The influence of intravenous omeprazole on intragastric pH and outcomes in patients with peptic ulcer bleeding after successful endoscopic therapy - A prospective randomized comparative trial

Hepato-Gastroenterology

Volumn 46, Issue 28, 1999, Pages 2183-2188

  Tseng, Guan Ying ^a   Lin, Hwai Jeng ^a,b   Lin, Hsiao Yi ^a   Perng, Chin Lin ^a   Lee, Fa Yauh ^a   Lo, Wen Ching ^a   Chang, Full Young ^a   Lee, Shou Dong ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b VGH TAIPEI   (Taiwan)

Author keywords

Intragastric pH; Omeprazole; Peptic ulcer bleeding

Indexed keywords

OMEPRAZOLE;

ADULT; AGED; ARTICLE; BLOOD TRANSFUSION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ENDOSCOPIC THERAPY; FEMALE; GASTROINTESTINAL HEMORRHAGE; HEMOSTASIS; HOSPITALIZATION; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; MORTALITY; PEPTIC ULCER; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; STOMACH PH;

ADULT; AGED; AGED, 80 AND OVER; ANTI-ULCER AGENTS; DRUG ADMINISTRATION SCHEDULE; FEMALE; GASTRIC ACIDITY DETERMINATION; HEMOSTASIS, ENDOSCOPIC; HUMANS; INJECTIONS, INTRAVENOUS; MALE; MIDDLE AGED; OMEPRAZOLE; PEPTIC ULCER HEMORRHAGE; RECURRENCE;

