Mucin-type O-glycans and leukosialin

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1455, Issue 2-3, 1999, Pages 205-217

  Fukuda, Minoru ^a   Tsuboi, Shigeru ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

Cell adhesion; Core 2 branch; Core 2 branching 1,6 N acetylglucosaminyltransferase; Mucin type O glycan

Indexed keywords

GLYCAN; LEUKOSIALIN; MUCIN; N ACETYLGLUCOSAMINYLTRANSFERASE; OLIGOSACCHARIDE;

ANIMAL MODEL; CELL ADHESION; CHEMICAL STRUCTURE; HUMAN; HYPOTHESIS; IMMUNE DEFICIENCY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; THYMOCYTE; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD43; CARBOHYDRATE SEQUENCE; CELL ADHESION; CELL LINE; DNA, COMPLEMENTARY; HUMANS; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; MUCINS; N-ACETYLGLUCOSAMINYLTRANSFERASES; OLIGOSACCHARIDES; SIALOGLYCOPROTEINS; T-LYMPHOCYTES; THYMUS GLAND; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL; WISKOTT-ALDRICH SYNDROME;

MUS MUSCULUS;

EID: 0032872724     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4439(99)00067-8     Document Type: Review

References (87)

1. M. Fukuda, Cell surface carbohydrates: cell-type specific expression, in: M. Fukuda, O. Hindsgaul (Eds.), Molecular Glycobiology, Oxford University Press, Oxford, 1994, pp. 1-52.
2. Fukuda M. Leukosialin, a major O-glycan-containing sialoglycoprotein defining leukocyte differentiation and malignancy. Glycobiology. 1:1991;347-356.
3. H. Schachter, I. Brockhausen, The biosynthesis of serine (threonine)-N-acetylgalactosamine-linked carbohydrate moieties, in: H.J. Allen, E.C. Kisailus (Eds.), Glycoconjugates: Composition, Structure and Function, Marcel Dekker, New York, 1992, pp. 263-332.
4. Strous G.J., Dekker J. Mucin type glycoproteins. Crit. Rev. Biochem. Mol. Biol. 27:1992;57-92.
5. Hounsell E.F., Davies M.J., Renouf D.V. O-Linked protein glycosylation structure and function. Glycoconjugate J. 13:1996;19-26.
6. Brown W.R., Barclay A.N., Sunderland C.A., Williams A.F. Identification of a glycophorin-like molecule at the cell surface of rat thymocytes. Nature. 289:1981;456-460.
7. Tomita M., Furthmayr H., Marchesi V.T. Primary structure of human erythrocyte glycophorin A. Isolation and characterization of peptides and complete amino acid sequence. Biochemistry. 17:1978;4756-4770.
8. Fukuda M. K562 human leukemic cells express fetal type (i) antigen on different glycoproteins from circulating erythrocytes. Nature. 285:1980;405-407.
9. Fukuda M., Fukuda M.N., Papanannopoulou T., Hakomori S. Membrane differentiation in human erythroid cells. Unique profiles of cell surface glycoproteins expressed in erythroblasts in vitro from three oncogenic stages. Proc. Natl. Acad. Sci. USA. 77:1980;3474-3478.
10. Anderson L.C., Gahmberg C.D. Surface glycoproteins of human white blood cells. Analysis by surface labeling. Blood. 52:1978;57-67.
11. M. Fukuda, M.N. Fukuda, Cell surface glycoproteins and carbohydrate antigens in development and differentiation of human erythroid cells, in: R.J. Ivatt (Ed.), The Biology of Glycoproteins. Plenum, New York, 1984, pp. 183-234.
12. Carlsson S.R., Fukuda M. Isolation and characterization of leukosialin, a major sialoglycoprotein on human leukocytes. J. Biol. Chem. 261:1986;12779-12786.
13. Remold-O'Donnel E., Kenney D.M., Parkman R., Cirna L., Savage B., Rosen F.S. Characterization of the human lymphocyte surface sialoglycoprotein that is defective in Wiskott-Aldrich syndrome. J. Exp. Med. 159:1984;1705-1723.
