 66:1986;153-158.
    • (1986) Neurosci. Lett. , vol.66 , pp. 153-158
    • Cymerman, U.1    Pazos, A.2    Palacios, J.M.3
  • 11
    • 0000735715 scopus 로고
    • Substantia nigra
    • G. Paxinos. San Diego: Academic Press
    • Fallon J.H., Loughlin S.E. Substantia nigra. Paxinos G. The rat nervous system. 1995;215-237 Academic Press, San Diego.
    • (1995) The Rat Nervous System , pp. 215-237
    • Fallon, J.H.1    Loughlin, S.E.2
  • 12
    • 0022406721 scopus 로고
    • The effects of PK11195, a ligand for benzodiazepine binding sites, in animal tests of anxiety and stress
    • File S.E., Pellow S. The effects of PK11195, a ligand for benzodiazepine binding sites, in animal tests of anxiety and stress. Pharmacol. Biochem. Behav. 23:1985;737-741.
    • (1985) Pharmacol. Biochem. Behav. , vol.23 , pp. 737-741
    • File, S.E.1    Pellow, S.2
  • 13
    • 0022656375 scopus 로고
    • Intrinsic actions of the benzodiazepine receptor antagonist Ro 15-1788
    • File S.E., Pellow S. Intrinsic actions of the benzodiazepine receptor antagonist Ro 15-1788. Psychopharmacology (Berlin). 88:1986;1-11.
    • (1986) Psychopharmacology (Berlin) , vol.88 , pp. 1-11
    • File, S.E.1    Pellow, S.2
  • 14
    • 0028802204 scopus 로고
    • Pharmacodynamic modeling of the electroencephalographic effects of flumazenil in healthy volunteers sedated with midazolam
    • Fiset P., Lemmens H.L., Egan T.E., Shafer S.L., Stanski D.R. Pharmacodynamic modeling of the electroencephalographic effects of flumazenil in healthy volunteers sedated with midazolam. Clin. Pharmacol. Ther. 58:1995;567-582.
    • (1995) Clin. Pharmacol. Ther. , vol.58 , pp. 567-582
    • Fiset, P.1    Lemmens, H.L.2    Egan, T.E.3    Shafer, S.L.4    Stanski, D.R.5
  • 15
    • 0026648083 scopus 로고
    • Five subtypes of type A γ-aminobutyric acid receptors identified in neurons by double and triple immunofluorescence staining with subunit-specific antibodies
    • Fritschy J.M., Benke D., Mertens S., Oertel W.H., Bachi T., Mohler H. Five subtypes of type A γ-aminobutyric acid receptors identified in neurons by double and triple immunofluorescence staining with subunit-specific antibodies. Proc. Natl. Acad. Sci. USA. 89:1992;6726-6730.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 6726-6730
    • Fritschy, J.M.1    Benke, D.2    Mertens, S.3    Oertel, W.H.4    Bachi, T.5    Mohler, H.6
  • 16
    • 0022344350 scopus 로고
    • Continuous release of diazepam: Electrophysiological, biochemical and behavioral consequences
    • Gallager D.W., Malcolm A.B., Anderson S.A., Gonsalves S.F. Continuous release of diazepam. Electrophysiological, biochemical and behavioral consequences Brain Res. 342:1985;26-36.
    • (1985) Brain Res. , vol.342 , pp. 26-36
    • Gallager, D.W.1    Malcolm, A.B.2    Anderson, S.A.3    Gonsalves, S.F.4
  • 17
    • 0023098070 scopus 로고
    • 35S]t-butylbicyclophosphorothionate binding to a chloride ionosphore in rat brain via a novel Ro5 4864 binding site
    • 35S]t-butylbicyclophosphorothionate binding to a chloride ionosphore in rat brain via a novel Ro5 4864 binding site. J. Pharmacol. Exp. Ther. 240:1987;747-753.
    • (1987) J. Pharmacol. Exp. Ther. , vol.240 , pp. 747-753
    • Gee, K.W.1
  • 18
    • 0023681634 scopus 로고
    • Steroid modulation of the chloride ionophore in rat brain: Structure-activity requirements, regional dependence and mechanism of action
    • Gee K.W., Bolger M.B., Brinton R.E., Coirini H., McEwen B.S. Steroid modulation of the chloride ionophore in rat brain. Structure-activity requirements, regional dependence and mechanism of action J. Pharmacol. Exp. Ther. 246:1988;803-812.
