Characterization of Neurospora crassa mutants isolated following repeat-induced point mutation of the beta subunit of fatty acid synthase

Current Genetics

Volumn 36, Issue 3, 1999, Pages 147-152

  Goodrich Tanrikulu, Marta ^a,c   Jacobson, David J ^b   Stafford, Allan E ^a   Lin, Jiann Tsyh ^a   McKeon, Thomas A ^a  

^a WESTERN REGIONAL RESEARCH CENTER   (United States)

^b STANFORD UNIVERSITY   (United States)

^c Calgene LLC   (United States)

Author keywords

Fatty acid biosynthesis; Filamentous fungi; Neurospora crassa; Repeat induced point mutation

Indexed keywords

CERULENIN; FATTY ACID; FATTY ACID SYNTHASE;

ARTICLE; CONTROLLED STUDY; ENZYME SUBUNIT; FATTY ACID DESATURATION; FATTY ACID SYNTHESIS; FUNGUS GROWTH; FUNGUS MUTANT; INFERTILITY; NEUROSPORA CRASSA; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; SEXUAL DEVELOPMENT;

ALLELES; FATTY ACID SYNTHETASE COMPLEX; FATTY ACIDS; MUTAGENESIS; NEUROSPORA CRASSA; PHENOTYPE; POINT MUTATION; TRANSFORMATION, GENETIC;

EID: 0032877457     PISSN: 01728083     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002940050484     Document Type: Article

References (32)

1. Austin B, Tyler BM (1990) Strategies for high-efficiency cotransformation of Neurospora crassa. Exp Mycol 14:9-17
2. Brown DW, Adams TH, Keller NP (1996) Aspergillus has distinct fatty acid synthases for primary and secondary metabolism. Proc Natl Acad Sci USA 93:14873-14877
3. Burk AG, Srb AM (1978) Perithecial submersion: a method for detecting the effect of compounds on ascus development. Neurospora Newslett 25:13
4. Burkl G, Castroph H, Schweizer E (1972) Mapping of a complex gene locus coding for part of the Saccharomyces cerevisiae fatty acid synthetase multienzyme complex. Mol Gen Genet 119:315-322
5. Coté GG, Brody S (1987) Circadian rhythms in Neurospora crassa: membrane composition of a mutant defective in temperature compensation. Biochim Biophys Acta 898:23-36
6. Davis RH, deSerres FJ (1978) Genetic and microbiological research techniques for Neurospora crassa. Methods Enzymol 17A:79-143
7. - mutation. J Bacteriol 124:524-533
8. Friedman KJ (1977) Role of lipids in the Neurospora crassa membrane I. Influence of fatty acid composition on membrane lipid phase transitions. J Membrane Biol 32:33-47
9. Goodrich-Tanrikulu M, Stafford AE, Lin J-T, Makapugay MI, Fuller G, McKeon TA (1994) Fatty acid biosynthesis in novel ufa mutants of Neurospora crassa. Microbiology 140:2683-2690
10. Hasslacher M, Ivessa AS, Paltauf F, Kohlwein SD (1993) Acetyl-CoA carboxylase from yeast is an essential enzyme and is regulated by factors that control phospholipid metabolism. J Biol Chem 268:10946-10952
11. Henry SA, Keith AD (1971) Saturated fatty acid requirer of Neurospora crassa. J Bacteriol 106:174-182
12. Mattern D (1985) Unsaturated fatty acid isomers: effects on the circadian rhythm of a fatty-acid-deficient Neurospora crassa-mutant. Arch Biochem Biophys 237:402-407
13. McKeon TA, Goodrich-Tanrikulu M, Lin J-T, Stafford A (1997) Pathways for fatty acid elongation and desaturation in Neurospora crassa. Lipids 32:1-5
14. Mikolajczyk S, Brody S (1990) De novo fatty acid synthesis mediated by acyl-carrier protein in Neurospora crassa mitochondria. Eur J Biochem 187:431-437
15. Oakley CE, Weil CF, Kretz PL, Oakley BR (1987) Cloning of the riboB locus of Aspergillus nidulans. Gene 53:293-298
16. Omura S (1976) The antibiotic cerulenin, a novel tool for biochemistry as an inhibitor of fatty acid synthesis. Bacteriol Rev 40:681-697
17. Pall ML (1993) The use of Ignite (Basta; glufosinate; phosphinothricin) to select transformants of bar-containing plasmids in Neurospora crassa. Fungal Genet Newslett 40:58
18. Pall ML, Brunelli JP (1993) A series of six compact fungal transformation vectors containing polylinkers with multiple unique restriction sites. Fungal Genet Newslett 40:59-62
19. Pandit NN, Russo VEA (1992) Reversible inactivation of a foreign gene, hph, during the asexual cycle in Neurospora crassa transformants. Mol Gen Genet 234:412-422
20. ml strain as a helper component in heterokaryons. Neurospora Newslett 31:41-42
21. Perkins DD, Pollard VC (1987) Newly mapped chromosomal loci of Neurospora crassa. Fungal Genet Newslett 34:52-53
22. Perkins DD, Glassey M, Bloom BA (1962) New data on markers and rearrangements in Neurospora. Can J Genet Cytol 4:187-205
23. Roggenkamp R, Numa S, Schweizer E (1980) Fatty acid-requiring mutant of Saccharomyces cerevisiae defective in acetyl-CoA carboxylase. Proc Natl Acad Sci USA 77:1814-1817
24. Saitoh S, Takahashi K, Nabeshima K, Yamashita Y, Nakaseko Y, Hirata A, Yanagida M (1996) Aberrant mitosis in fission yeast mutants defective in fatty acid synthetase and acetyl CoA carboxylase. J Cell Biol 134:949-961
25. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning: a laboratory manual, 2nd edn. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York
26. Schneider R, Brors B, Massow M, Weiss H (1997) Mitochondrial fatty acid synthesis: a relic of endosymbiontic origin and a specialized means for respiration. FEBS Lett 407:249-252
27. Schweizer E, Werkmeister K, Jam MK (1978) Fatty acid biosynthesis in yeasts. Mol Cell Biochem 21:95-106
28. Selker EU, Cambareri EB, Jensen BC, Haack KR (1987) Rearrangement of duplicated DNA in specialized cells of Neurospora. Cell 51:741-752
29. Selker E, Cambareri E, Garrett P, Jensen B, Haack K, Foss E, Turpen C, Singer M, Kinsey J (1989) Use of RIP to inactivate genes in Neurospora crassa. Fungal Genet Newslett 36:76-77
30. Stafford AE, McKeon TA, Goodrich-Tanrikulu M (1998) Conversion of palmitate to unsaturated fatty acids differs in a Neurospora crassa mutant with impaired fatty acid synthase activity. Lipids 33:303-306
31. Vollmer SJ, Yanofsky C (1986) Efficient cloning of genes of Neurospora crassa. Proc Natl Acad Sci USA 83:4869-4873
32. Yamashita RA, Stuart WD (1996) Identification of several novel Neurospora crassa genes in the λ-ZAP I and λ-ZAP II libraries. Fungal Genet Newslett 43:66-67