14. Segrest J.P., Jackson R.L., Andrews E.P., Marchesi V.T. Human erythrocyte membrane glycoprotein: a re-evaluation of the molecular weight as determined by SDS polyacrylamide gel electrophoresis. Biochem. Biophys. Res. Commun. 44:1971;390-396.
15. Killeen N., Barclay A.N., Willis A.C., Williams A.F. The sequence of rat leukosialin (W3/13 antigen) reveals a molecule with O-linked glycosylation of one third of its extracellular amino acids. EMBO J. 6:1987;4029-4034.
16. Pallant A., Eskenazi A., Mattei M.-G., Fournier R.E.K., Carlsson S.R., Fukuda M., Frelinger J.G. Identification of cDNAs encoding human leukosialin and localization of the leukosialin gene to chromosome 16. Proc. Natl. Acad. Sci. USA. 86:1989;1328-1332.
17. Shelley C.S., Remold O.D.E., Davis A.E.D., Bruns G.A., Rosen F.S., Carroll M.C., Whitehead A.S. Molecular characterization of sialophorin (CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome [published erratum appears in Proc. Natl. Acad. Sci. USA 1989 Jun; 86(12):4689]. Proc. Natl. Acad. Sci. USA. 86:1989;2819-2823.
18. Cyster J.G., Shotton D.M., Williams A.F. The dimensions of the T lymphocyte glycoprotein leukosialin and identification of linear protein epitopes that can be modified by glycosylation. EMBO J. 10:1991;893-902.
19. Corbi A.L., Larson R.S., Kishimoto T.K., Springer T.A., Morton C.C. Chromosomal location of the genes encoding the leukocyte adhesion receptors LFA-1, Mac-1 and p150,95. Identification of a gene cluster involved in cell adhesion. J. Exp. Med. 167:1988;1597-1607.
20. Ehlich A., Schaal S., Gu H., Kitamura D., Muller W., Rajewsky K. Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development. Cell. 72:1993;695-704.
21. Dragone L.L., Barth R.K., Sitar K.L., Disbrow G.L., Frelinger J.G. Disregulation of leukosialin (CD43, Ly48, sialophorin) expression in the B-cell lineage of transgenic mice increases splenic B-cell number and survival. Proc. Natl. Acad. Sci. USA. 92:1995;626-630.
22. Kudo S., Fukuda M. A short, novel promoter sequence confers the expression of human leukosialin, a major sialoglycoprotein on leukocytes. J. Biol. Chem. 266:1991;8483-8489.
23. Kudo S., Fukuda M. Transcriptional activation of human leukosialin (CD43) gene by Sp1 through binding to a GGGTGG motif. Eur. J. Biochem. 223:1994;319-327.
24. Kudo S., Fukuda M. Tissue-specific transcriptional regulation of human leukosialin (CD43) gene is achieved by DNA methylation. J. Biol. Chem. 270:1995;13298-13302.
25. Kudo S. Methyl-CpG-binding protein MeCP2 represses Sp1-activated transcription of the human leukosialin gene when the promoter is methylated. Mol. Cell. Biol. 18:1998;5492-5499.
26. Carlsson S.R., Sasaki H., Fukuda M. Structural variations of O-linked oligosaccharides present in leukosialin isolated from erythroid, myeloid and T-lymphoid cell lines. J. Biol. Chem. 261:1986;12787-12795.
27. Piller F., Piller V., Fox R.I., Fukuda M. Human T-lymphocyte activation is associated with changes in O-glycan biosynthesis. J. Biol. Chem. 263:1988;15146-15150.
28. Saitoh O., Piller F., Fox R.I., Fukuda M. T-Lymphocytic leukemia express complex, branched O-linked oligosaccharides on a major sialoglycoprotein, leukosialin. Blood. 77:1991;1491-1499.
29. Brown W.R., Williams A.F. Lymphocyte cell surface glycoproteins which bind to soybean and peanut lectins. Immunology. 46:1982;713-726.
30. N. Sharon, in: M. Fougereau, J. Dausset (Eds.), Progress in Immunology IV, vol. III, Academic Press, London, 1980, p. 254.