    • (1988) J. Pharmacol. Exp. Ther. , vol.246 , pp. 803-812
    • Gee, K.W.1    Bolger, M.B.2    Brinton, R.E.3    Coirini, H.4    McEwen, B.S.5
  • 19
    • 0023259683 scopus 로고
    • Diazepam and desmethyldiazepam differ in their affinities and efficacies at "central" and "peripheral" benzodiazepine receptors
    • Gobbi M., Barone D., Mennini T., Garatini S. Diazepam and desmethyldiazepam differ in their affinities and efficacies at "central" and "peripheral" benzodiazepine receptors. J. Pharm. Pharmacol. 39:1987;388-391.
    • (1987) J. Pharm. Pharmacol. , vol.39 , pp. 388-391
    • Gobbi, M.1    Barone, D.2    Mennini, T.3    Garatini, S.4
  • 21
    • 0001792955 scopus 로고
    • Binding characteristics of the receptor and coupling to transport proteins
    • E. Giesen-Crouse. London: Academic Press
    • Hertz L. Binding characteristics of the receptor and coupling to transport proteins. Giesen-Crouse E. Peripheral benzodiazepine receptors. 1993;27-59 Academic Press, London.
    • (1993) Peripheral Benzodiazepine Receptors , pp. 27-59
    • Hertz, L.1
  • 22
    • 0024952607 scopus 로고
    • Determination of pharmacodynamics of diazepam by quantitative pharmaco-EEG
    • Iwaya N., Morita Y., Miyoshi K. Determination of pharmacodynamics of diazepam by quantitative pharmaco-EEG. Jpn. J. Psychiatr. Neurol. 43:1989;675-684.
    • (1989) Jpn. J. Psychiatr. Neurol. , vol.43 , pp. 675-684
    • Iwaya, N.1    Morita, Y.2    Miyoshi, K.3
  • 23
    • 0029085373 scopus 로고
    • Flunitrazepam and nordiazepam slowly released from silastic capsules induce physical dependence in rat
    • Jing X., Wala E.P., Sloan J.W. Flunitrazepam and nordiazepam slowly released from silastic capsules induce physical dependence in rat. Drug Alcohol Depend. 39:1995;63-67.
    • (1995) Drug Alcohol Depend. , vol.39 , pp. 63-67
    • Jing, X.1    Wala, E.P.2    Sloan, J.W.3
  • 25
    • 0030933685 scopus 로고    scopus 로고
    • The peripheral benzodiazepine receptor is a sensitive indicator of domoic acid neurotoxicity
    • Kuhlmann A.C., Guilarte T.R. The peripheral benzodiazepine receptor is a sensitive indicator of domoic acid neurotoxicity. Brain Res. 751:1997;281-288.
    • (1997) Brain Res. , vol.751 , pp. 281-288
    • Kuhlmann, A.C.1    Guilarte, T.R.2
  • 27
    • 0345525910 scopus 로고    scopus 로고
    • Pharmacologic interactions of diazepam and flumazenil on cortical EEG and behavior in rats
    • Lee M.G., Park E.J., Kim S.K. Pharmacologic interactions of diazepam and flumazenil on cortical EEG and behavior in rats. Soc. Neurosci. Abstr. 23:1997;949.
    • (1997) Soc. Neurosci. Abstr. , vol.23 , pp. 949
    • Lee, M.G.1    Park, E.J.2    Kim, S.K.3
  • 28
    • 0021335399 scopus 로고
    • Pharmacokinetic studies on Ro 15-1788, a benzodiazepine receptor ligand, in the brain of the rat
    • Lister R.G., Greenblatt D.J., Abernathy D.R., File S.E. Pharmacokinetic studies on Ro 15-1788, a benzodiazepine receptor ligand, in the brain of the rat. Brain Res. 290:1984;183-186.
    • (1984) Brain Res. , vol.290 , pp. 183-186
    • Lister, R.G.1    Greenblatt, D.J.2    Abernathy, D.R.3    File, S.E.4
  • 29
    • 0024156181 scopus 로고
    • Modifications of brain electrical activity after activation of the benzodiazepine receptor types in rats and rabbits
    • Longo V.G., Massotti M., DeMedici D., Valerio A. Modifications of brain electrical activity after activation of the benzodiazepine receptor types in rats and rabbits. Pharmacol. Biochem. Behav. 29:1988;785-790.
