Inability of encapsulated Klebsiella pneumoniae to assemble functional type 1 fimbriae on their surface

FEMS Microbiology Letters

Volumn 179, Issue 1, 1999, Pages 123-130

  Matatov, Robert ^a   Goldhar, Janina ^a   Skutelsky, Ehud ^a   Sechter, Ianku ^b   Perry, Rachel ^a   Podschun, Reiner ^c   Sahly, Hany ^c   Thankavel, Krishnan ^d   Abraham, Soman N ^d   Ofek, Itzhak ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b MINISTRY OF HEALTH   (Israel)

^c UNIVERSITY OF KIEL   (Germany)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Capsule; Differential expression; FimH adhesin; Klebsiella pneumoniae; Phase variation; Type 1 fimbria

Indexed keywords

ADHESIN;

ARTICLE; BACTERIAL MEMBRANE; BACTERIOPHAGE; FIMBRIA; HEMAGGLUTINATION; IMMUNOBLOTTING; KLEBSIELLA PNEUMONIAE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

BACTERIA (MICROORGANISMS); KLEBSIELLA PNEUMONIAE;

EID: 0032874679     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1097(99)00402-4     Document Type: Article

References (28)

1. Williams, P. and Tomas, J.M. (1990) The pathogenicity of Klebsiella pneumoniae. Rev. Med. Microbiol. 1, 196-204.
2. Sahly, H. and Podschun, R. (1997) Clinical, bacteriological, and serological aspects of Klebsiella infections and their spondylahrtropatic sequele. Clin. Diagn. Lab. Immunol. 4, 393-399.
3. Tarkkanen, A.M., Allen, B.L., Williams, P.H., Haahtela, M.K.K., Sitonen, A., Orskov, I. and Orskov, F. et al. (1992) Fimbriation capsulation, and iron-scavenging systems of Klebsiella strains associated with human urinary tract. Infect. Immun. 60, 1187-1192.
4. Podschun, R.N., Sievers, A., Fischer, A. and Ullman, U. (1993) Serotypes, hemagglutinins, siderephore synthesis, and resistance of Klebsiella isolates causing urinary tract infections. J. Infect. Dis. 68, 1415-1421.
5. Domenico, P., Salo, R.J., Cross, A.S. and Kahn, B.A. (1994) Polysaccharide capsule-mediated resistance to opsonophagocytosis in Klebsiella pneumoniae. Infect. Immun. 62, 4495-4499.
6. Ofek, I., Goldhar, J., Keisari, Y. and Sharon, N. (1995) Non-opsonic phagocytosis of microorganisms. Ann. Rev. Microbiol. 49, 239-276.
7. Klemm, P. and Krogfeld, K.A. (1994) Type 1 fimbriae of Escherichia coli. In: Fimbriae, Adhesion, Genetics, Biogenesis and Vaccins (Klemm, P., Ed.), pp. 9-26. CRC Press, Boca Raton, FL.
8. Ofek, I. and Doyle, R.J. (1994) Bacterial Adhesion to Cells and Tissues, pp. 239-377. Chapman and Hall, London.
9. Lim, J.K., Gunther IV, N.W., Zhao, H., Johnson, D.E., Keay, S.K. and Mobley, H.L.T. (1998) In vivo phase variation of Escherichia coli type 1 fimbrial genes in women with urinary tract infections. Infect. Immun. 66, 3303-3310.
10. Arakava, Y., Ohta, M., Wacharotayankun, R. and Mori, M. et al. (1991) Biosynthesis of Klebsiella K2 capsule polysaccharide in Escherichia coli HB101 requires the functions of and the chromosomal cps gene cluster of the virulent strain Klebsiella pneumoniae Chedid (O1:K2). Infect. Immun. 59, 2043-2050.
11. McCallum, K.I. and Witfield, C. (1991) The rcsA gene of O1:K20 is involved in expression of serotype-specific K (capsular) antigen. Infect. Immun. 59, 494-502.
12. Favre-Bonte, S., Joly, B. and Forestier, C. (1999) Consequences of reduction of Klebsiella pneumoniae capsule expression on interaction of this bacterium with epithelial cells. Infect. Immun. 67, 554-561.
13. Ofek, I., Kabha, K. and Athamna, A. et al. (1993) Genetic exchange of determinants for capsular polysaccharide biosynthesis between Klebsiella pneumoniae strains expressing serotypes K2 and K21a. Infect. Immun. 61, 4208-4216.
14. Goldhar, J. (1994) Bacterial lectinlike adhesins: Determination and specificity. Methods Enzymol. 236B, 211-231.
15. Domenico, P., Schwartz, S. and Cunha, B.A. (1989) Reduction of capsular polysaccharide production on Klebsiella pneumoniae by sodium salicylate. Infect. Immun. 57, 3778-3782.
16. Murray, P.R. (1995) Manual of Clinical Microbiology, pp. 103 and 1327-1341. A.S.M. Press, Washington, DC.
17. Maayan, M.C., Ofek, I., Medalia, O. and Aronson, M. (1985) Population shift in mannose-specific fimbriated phase of Klebsiella pneumoniae during experimental urinary tract infection in mice. Infect. Immun. 49, 785-789.
18. Wright, A.C., Powell, J.L., Tanner, M.K., Ensor, L.A., Karpas, A.B., Morris Jr., J.G. and Sztein, M.B. (1999) Differential expression of Vibrio vulnificus capsular polysaccharide. Infect. Immun. 67, 2250-2257.
19. Thankavel, K., Madison, B. and Ikeda, T. et al. (1997) Localization of a domain in the FimH adhesin of Escherichia coli type 1 fimbriae capable of receptor recognition and use of domain- specific antibody to confer protection against experimental urinary tract infection. J. Clin. Invest. 100, 1123-1136.
20. Blumenkrantz, N. and Asboe-Hansen, G. (1973) New method for quantitative determination of uronic acids. Anal. Biochem. 54, 484-489.
21. Sahly, H., Kekow, J., Podschun, R., Schaff, M., Gross, W.L. and Ullmann, U. (1994) Comparison of the antibody responses to the 77 Klebsiellacapsular types in ankylosing spondylitis and various rheumatic diseases. Infect. Immun. 62, 4838-4843.
22. Ames, G.F.L. (1994) Isolation and purification of periplasmic binding proteins. Methods Enzymol. 235, 234-241.
23. Bradford, M.M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
24. Krogfelt, K.A., Bergmans, H. and Klemm, P. (1990) Direct evidence that the FimH protein is the mannose-specific adhesin of Escherichia coli type 1 fimbriae. Infect. Immun. 58, 1995-1998.
25. Towbin, H., Stachelin, T. and Gordon, J. (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitro-cellulose sheets; procedures and applications. Proc. Natl. Acad. Sci. USA 76, 4350-4352.
26. Matatov, R., Sechter, I., Perry, R., Kabha, K., Sahly, H., Podschun, R., Ofek, I. and Goldhar, J. (1995) Expression of type 1 fimbriae and capsule in Klebsiella pneumoniae K21a. Adv. Exp. Med. Biol. 408, 275.
27. Tewari, R., MacGregor, J.I., Ikeda, T., Little, J.R., Hultgren, S.J. and Abraham, S.N. (1993) Neutrophil activation by nascent FimH subunits of type 1 fimbriae purified from periplasm of Escherichia coli. J. Biol. Chem. 268, 3009-3015.
28. Jones, C.H., Jacob-Dubuisson, F. and Dodson, K. et al. (1992) Adhesin presentation in bacteria requires molecular chaperones and ushers. Infect. Immun. 60, 4445-4451.