Alterations of p53 in tumorigenic human bronchial epithelial cells correlate with metastatic potential

Carcinogenesis

Volumn 20, Issue 8, 1999, Pages 1529-1533

  Piao, Chang Q ^a   Willey, James C ^b   Hei, Tom K ^a  

^a Columbia University ^*  (United States)

^b MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

ARTICLE; BRONCHUS MUCOSA; CARCINOGENESIS; CONTROLLED STUDY; DNA SEQUENCE; GENE MUTATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; METASTASIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE STRAND CONFORMATION POLYMORPHISM; TUMOR CELL LINE;

NASA DISCIPLINE RADIATION HEALTH; NON-NASA CENTER;

ANIMALS; CELL LINE, TRANSFORMED; DNA MUTATIONAL ANALYSIS; EPITHELIAL CELLS; GENES, P53; HUMANS; LUNG NEOPLASMS; MICE; MICE, NUDE; NEOPLASMS, RADIATION-INDUCED; POINT MUTATION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; TUMOR CELLS, CULTURED;

EID: 0032877207     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/20.8.1529     Document Type: Article

References (30)

1. Harris, C.C. and Hollstein, M. (1992) p53 tumor suppressor gene. Principles Pract. Oncol, 6, 1-12.
2. Scheffner, M., Werness, B.A., Huibregtse, J.M., Levine, A.J. and Howley, P.M. (1990) The E6 oncoprotein encoded by human papillomavirus type 16 and 18 promotes the degradation of p53. Cell, 63, 1129-1136.
3. Lane, D.P. and Crawford, L. (1979) T-antigen is bound to a host protein in SV-40 transformed cells. Nature, 278, 261-263.
4. Hei, T.K., Komatsu, K. and Hall, E.J. (1988) Oncogenic transformation by charged particles of defined LET. Carcinogenesis, 9, 747-750.
5. Hall, E.J. and Hei, T.K. (1991) Modulating factors in expression of radiation induced oncogenic transformation. Environ. Health Perspect., 88, 149-153.
6. Hei, T.K., Piao, C.Q., Willey, J.C., Sutter, T. and Hall, E.J. (1994) Malignant transformation of human bronchial epithelial cells by radon-simulated alpha particles [Accelerated paper]. Carcinogenesis, 15, 431-437.
7. Hei, T.K., Piao, C.Q., Sutter, T., Willey, J.C. and Suzuki, K. (1996) Cellular and molecular alterations in human epithelial cells transformed by high LET radiation. Adv. Space Res., 18, 137-148.
8. Crook, T. and Vousden, K.H. (1992) Properties of p53 mutations detected in primary and secondary cervical cancers suggest mechanisms of metastasis and involvement of environmental carcinogens. J. Eur. Mol. Biol. Organ., 11, 3935-3940.
9. Greenblatt, M.S., Bennett, W.P., Hollstein, M. and Harris, C.C. (1994) Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res., 54, 4855-4878.
10. Hei, T.K., Piao, C.Q., Han, E., Sutter, T. and Willy, J.C. (1996) Radon-induced neoplastic transformation of human bronchial epithelial cells. Radiat. Oncol. Invest., 3, 398-403.
11. Kozlowski, J.M., Fidler, I.J., Campell, D., Xu, Z.L., Kaighn, M.E. and Hart, I.R. (1984) Metastatic behavior of human tumor cell lines grown in the nude mice. Cancer Res., 44, 3522-3529.
12. Miller, S.A., Dykes, D.D. and Polesky, H.F. (1988) A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res., 16, 1215-1219.
13. Zhu, L.X., Waldren, C.A., Vannais, D. and Hei, T.K. (1996) Cellular and molecular analysis of mutagenesis induced by charged particles of defined LET. Radiat. Res., 145, 251-259.
14. Marchetti, A., Buttitta, F., Merlo, G. et al. (1993) p53 alterations in non-small cell lung cancers correlate with metastatic involvment of hilar and mediastinal lymph nodes. Cancer Res., 53, 2846-2851.
15. Bradford, M.M. (1976) A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein dye binding. Anal. Biochem., 72, 248-254.
16. Willey, J.C., Broussoud, A., Sleemi, A., Bennett, W.P., Cerutti, P. and Curtis, C.C. (1991) Immortalization of human bronchial epithelial cells by papillomaviruses 16 or 18. Cancer Res., 51, 5370-5377.
17. Weaver, D., Hei, T.K., Hukku, B., McRaven, J. and Willey, J.A (1997) Cytogenetic and molecular genetic analysis of BEP2D human bronchial epithelial and carcinogenesis model. Carcinogenesis, 18, 1251-1257.
18. Hei, T.K., Wu, L.J. and Piao, C.Q. (1997) Malignant transformation of immortalized human bronchial epithelial cells by asbestos fibers. Environ. Health Perspect., 105, 1085-1088.
19. Tsuda, H. and Hirohashi, S. (1992) Frequent occurrence of p53 gene mutations in uterine cancer at advanced clinical stage and with aggressive histological phenotypes. Jpn. J. Cancer Res., 83, 1513-1519.
20. Busby-Earle, R.M., Steel, C.M., Williams, A.R., Cohen, B. and Bird, C.C. (1992) Papillomavirus, p53 and cervical cancer. Lancet, 339, 1350.
21. Butz, K., Shahabeddin, L., Geisen, C., Spitkovsky, D., Ullmann, A. and Hoppe-Seyler, F. (1995) Functional p53 protein in human papillomavirus-positive cells. Oncogene, 10, 927-936.
22. Vousden, K.H. (1994) Interactions between papillomavirus proteins and tumor suppressor gene products. Adv. Cancer Res., 64, 1-24.
23. Taylor, T.A., Watson, M.A., Devereux, T.R., Michels, R.Y., Saccomanno, C. and Anderson, M. (1994) Mutational hotspot in the p53 gene in radon-associated lung tumors from uranium miners. Lancet, 343, 86-87.
24. Vahakangas, K.H., Samet, J.M., Metcalf, R.A., Welsh, J.A., Bennett, W.P., Lane, D.P. and Harris, C.C. (1992) Mutations of the p53 and ras genes in radon-associated lung cancer from uranium miners. Lancet, 339, 576-580.
25. Lo, Y.M.D., Darby, S., Noakes, L., Whitley, E., Silcocks, P.B.S., Fleming, K.A. and Bell, J.I. (1995) Screening for codon 249 p53 mutation in lung cancer associated with domestic radon exposure. Lancet, 345, 60.
26. Evans, H.H. (1994) Failla Memorial Lecture. The prevalence of multilocus lesions in radiation induced mutants. Radiat. Res., 137, 131-144.
27. Hei, T.K., Wu, L.J., Liu, S.X., Vannais, D., Waldren, C.A. and Randers-Pehrson, G. (1997). Mutagenic effects of a single and an exact number of alpha particles in mammalian cells. Proc. Natl Acad. Sci. USA, 94, 3765-3770.
28. Jenkins, J.R., Rudge, K., Chumakov, P. and Currie, G.A. (1985) The cellular oncogene p53 can be activated by mutagenesis. Nature, 317, 816-818.
29. Levine, A.J., Momand, J. and Finlay, C.A. (1991) The p53 tumor suppressor gene. Nature, 351, 453-456.
30. Soussi, T., Legros, Y., Lubin, R., Ory, K. and Schlichtholz, B. (1994) Mulifactorial analysis of p53 alteration in human cancer: a review. Int. J. Cancer, 57, 1-9.