    • (1988) Pharmacol. Biochem. Behav. , vol.29 , pp. 785-790
    • Longo, V.G.1    Massotti, M.2    Demedici, D.3    Valerio, A.4
  • 30
    • 0344522800 scopus 로고    scopus 로고
    • Seizure suppression in kindling epilepsy by grafts of fetal GABAergic neurons in rat substantia nigra
    • Loscher W., Ebert U., Lehmann H., Rosenthal C., Nikkhah G. Seizure suppression in kindling epilepsy by grafts of fetal GABAergic neurons in rat substantia nigra. Soc. Neurosci. Abstr. 22:1996;1655.
    • (1996) Soc. Neurosci. Abstr. , vol.22 , pp. 1655
    • Loscher, W.1    Ebert, U.2    Lehmann, H.3    Rosenthal, C.4    Nikkhah, G.5
  • 31
    • 0026050401 scopus 로고
    • Pharmacokinetic-pharmacodynamic modeling of the electroencephalographic effects of benzodiazepines. Correlation with receptor binding and anticonvulsant activity
    • Mandema J.W., Sansom L.N., Dios-Vieitez M.C., Hollander-Jansen M., Danhof M. Pharmacokinetic-pharmacodynamic modeling of the electroencephalographic effects of benzodiazepines. Correlation with receptor binding and anticonvulsant activity. J. Pharmacol. Exp. Ther. 257:1991;472-478.
    • (1991) J. Pharmacol. Exp. Ther. , vol.257 , pp. 472-478
    • Mandema, J.W.1    Sansom, L.N.2    Dios-Vieitez, M.C.3    Hollander-Jansen, M.4    Danhof, M.5
  • 32
    • 0026737667 scopus 로고
    • Electroencephologram effect measures and relationships between pharmacokinetics and pharmacodynamics of centrally acting drugs
    • Mandema J.W., Danhof M. Electroencephologram effect measures and relationships between pharmacokinetics and pharmacodynamics of centrally acting drugs. Clin. Pharmacokinet. 23:1992;191-215.
    • (1992) Clin. Pharmacokinet. , vol.23 , pp. 191-215
    • Mandema, J.W.1    Danhof, M.2
  • 33
    • 0026502975 scopus 로고
    • Differences in intrinsic efficacy of benzodiazepines are reflected in their concentration-EEG effect relationship
    • Mandema J.W., Kuck M.T., Danhof M. Differences in intrinsic efficacy of benzodiazepines are reflected in their concentration-EEG effect relationship. Br. J. Pharmacol. 105:1992;164-170.
    • (1992) Br. J. Pharmacol. , vol.105 , pp. 164-170
    • Mandema, J.W.1    Kuck, M.T.2    Danhof, M.3
  • 34
    • 0026755623 scopus 로고
    • In vivo modeling of the pharmacodynamic interaction between benzodiazepines which differ in intrinsic efficacy
    • Mandema J.W., Kuck M.T., Danhof M. In vivo modeling of the pharmacodynamic interaction between benzodiazepines which differ in intrinsic efficacy. J. Pharmacol. Exp. Ther. 261:1992;56-61.
    • (1992) J. Pharmacol. Exp. Ther. , vol.261 , pp. 56-61
    • Mandema, J.W.1    Kuck, M.T.2    Danhof, M.3
  • 35
    • 0026513875 scopus 로고
    • In vivo characterization of the pharmacodynamic interaction of a benzodiazepine agonist and antagonist: Midazolam and flumazenil
    • Mandema J.W., Tukker E., Danhof M. In vivo characterization of the pharmacodynamic interaction of a benzodiazepine agonist and antagonist. midazolam and flumazenil J. Pharmacol. Exp. Ther. 260:1992;36-44.
    • (1992) J. Pharmacol. Exp. Ther. , vol.260 , pp. 36-44
    • Mandema, J.W.1    Tukker, E.2    Danhof, M.3
  • 36
    • 0025280619 scopus 로고
    • Two kinds of spatiotemporal EEG changes after discontinuation of benzodiazepine, medazepam
    • Manmaru S., Matsuura M. Two kinds of spatiotemporal EEG changes after discontinuation of benzodiazepine, medazepam. Jpn. J. Psychiatr. Neurol. 44:1990;85-90.