31. Gillespie W., Paulson J.C., Kelm S., Pang M., Baum L.G. Regulation of alpha2,3-sialyltransferase expression correlates with conversion of peanut agglutinin (PNA)+ to PNA- phenotype in developing thymocytes. J. Biol. Chem. 268:1993;3801-3804.
32. Sportsman J.R., Park M.M., Cheresh D.A., Fukuda M., Elder J.H., Fox R.I. Characterization of a membrane surface glycoprotein associated with T-cell activation. J. Immunol. 135:1985;158-164.
33. Piller F., Le Deist F., Weinberg K., Parkman R., Fukuda M. Altered O-glycan synthesis in lymphocytes from patients with Wiskott-Aldrich syndrome. J. Exp. Med. 173:1991;1501-1510.
34. Bierhuizen M.F., Maemura K., Fukuda M. Expression of a differentiation antigen and poly-N-acetyllactosaminyl O-glycans directed by a cloned core 2 β-1,6-N-acetylglucosaminyltransferase. J. Biol. Chem. 269:1994;4473-4479.
35. Baum L.G., Pang M., Perillo N.L., Wu T., Delegeane A., Uittenbogaart C.H., Fukuda M., Seilhamer J.J. Human thymic epithelial cells express an endogenous lectin, galectin-1, which binds to core 2 O-glycans on thymocytes and T lymphoblastoid cells. J. Exp. Med. 181:1995;877-887.
36. Bierhuizen M.F., Fukuda M. Expression cloning of a cDNA encoding UDP-GlcNAc:Gal β 1-3-GalNAc-R (GlcNAc to GalNAc) beta 1-6GlcNAc transferase by gene transfer into CHO cells expressing polyoma large tumor antigen. Proc. Natl. Acad. Sci. USA. 89:1992;9326-9330.
37. Patel D.D., Haynes B.F. Cell adhesion molecules involved in intrathymic T cell development. Semin. Immunol. 5:1993;282-292.
38. Perillo N.L., Pace K.E., Seilhamer J.J., Baum L.G. Apoptosis of T cells mediated by galectin-1. Nature. 378:1995;736-739.
39. Park J.K., Rosenstein Y.J., Remold-O'Donnell E., Bierer B.E., Rosen F.S., Burakoff S.J. Enhancement of T-cell activation by the CD43 molecule whose expression is defective in Wiskott-Aldrich syndrome. Nature. 350:1991;706-710.
40. Ardman B., Sikorski M.A., Staunton D.E. CD43 interferes with T-lymphocyte adhesion. Proc. Natl. Acad. Sci. USA. 89:1992;5001-5005.
41. Yonemura S., Nagafuchi A., Sato N., Tsukita S. Concentration of an integral membrane protein, CD43 (leukosialin, sialophorin), in the cleavage furrow through the interaction of its cytoplasmic domain with actin-based cytoskeletons. J. Cell Biol. 120:1993;437-449.
42. Schmid K., Hediger M.A., Brossmer R., Collins J.H., Haupt H., Marti T., Offner G.D., Schaller J., Takagaki K., Walsh M.T., Schwick H.G., Rosen R.S., Remold-O'Donnell E. Amino acid sequence of human plasma galactoglycoprotein: identity with the extracellular region of CD43 (sialophorin). Proc. Natl. Acad. Sci. USA. 89:1992;663-667.
43. Fukuda M., Carlsson S.R., Klock J.C., Dell A. Structures of O-linked oligosaccharides isolated from normal granulocytes, chronic myelogenous leukemia cells and acute myelogenous leukemia cells. J. Biol. Chem. 261:1986;12796-12806.
44. Nathan C., Xie Q.W., Halbwachs-Mecarelli L., Jin W.W. Albumin inhibits neutrophil spreading and hydrogen peroxide release by blocking the shedding of CD43 (sialophorin, leukosialin). J. Cell Biol. 122:1993;243-256.
45. Bazil V., Strominger J.L. CD43, the major sialoglycoprotein of human leukocytes, is proteolytically cleaved from the surface of stimulated lymphocytes and granulocytes. Proc. Natl. Acad. Sci. USA. 90:1993;3792-3796.
46. Maemura K., Fukuda M. Poly-N-acetyllactosaminyl O-glycans attached to leukosialin. The presence of sialyl Le(x) structures in O-glycans. J. Biol. Chem. 267:1992;24379-24386.
