CYP1/2 activation and glutathione-dependent cytotoxicity of four pesticides in Hep G2 and Fa32 cells

Toxicology in Vitro

Volumn 13, Issue 4-5, 1999, Pages 779-783

  Dierickx, P J ^a  

^a Afdeling Toxikologie   (Belgium)

Author keywords

Benomyl; Carbaryl; Carbendazim; Cytochrome; Cytotoxicity; EROD; Fa32; glutathione; Hep G2; Hepatocytes; PROD; Quinalphos

Indexed keywords

BENOMYL; CARBARIL; CARBENDAZIM; GLUTATHIONE; PESTICIDE; QUINALPHOS;

ANIMAL CELL; CELL LINE; CELL STRAIN HEPG2; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; NONHUMAN; RAT;

EID: 0032872981     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-2333(99)00045-4     Document Type: Conference Paper

References (15)

1. Borenfreund E., Shopsis C. Toxicity monitored with a correlated set of cell-culture assays. Xenobiotica. 15:1985;705-711.
2. Brandao J.C., Bohets H.H.L., Van de Vyver I.E., Dierickx P.J. Correlation between the in vitro cytotoxicity to cultured fathead minnow fish cells and fish lethality data for 50 chemicals. Chemosphere. 25:1992;553-562.
3. de Sousa G., Fontaine F., Pralavorio M., Botta-Fridlund D., Letreut Y., Rahmani R. Insecticide cytotoxicity and CYP1A1/2 induction in primary human and rat hepatocyte cultures. Toxicology in Vitro. 11:1997;451-456.
4. Dierickx P.J. Inhibition of glutathione-dependent uridine uptake in cultured human hepatoma cells. Medical Science Research. 15:1987;1349-1350.
5. Dierickx P.J. The influence of glutathione on the cytotoxicity of metals in rat hepatoma-derived Fa32 cells. ATLA. 24:1996;399-403.
6. Dierickx P.J. Activation by sodium fluoride of drug-metabolizing enzymes in rat hepatoma-derived Fa32 cells. FEBS Letters. 422:1998;185-188.
7. Donato M.T., Gomez-Lechon M.J., Castell J.V. A microassay for measuring cytochrome P450IA1 and P450IIB1 activities in intact human and rat hepatocytes cultured on 96-well plates. Analytical Biochemistry. 213:1993;29-33.
8. Doostdar H., Duthie S.J., Burke M.D., Melvin W.T., Grant M.H. The influence of culture medium composition on drug metabolising enzyme activities of the human liver derived Hep G2 cell line. FEBS Letters. 241:1988;15-18.
9. Griffith O.W. Mechanisms of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis. Journal of Biological Chemistry. 257:1982;13704-13712.
10. Hodgson E., Philpot R.M. Interaction of methylenedioxyphenyl [1,3-benzodioxole] compounds with enzymes and their effects on mammals. Drug Metabolism Reviews. 3:1974;231-301.
11. Hodgson E., Ryu D-Y., Adams N., Levi P.E. Biphasic responses in synergistic interactions. Toxicology. 105:1995;211-216.
12. Mathews J.M., Bend J.R. N-Alkylaminobenzotriazoles as enzyme-selective suicide inhibitors of rabbit pulmonoary microsomal cytochrome P-450. Molecular Pharmacology. 30:1986;25-32.
13. Nakama A., Kuroda K., Yamada A. Induction of cytochrome P450-dependent monooxygenase in serum-free cultured Hep G2 cells. Biochemical Pharmacology. 50:1995;1407-1412.
14. Radice S., Marabini L., Cipelletti B., Chiesara E. Effects of benomyl on cytochrome P450 monooxygenase systems in the Hep G2 cell line. ATLA. 24:1996;589-595.
15. Radice S., Marabini L., Gervasoni M., Ferraris M., Chiesara E. Carbendazim and n-butylisocyanate : metabolites responsible for benomyl double action on cytochrome P450 in Hep G2 cells. Toxicology. 123:1997;135-142.