    • (1990) Jpn. J. Psychiatr. Neurol. , vol.44 , pp. 85-90
    • Manmaru, S.1    Matsuura, M.2
  • 38
    • 0025241110 scopus 로고
    • Precipitated abstinence in orally dosed benzodiazepine-dependent dogs
    • Martin W.R., Sloan J.W., Wala E. Precipitated abstinence in orally dosed benzodiazepine-dependent dogs. J. Pharmacol. Exp. Ther. 255:1990;744-755.
    • (1990) J. Pharmacol. Exp. Ther. , vol.255 , pp. 744-755
    • Martin, W.R.1    Sloan, J.W.2    Wala, E.3
  • 40
    • 0026559766 scopus 로고
    • Physical dependence on diazepam: Precipitation of abstinence syndromes by peripheral and central benzodiazepine receptor antagonists
    • Martinez J.A., Fargeas M.J., Bueno L. Physical dependence on diazepam. Precipitation of abstinence syndromes by peripheral and central benzodiazepine receptor antagonists Pharmacol. Biochem. Behav. 41:1992;461-464.
    • (1992) Pharmacol. Biochem. Behav. , vol.41 , pp. 461-464
    • Martinez, J.A.1    Fargeas, M.J.2    Bueno, L.3
  • 41
    • 0025344077 scopus 로고
    • 3) in the tolerance to the electroencephalographic efftects of benzodiazepines in rats: Comparison of diazepam and clonazepam
    • 3) in the tolerance to the electroencephalographic efftects of benzodiazepines in rats. Comparison of diazepam and clonazepam Pharmacol. Biochem. Behav. 35:1990;933-936.
    • (1990) Pharmacol. Biochem. Behav. , vol.35 , pp. 933-936
    • Massotti, M.1    Mele, L.2    Luca, C.D.3
  • 42
    • 0022981686 scopus 로고
    • Autoradiographic localization of subcomponents of the macromolecular GABA receptor complex
    • McCabe R.T., Wamsley J.K. Autoradiographic localization of subcomponents of the macromolecular GABA receptor complex. Life Sci. 39:1986;1937-1945.
    • (1986) Life Sci. , vol.39 , pp. 1937-1945
    • McCabe, R.T.1    Wamsley, J.K.2
  • 43
    • 0021691143 scopus 로고
    • Chronic administration of diazepam to rats causes changes in EEG patterns and in coupling between GABA receptors and benzodiazepine binding sites in vitro
    • Mele L., Sagratella S., Massotti M. Chronic administration of diazepam to rats causes changes in EEG patterns and in coupling between GABA receptors and benzodiazepine binding sites in vitro. Brain Res. 323:1984;93-102.
    • (1984) Brain Res. , vol.323 , pp. 93-102
    • Mele, L.1    Sagratella, S.2    Massotti, M.3
  • 45
    • 0026711078 scopus 로고
    • Chronic benzodiazepine administration. X. Concurrent administration of the peripheral-type benzodiazepine ligand PK 11195 attentuates chronic effects of lorazepam
    • Miller L.G., Galpern W.R., Byrnes J.J., Greenblatt D.J., Shader R.I. Chronic benzodiazepine administration. X. Concurrent administration of the peripheral-type benzodiazepine ligand PK 11195 attentuates chronic effects of lorazepam. J. Pharmacol. Exp. Ther. 261:1992;285-289.
    • (1992) J. Pharmacol. Exp. Ther. , vol.261 , pp. 285-289
    • Miller, L.G.1    Galpern, W.R.2    Byrnes, J.J.3    Greenblatt, D.J.4    Shader, R.I.5
  • 47
    • 0019829187 scopus 로고
    • Benzodiazepine antagonist Ro 15-1788: Binding characteristics and interation with drug-induced changes in dopamine turnover and cerebellar cGMP levels
    • Mohler H., Burkard W.P., Keller H.H., Richards J.G., Haefely G. Benzodiazepine antagonist Ro 15-1788. Binding characteristics and interation with drug-induced changes in dopamine turnover and cerebellar cGMP levels J. Neurochem. 37:1981;714-722.