47. Ohmori K., Takada A., Yoneda T., Buma Y., Hirashima K., Tsuyuoka K., Hasegawa A., Kannagi R. Differentiation-dependent expression of sialyl stage-specific embryonic antigen-1 and I-antigens on human lymphoid cells and its implications for carbohydrate-mediated adhesion to vascular endothelium. Blood. 81:1993;101-111.
48. Springer T.A. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell. 76:1994;301-314.
49. J.B. Lowe, Carbohydrate recognition in cell-cell interaction, in: M. Fukuda, O. Hindsgaul (Eds.), Molecular Glycobiology, Oxford University Press, Oxford, 1984, pp. 163-194.
50. Rosen S.D., Bertozzi C.R. Two selectins converge on sulphate. Leukocyte adhesion. Curr. Biol. 6:1996;261-264.
51. Wilkins P.P., McEver R.P., Cummings R.D. Structures of the O-glycans on P-selectin glycoprotein ligand-1 from HL-60 cells. J. Biol. Chem. 271:1996;18732-18742.
52. Ellies L.G., Tsuboi S., Petryniak B., Lowe J.B., Fukuda M., Marth J.D. Core 2 oligosaccharide biosynthesis distinguishes between selectin ligands essential for leukocyte homing and inflammation. Immunity. 9:1998;881-890.
53. Sako D., Chang X.J., Barone K.M., Vachino G., White H.M., Shaw G., Veldman G.M., Bean K.M., Ahern T.J., Furie B., Cumming D.A., Larsen G.R. Expression cloning of a functional glycoprotein ligand for P-selectin. Cell. 75:1993;1179-1186.
54. Sako D., Comess K.M., Barone K.M., Camphausen R.T., Cumming D.A., Shaw G.D. A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding. Cell. 83:1995;323-331.
55. Pouyani T., Seed B. PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus. Cell. 83:1995;333-343.
56. Lenter M., Levinovitz A., Isenmann S., Vestweber D. Monospecific and common glycoprotein ligands for E- and P-selectin on myeloid cells. J. Cell Biol. 125:1994;471-481.
57. Asa D., Raycroft L., MA L., Aeed P.A., Kaytes P.S., Elhammer A.P., Geng J.G. The P-selectin glycoprotein ligand functions as a common human leukocyte ligand for P- and E-selectin. J. Biol. Chem. 270:1995;11662-11670.
58. Steegmaier M., Levinovitz A., Isenmann S., Borges E., Lenter M., Kocher H.P., Kleuser B., Vestweber D. The E-selectin-ligand ESL-1 is a variant of a receptor for fibroblast growth factor. Nature. 373:1995;615-620.
59. Lawrence M.B., Springer T.A. Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins. Cell. 65:1991;859-873.
60. Ley K., Gaehtgens P., Fennie C., Singer M.S., Lasky L.A., Rosen S.D. Lectin-like cell adhesion molecule 1 mediates leukocyte rolling in mesenteric venules in vivo. Blood. 77:1991;2553-2555.
61. Mulligan M.S., Lowe J.B., Larsen R.D., Paulson J., Zheng Z.L., DeFrees S., Maemura K., Fukuda M., Ward P.A. Protective effects of sialylated oligosaccharides in immune complex-induced acute lung injury. J. Exp. Med. 178:1993;623-631.
62. Sawada R., Tsuboi S., Fukuda M. Differential E-selectin-dependent adhesion efficiency in sublines of a human colon cancer exhibiting distinct metastatic potentials. J. Biol. Chem. 269:1994;1425-1431.
63. x as a new tumor-associated antigen. Cancer Res. 44:1984;5279-5285.
64. Magnani J.L., Nilsson B., Brockhaus M., Zopf D., Steplewski Z., Koprowski H., Ginsburg V. A monoclonal antibody-defined antigen associated with gastrointestinal cancer is a ganglioside containing sialylated lacto-N-fucopentaose II. J. Biol. Chem. 257:1982;14365-14369.
65. x antigen correlates with poor survival in patients with colorectal carcinoma: clinicopathological and immunohistochemical study. Cancer Res. 53:1993;3632-3637.
