The effect of time of administration of phenytoin on its serum levels and pharmacodynamic parameters in patients of generalised tonic clonic seizures

Biological Rhythm Research

Volumn 30, Issue 3, 1999, Pages 321-331

  Yegnanarayan, Radha ^a   Kulkarni, H G ^a   Wadia, R S ^b  

^a B J MEDICAL COLLEGE   (India)

^b Sassoon General Hospital   (India)

Author keywords

Generalised tonic clonic seizures; Pharmacokinetics; Phenytoin; Serum levels; Time of administration

Indexed keywords

ANTICONVULSIVE AGENT; ETHOSUXIMIDE; LIDOCAINE; PHENOBARBITAL; PHENYTOIN; THEOPHYLLINE; VALPROIC ACID;

ADOLESCENT; AREA UNDER THE CURVE; CHRONOPHARMACOLOGY; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE SEVERITY; DRUG ABSORPTION; DRUG BLOOD LEVEL; FALLING; GRAND MAL EPILEPSY; HUMAN; MALE; ORAL DRUG ADMINISTRATION; PARESTHESIA; SEIZURE; VERTIGO;

EID: 0032876878     PISSN: 09291016     EISSN: None     Source Type: Journal    
DOI: 10.1076/brhm.30.3.321.3055     Document Type: Conference Paper

References (11)

1. Benet L, Mitchell J, Shoiner L (1990): The Pharmacological Basis of Therapeutics. Pergamon Press, New York, 31-32.
2. Cocks D, Critchley E, Hayward H, Owen V, Mawer G, Woodcock B (1975): Control of epilepsy with a single daily dose of phenytoin sodium. Br J Clin Pharmacol 2: 449-553.
3. Gerson B, Frances Bell D, Sum C, Broussard L, Stearns Frings C (1984): Antiepileptic Agents : Clinical Chemistry 30: 1, 105-109.
4. Goo R, Moore J, Greenberg E, Alasarke N (1987). Circadian variation in gastric emptying of meals in humans. Gastroenterology 93: 573-578.
5. Lemmer B, Nord E, Bohnes S, Kaiser R (1991). Chronopharmacokinetics and cardiovascular effects of nifedipine. Chronobiol Internat 8: 484-491.
6. Loisen P, Genrand B, Levy R, Akbaraly R, Brachet-Lierman A, Guyot M, Morselli P (1990): Diurnal variations in steady state plasma concentrations of valproic acid in epileptic patients. Clin Pharmacokin 7: 544-552.
7. Pisani F, Oteri G, Capute M, Di Perrir (1990): Chronopharmacology in Therapy of the Epilepsies. Raven Press, New York, p. 129-142.
8. Rall T, Schleifer L (1990): The Pharmacological Basis of Therapeutics. Pergamon Press, New York, 436-432.
9. Reinberg A (1987): Antiepileptic agents. Chronobiologia: July-Sept. XIV: 305.
10. Reinberg A, Pauchet E, Ruff E (1986): The advantage of once daily evening versus morning sustained theophylline dosing for nocturnal asthma. Ann Review Chronopharmacology 147-150.
11. Strandjord R, Johanesson (1974): One daily dose of diphenylhydantoin for patients with epilepsy. Epilepsia 15: 317-327.