    • (1981) J. Neurochem. , vol.37 , pp. 714-722
    • Mohler, H.1    Burkard, W.P.2    Keller, H.H.3    Richards, J.G.4    Haefely, G.5
  • 48
    • 0017661950 scopus 로고
    • Benzodiazepine receptor: Demonstration in the central nervous system
    • Mohler H., Okada T. Benzodiazepine receptor. Demonstration in the central nervous system Science. 198:1977;849-851.
    • (1977) Science , vol.198 , pp. 849-851
    • Mohler, H.1    Okada, T.2
  • 50
    • 0029932796 scopus 로고    scopus 로고
    • Peripheral-type benzodiazepine receptors in association with epileptic seizures in EL mice
    • Nakamoto Y., Watabe S., Shiotani T., Yoshii M. Peripheral-type benzodiazepine receptors in association with epileptic seizures in EL mice. Brain Res. 717:1996;91-98.
    • (1996) Brain Res. , vol.717 , pp. 91-98
    • Nakamoto, Y.1    Watabe, S.2    Shiotani, T.3    Yoshii, M.4
  • 51
    • 0024334539 scopus 로고
    • Comparison of changes in the EEG of freely moving rats induced by enciprazine, buspirone and diazepam
    • Nickel B., Szelenyi I. Comparison of changes in the EEG of freely moving rats induced by enciprazine, buspirone and diazepam. Neuropharmacology. 28:1989;799-803.
    • (1989) Neuropharmacology , vol.28 , pp. 799-803
    • Nickel, B.1    Szelenyi, I.2
  • 54
    • 0022544176 scopus 로고
    • Peripheral benzodiazepine binding sites in human brain and kidney: Autoradiographic studies
    • Pazos A., Cymerman U., Probst A., Palacios J.M. Peripheral benzodiazepine binding sites in human brain and kidney. Autoradiographic studies Neurosci. Lett. 66:1986;147-152.
    • (1986) Neurosci. Lett. , vol.66 , pp. 147-152
    • Pazos, A.1    Cymerman, U.2    Probst, A.3    Palacios, J.M.4
  • 56
    • 0019469317 scopus 로고
    • Withdrawal from long-term benzodiazepine treatment
    • Petursson H., Lader M.H. Withdrawal from long-term benzodiazepine treatment. Br. Med. J. 283:1981;643-645.
    • (1981) Br. Med. J. , vol.283 , pp. 643-645
    • Petursson, H.1    Lader, M.H.2
  • 57
    • 0026015891 scopus 로고
    • Chronic flurazepam differentially regulates a behavioral effect of GABA agonists
    • Ramsey V.A., Tietz E.I., Rosenberg H.C. Chronic flurazepam differentially regulates a behavioral effect of GABA agonists. Pharmacol. Biochem. Behav. 38:1991;659-663.
    • (1991) Pharmacol. Biochem. Behav. , vol.38 , pp. 659-663
    • Ramsey, V.A.1    Tietz, E.I.2    Rosenberg, H.C.3
  • 58
    • 0020459992 scopus 로고
    • Effects of benzodiazepines on single unit activity in the substantia nigra pars reticulata
    • Ross R.J., Waszczak B.L., Lee E.K., Walters J.R. Effects of benzodiazepines on single unit activity in the substantia nigra pars reticulata. Life Sci. 31:1982;1025-1035.
    • (1982) Life Sci. , vol.31 , pp. 1025-1035
    • Ross, R.J.1    Waszczak, B.L.2    Lee, E.K.3    Walters, J.R.4
  • 60
    • 0024598252 scopus 로고
    • Peripheral benzodiazepine binding sites
    • Saano V., Rago L., Raty M. Peripheral benzodiazepine binding sites. Pharmacol. Ther. 41:1989;503-514.
    • (1989) Pharmacol. Ther. , vol.41 , pp. 503-514
    • Saano, V.1    Rago, L.2    Raty, M.3
  • 61
    • 0024373705 scopus 로고
    • Cerebral-activating (EEG) properties of two inverse agonists and of an antagonist at the benzodiazepine receptor in the rat
    • Santucci V., Fournier M., Worms P., Keane P., Biziere K. Cerebral-activating (EEG) properties of two inverse agonists and of an antagonist at the benzodiazepine receptor in the rat. Naunyn Schmiedebergs Arch. Pharmacol. 340:1989;93-100.