EID: 0032876151     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Longstreth GF: Epidemiology of hospitalization for acute upper gastrointestinal hemorrhage: a population based study. Am J Gastroenterol 1995; 90:206-210.
2. Rockall TA, Logan RFA, Devlin HB, Northfield TC: Incidence and mortality from acute upper gastrointestinal haemorrhage in the United Kingdom. BMJ 1995; 331:222-226.
3. Consensus Development Panel: Consensus statement on therapeutic endoscopy and bleeding ulcers. Gastrointest Endosc 1990; 36:S62-65.
4. Lin HJ, Lee FY, Kang WM, Tsai YT, Lee SD, Lee CH: Heat probe thermocoagulation and pure alcohol injection in massive peptic ulcer haemorrhage: a prospective, randomized controlled trial. Gut 1990; 31:753-757.
5. Llach J, Bordas JM, Salmeron JM, Panes J, Garcia-Pagan JC, Feu F, Navasa M, Mondelo F, Pique JM, Mas A, Teres J, Rodes J: A prospective randomized trial of heater probe thermocoagulation versus injection therapy in peptic ulcer hemorrhage. Gastrointest Endosc 1996; 43:117-120.
6. Lin HJ, Wang K, Perng CL, Lee CH, Lee SD: Heat probe thermocoagulation and multipolar electrocoagulation for arrest of peptic ulcer bleeding, a prospective, randomized comparative trial. J Clin Gastroenterol 1995; 21:99-102.
7. Gralnek IM, Jensen DM, Kovacs TOG, Jutabha R, Jensen ME, Cheng S, et al: An economic analysis of patients with active arterial peptic ulcer hemorrhage treated with endoscopic heater probe, injection sclerosis, or surgery in a prospective, randomized trial. Gastrointest Endosc 1997; 46:105-112.
8. Allan R, Dykes P: A study of the factors influencing mortality rates from gastrointestinal haemorrhage. Q J Med 1976; 45:533-550.
9. Turner IB, Jones M, Piper DW: Factors influencing mortality from bleeding peptic ulcers. Scand J Gastroenterol 1991; 26:661-666.
10. Green FW, Kaplan MM, Curtis LE, Levine PH: Effect of acid and pepsin on blood coagulation and platelet aggregation. Gastroenterol 1978; 74:38-43.
11. Low J, Dodds AJ, Biggs JC: Fibrinolytic activity of gastroduodenal secretions - a possible role in upper gastrointestinal haemorrhage. Thromb Res 1980; 17:819-830.
12. Patchett SE, Enright H, Afdhal N, O'Connell W, O'Donoghue DP: Clot lysis by gastric juice: an in vitro study. Gut 1989; 30:1704-1707.
13. Piper D, Fenton B: pH stability and activity curves of pepsin with special reference to their clinical importance. Gut 1965; 6:506-508.
14. Wilde MI, McTavish D: Omeprazole, an update of its pharmacology and therapeutic use in acid-related disorders. Drugs 1994; 48:91-132.
15. Labenz J, Peitz U, Leusing C, Tillenburg B, Blum AL, Borsch G: Efficacy of primed infusions with high dose ranitidine and omeprazole to maintain high intragastric pH in patients with peptic ulcer bleeding: a prospective randomised controlled study. Gut 1997; 40:36-41.
16. Kiilerich S, Rannem T, Elsborg L: Effect of intravenous infusion of omeprazole and ranitidine on twenty-four hour intragastric pH in patients with a history of duodenal ulcer. Digestion 1995; 56:25-30.
17. Lin HJ, Lo WC, Lee FY, Perng CL, Tseng GY: A prospective randomized comparative trial showing that omeprazole prevents rebleeding in patients with bleeding peptic ulcer after successful endoscopic therapy. Arch Intern Med 1998; 158:54-58.
18. Daneshmend TK, Hawkey CJ, Langman MJS, Logan RFA, Long RG, Walt RP: Omeprazole versus placebo for acute upper gastrointestinal bleeding: randomised double blind controlled trial. Gut 1992; 304:143-147.
19. Villanueva C, Balanzo, Torras X, Sainz S, Soriano G, Gonzalez D, Vilardell F: Omeprazole versus ranitidine as adjunct therapy to endoscopic injection in actively bleeding ulcers: a prospective and randomized study. Endoscopy 1995; 27:308-312.
20. Brunner GHG, Thiesemann C: The potential clinical role of intravenous omeprazole. Digestion 1992; 51(S1):17-20.
21. Lanas A, Artal A, Blas JM, Arroyo MT, Lopez-Zaborras J, Sainz R: Effect of parenteral omeprazole and ranitidine on gastric pH and the outcome of bleeding peptic ulcer. J Clin Gastroenterol 1995; 21:103-106.
22. Grosso C, Rossi A, Gambitta P, Bini M, Zanasi G, Pirone Z, Arcidiacono R: Non-bleeding visible vessel treatment: perendoscopic injection therapy versus omeprazole infusion. Scand J Gastroenterol 1995; 30:872-875.
23. Lin HJ, Perng CL, Lee FY, Lee CH, Lee SD: Clinical courses and predictors for rebleeding in patients with peptic ulcers and non-bleeding visible vessels: a prospective study. Gut 1994; 35:1389-1393.
24. Lin HJ, Perng CL, Wang K, Lee SD, Lee CH: Long-term results of heater probe thermocoagulation for patients with massive peptic ulcer bleeding: a prospective observation. Am J Gastroenterol 1995; 90:44-47.
25. Lin HJ, Wang K, Perng CL, Lee FY, Lee CH, Lee SD: Natural history of bleeding peptic ulcers with a tightly adherent blood clot: a prospective observation. Gastrointest Endosc 1996; 43:470-473.
26. Teyssen S, Chari ST, Scheid J, Singer MV: Effect of repeated boluses of intravenous omeprazole and primed infusions of ranitidine on 24-hour intragastric pH in healthy human subjects. Dig Dis Sci 1995; 40:247-255.
27. Cederberg C, Andersson T, Skanberg I: Omeprazole: Pharmacokinetics and metabolism in man. Scan J Gastroenterol 1989; 24(Suppl 166):33-42.
28. Walt RP, Reynolds JR, Langman MJS, Smart HL, Kitchingman G, Somerville KW, Hawkey CJ: Intravenous omeprazole rapidly raises intragastric pH. Gut 1985; 26:902-906.
29. Labenz J, Tillenburg B, Peitz U, Idstrom JP, Verdu EF, Stolte M, et al: Helicobacter pylori augments the pH-increasing effect of omeprazole in patients with duodenal ulcer. Gastroenterol 1996; 110:725-732.
30. Savarino V, Mela GS, Zentilin P, Cutela P, Mele MR, Vigneri D, Celle G: Variability in individual responses to various doses of omeprazole. Implications for antiulcer therapy. Dig Dis Sci 1994; 39:161-168.
31. Hasselgren G, Lind T, Lundell L, Aadland E, Efskind P, Falk A: Continuous intravenous infusion of omeprazole in elderly patients with peptic ulcer bleeding. Stand J Gastroenterol 1997; 32:328-333.
32. Mohamed SA, Fa MAAK: Omeprazole versus histamine H2 receptor antagonists in the treatment of acute upper nonvariceal bleeding. Endoscopy 1996; 43:863-865.
33. Daneshmend TK, Hawkey CJ, Langman MJS, Logan RFA, Long RG, Walt RP: Omeprazole versus placebo for acute upper gastrointestinal bleeding: randomised double blind controlled trial. BMJ 1992; 304:143-147.