    • (1989) Naunyn Schmiedebergs Arch. Pharmacol. , vol.340 , pp. 93-100
    • Santucci, V.1    Fournier, M.2    Worms, P.3    Keane, P.4    Biziere, K.5
  • 62
  • 63
    • 0345385097 scopus 로고    scopus 로고
    • PK 11195 (PK)-evoked withdrawal in diazepam (DZ)-dependent rats: Effect of dose of PK, DZ and gender
    • Sloan J.W., Wala E.P., Jing X. PK 11195 (PK)-evoked withdrawal in diazepam (DZ)-dependent rats. Effect of dose of PK, DZ and gender Soc. Neurosci. Abstr. 23:1997;2392.
    • (1997) Soc. Neurosci. Abstr. , vol.23 , pp. 2392
    • Sloan, J.W.1    Wala, E.P.2    Jing, X.3
  • 64
    • 84880917004 scopus 로고    scopus 로고
    • Regional CNS heterogeneities in flumazenil-precipitated withdrawal in diazepam-dependent female rats
    • Sloan J.W., Wala E.P., Jing X. Regional CNS heterogeneities in flumazenil-precipitated withdrawal in diazepam-dependent female rats. FASEB J. 12:1998;161.
    • (1998) FASEB J. , vol.12 , pp. 161
    • Sloan, J.W.1    Wala, E.P.2    Jing, X.3
  • 65
    • 0008118786 scopus 로고    scopus 로고
    • Effect of repeated (daily vs weekly) administration of PK 11195 on precipitated withdrawal scores in diazepam-dependent male and female rats
    • Sloan J.W., Wala E.P., Jing X. Effect of repeated (daily vs weekly) administration of PK 11195 on precipitated withdrawal scores in diazepam-dependent male and female rats. Soc. Neurosci. Abstr. 24:1998;196.
    • (1998) Soc. Neurosci. Abstr. , vol.24 , pp. 196
    • Sloan, J.W.1    Wala, E.P.2    Jing, X.3
  • 66
    • 0345385096 scopus 로고    scopus 로고
    • Diazepam-treated female rats: Flumazenil- And PK 11195-induced withdrawal in the hippocampus CA1
    • Sloan J.W., Wala E., Jing X., Holtman J.R., Milliken B. Diazepam-treated female rats. Flumazenil- and PK 11195-induced withdrawal in the hippocampus CA1 Pharmacol. Biochem. Behav. 60:1998;1-10.
    • (1998) Pharmacol. Biochem. Behav. , vol.60 , pp. 1-10
    • Sloan, J.W.1    Wala, E.2    Jing, X.3    Holtman, J.R.4    Milliken, B.5
  • 67
    • 0023866764 scopus 로고
    • Behavioral measurement of benzodiazepine tolerance and GABAergic subsensitivity in the substantia nigra pars reticulata
    • Tietz E.I., Rosenberg H.C. Behavioral measurement of benzodiazepine tolerance and GABAergic subsensitivity in the substantia nigra pars reticulata. Brain Res. 438:1988;41-51.
    • (1988) Brain Res. , vol.438 , pp. 41-51
    • Tietz, E.I.1    Rosenberg, H.C.2
  • 68
    • 0022645203 scopus 로고
    • Autoradiographic localization of benzodiazepine receptor downregulation
    • Tietz E.I., Rosenberg H.C., Chiu T.H. Autoradiographic localization of benzodiazepine receptor downregulation. J. Pharmacol. Exp. Ther. 236:1986;284-292.
    • (1986) J. Pharmacol. Exp. Ther. , vol.236 , pp. 284-292
    • Tietz, E.I.1    Rosenberg, H.C.2    Chiu, T.H.3
  • 69
    • 0023914072 scopus 로고
    • Effects of chronic flurazepam treatment on firing rate of rat substantia nigra pars reticulata neurons
    • Tyma J.L., Rosenberg H.C., Tietz E.I., Chiu T.H. Effects of chronic flurazepam treatment on firing rate of rat substantia nigra pars reticulata neurons. Brain Res. 453:1988;344-348.
    • (1988) Brain Res. , vol.453 , pp. 344-348
    • Tyma, J.L.1    Rosenberg, H.C.2    Tietz, E.I.3    Chiu, T.H.4
  • 70
    • 0024155669 scopus 로고
    • Electroencephalographic changes after short-term exposure to agonists of benzodiazepine receptors in the rat
    • Valerio A., Massotti M. Electroencephalographic changes after short-term exposure to agonists of benzodiazepine receptors in the rat. Pharmacol. Biochem. Behav. 29:1988;791-795.
    • (1988) Pharmacol. Biochem. Behav. , vol.29 , pp. 791-795
    • Valerio, A.1    Massotti, M.2
  • 71
    • 0021954118 scopus 로고
    • Characterization of peripheral-type benzodiazepine recognition sites in the rat spinal cord
    • Villiger J.W. Characterization of peripheral-type benzodiazepine recognition sites in the rat spinal cord. Neuropharmacology. 24:1985;95-98.
    • (1985) Neuropharmacology , vol.24 , pp. 95-98
    • Villiger, J.W.1
  • 72
    • 0030580548 scopus 로고    scopus 로고
    • Intrathecally administered flumazenil and PK 11195 precipitate abstinence syndrome in freely moving diazepam dependent rats
    • Wala E.P., Sloan J.W., Jing X., Holtman P.H. Intrathecally administered flumazenil and PK 11195 precipitate abstinence syndrome in freely moving diazepam dependent rats. Drug Alcohol Depend. 43:1996;169-177.
    • (1996) Drug Alcohol Depend. , vol.43 , pp. 169-177
    • Wala, E.P.1    Sloan, J.W.2    Jing, X.3    Holtman, P.H.4
  • 73
    • 0030752020 scopus 로고    scopus 로고
    • Dorsal raphe and substantia nigra response to flumazenil in diazepam-dependent rats
    • Wala E.P., Sloan J.W., Jing X. Dorsal raphe and substantia nigra response to flumazenil in diazepam-dependent rats. Pharmacol. Biochem. Behav. 58:1997;221-229.
    • (1997) Pharmacol. Biochem. Behav. , vol.58 , pp. 221-229
    • Wala, E.P.1    Sloan, J.W.2    Jing, X.3
  • 74
    • 0030802656 scopus 로고    scopus 로고
    • Comparison of abstinence syndromes precipitated by flumazenil and PK 11195 in female diazepam-dependent rats
    • Wala E.P., Sloan J.W., Jing X. Comparison of abstinence syndromes precipitated by flumazenil and PK 11195 in female diazepam-dependent rats. Psychopharmacology (Berlin). 133:1997;214-223.
    • (1997) Psychopharmacology (Berlin) , vol.133 , pp. 214-223
    • Wala, E.P.1    Sloan, J.W.2    Jing, X.3
  • 75
    • 0022973093 scopus 로고
    • Effects of anticonvulsant drugs on substantia nigra pars reticulata neurons
    • Waszczak B.L., Lee E.K., Walters J.R. Effects of anticonvulsant drugs on substantia nigra pars reticulata neurons. J. Pharmacol. Exp. Ther. 239:1986;601-611.
    • (1986) J. Pharmacol. Exp. Ther. , vol.239 , pp. 601-611
    • Waszczak, B.L.1    Lee, E.K.2    Walters, J.R.3
  • 76
    • 0027421715 scopus 로고
    • Divergent alterations in γ-aminobutyric acid/benzodiazepine responses of male and ovariectomized rats after chronic benzodiazepine agonist exposure: Electrophysiological analysis of substantia nigra pars reticulata neurons
    • Wilson M.A. Divergent alterations in γ-aminobutyric acid/benzodiazepine responses of male and ovariectomized rats after chronic benzodiazepine agonist exposure. Electrophysiological analysis of substantia nigra pars reticulata neurons J. Pharmacol. Exp. Ther. 266:1993;774-779.
    • (1993) J. Pharmacol. Exp. Ther. , vol.266 , pp. 774-779
    • Wilson, M.A.1
  • 77
    • 0027319619 scopus 로고
    • Gonadectomy and sex modulate spontaneous activity of substantia nigra pars reticulata neurons without modifying GABA/benzodiazepine responsiveness
    • Wilson M.A. Gonadectomy and sex modulate spontaneous activity of substantia nigra pars reticulata neurons without modifying GABA/benzodiazepine responsiveness. Life Sci. 53:1993;217-225.
    • (1993) Life Sci. , vol.53 , pp. 217-225
    • Wilson, M.A.1
  • 78
    • 0023275567 scopus 로고
    • Effects of chronic diazepam exposure on GABA sensitivity and on benzodiazepine potentiation of GABA-mediated responses of substantia nigra pars reticulata neurons of rats
    • Wilson M.A., Gallager D.W. Effects of chronic diazepam exposure on GABA sensitivity and on benzodiazepine potentiation of GABA-mediated responses of substantia nigra pars reticulata neurons of rats. Eur. J Pharmacol. 136:1987;333-343.
    • (1987) Eur. J Pharmacol. , vol.136 , pp. 333-343
    • Wilson, M.A.1    Gallager, D.W.2
  • 79
    • 0023781316 scopus 로고
    • Ro 15-1788-induced seizures in rats continually exposed to diazepam for prolonged periods
    • Wilson M.A., Gallager D.W. Ro 15-1788-induced seizures in rats continually exposed to diazepam for prolonged periods. Epilepsy Res. 2:1988;14-19.
    • (1988) Epilepsy Res. , vol.2 , pp. 14-19
    • Wilson, M.A.1    Gallager, D.W.2
  • 80
    • 0024597859 scopus 로고
    • Responses of substantia nigra pars reticulata neurons to benzodiazepine ligands after acute and prolonged diazepam exposure. I. Modulation of γ-aminobutyric acid sensitivity
    • Wilson M.A., Gallager D.W. Responses of substantia nigra pars reticulata neurons to benzodiazepine ligands after acute and prolonged diazepam exposure. I. Modulation of γ-aminobutyric acid sensitivity. J. Pharmacol. Exp. Ther. 248:1989;879-885.
    • (1989) J. Pharmacol. Exp. Ther. , vol.248 , pp. 879-885
    • Wilson, M.A.1    Gallager, D.W.2
  • 81
    • 0024591225 scopus 로고
    • Responses of substantia nigra pars reticulata neurons to benzodiazepine ligands after acute and prolonged diazepam exposure. II. Modulation of firing rate
    • Wilson M.A., Gallager D.W. Responses of substantia nigra pars reticulata neurons to benzodiazepine ligands after acute and prolonged diazepam exposure. II. Modulation of firing rate. J. Pharmacol. Exp. Ther. 248:1989;886-891.
    • (1989) J. Pharmacol. Exp. Ther. , vol.248 , pp. 886-891
    • Wilson, M.A.1    Gallager, D.W.2
  • 82
    • 0026878098 scopus 로고
    • Benzodiazepines: Use, abuse and consequences
    • Woods J.H., Katz J.L., Winger G. Benzodiazepines. Use, abuse and consequences Pharmacol. Rev. 44:1992;169-189.
    • (1992) Pharmacol. Rev. , vol.44 , pp. 169-189
    • Woods, J.H.1    Katz, J.L.2    Winger, G.3
  • 83
    • 0019500391 scopus 로고
    • Multiple benzodiazepine receptor localization by light microscopic radiohistochemistry
    • Young W.S., Niehoff D., Kuhar M.J., Beer B., Lippa A.S. Multiple benzodiazepine receptor localization by light microscopic radiohistochemistry. J. Pharmacol. Exp. Ther. 216:1981;425-430.
    • (1981) J. Pharmacol. Exp. Ther. , vol.216 , pp. 425-430
    • Young, W.S.1    Niehoff, D.2    Kuhar, M.J.3    Beer, B.4    Lippa, A.S.5
  • 84
    • 0024359810 scopus 로고
    • Injection of benzodiazepines but not GABA or muscimol into pars reticulata of substantia nigra suppresses pentylenetetrazol
    • Zhang H., Rosenberg H.C., Tietz E.I. Injection of benzodiazepines but not GABA or muscimol into pars reticulata of substantia nigra suppresses pentylenetetrazol. Brain Res. 488:1989;73-79.
    • (1989) Brain Res. , vol.488 , pp. 73-79
    • Zhang, H.1    Rosenberg, H.C.2    Tietz, E.I.3


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