66. Brockhausen I., Kuhns W., Schachter H., Matta K.L., Sutherland D.R., Baker M.A. Biosynthesis of O-glycans in leukocytes from normal donors and from patients with leukemia: increase in O-glycan core 2 UDP-GlcNAc:Galβ3GalNAcα-R (GlcNAc to GalNAc)β(1-6)-N-acetylglucosaminyltransferase in leukemic cells. Cancer Res. 51:1991;1257-1263.
67. Berg E.L., Robinson M.K., Mansson O., Butcher E.C., Magnani J.L. A carbohydrate domain common to both sialyl Le(a) and sialyl Le(X) is recognized by the endothelial cell leukocyte adhesion molecule ELAM-1. J. Biol. Chem. 266:1991;14869-14872.
68. Nicolson G.L. Metastatic tumor cell interactions with endothelium, basement membrane and tissue. Curr. Opin. Cell Biol. 1:1989;1009-1019.
69. Shimodaira K., Nakayama J., Nakamura N., Hasebe O., Katsuyama T., Fukuda M. Carcinoma-associated expression of core 2 β-1,6-N-acetylglucosaminyltransferase gene in human colorectal cancer: role of O-glycans in tumor progression. Cancer Res. 57:1997;5201-5206.
70. Ohyama C., Tsuboi S., Fukuda M. Dual roles of sialyl Lewis X oligosaccharides in tumor metastasis and rejection by NK cells. EMBO J. 18:1999;1516-1525.
71. Piller F., Le Deist F., Weinberg K.I., Parkman R., Fukuda M. Altered O-glycan synthesis in lymphocytes from patients with Wiskott-Aldrich syndrome. J. Exp. Med. 173:1991;1501-1510.
72. Higgins E.A., Siminovitch K.A., Zhuang D.L., Brockhausen I., Dennis J.W. Aberrant O-linked oligosaccharide biosynthesis in lymphocytes and platelets from patients with the Wiskott-Aldrich syndrome. J. Biol. Chem. 266:1991;6280-6290.
73. Giordanengo V., Fuziber J.G., Fox R., Fukuda M., Lefebvre J.C. Inverse proportions of activated and CD4+ circulating lymphocytes in AIDS patients. AIDS. 13:1999;1441-1442.
74. Ardman B., Sikorski M.A., Settles M., Staunton D.E. Human immunodeficiency virus type 1-infected individuals make autoantibodies that bind to CD43 on normal thymic lymphocytes. J. Exp. Med. 172:1990;1151-1158.
75. Lefebvre J.-C., Giordanengo V., Limouse M., Doglio A., Cucchiarini M., Monpoux F., Mariani R., Peyron J.-F. Altered glycosylation of leukosialin, CD43, in HIV-1-infected cells of the CEM line. J. Exp. Med. 180:1994;1609-1617.
76. J.M.J. Derry, H.D. Ochs, U. Francke, Isolation of a novel gene mutated in Wiskott-Aldrich syndrome, Cell 78 (1994) 635-644 (erratum Cell 79, 1994).
77. J.M.J. Derry, H.D. Ochs, U. Francke, Isolation of a novel gene mutated in Wiskott-Aldrich syndrome, Cell 78 (1994) 635-644 (erratum Cell 79, 1994).
78. Tsuboi S., Fukuda M. Branched O-linked oligosaccharides aberrantly expressed in the Wiskott-Aldrich syndrome reduce primary T-cell immune responses. EMBO J. 16:1997;6364-6373.
79. Tsuboi S., Fukuda M. Overexpression of branched O-linked oligosaccharides on T cell surface glycoproteins impairs humoral immune responses in transgenic mice. J. Biol. Chem. 273:1998;30680-30687.
80. Manjunath N., Correa M., Ardman M., Ardman B. Negative regulation of T-cell adhesion and activation by CD43. Nature. 377:1995;535-538.
81. Komatsu M., Carraway C.A., Fregien N.L., Carraway K.L. Reversible disruption of cell-matrix and cell-cell interactions by overexpression of sialomucin complex. J. Biol. Chem. 272:1997;33245-33254.
82. Hemmerich S., Leffler H., Rosen S.D. Structure of the O-glycans in GlyCAM-1, an endothelial-derived ligand for L-selectin. J. Biol. Chem. 270:1995;12035-12047.
83. Yeh J.-C., Ong E., Fukuda M. Molecular cloning and expression of a novel β-1,6-N-acetylglucosaminyltransferase that forms core 2, core 4, and I branches. J. Biol. Chem. 274:1999;3215-3221.
84. Lowe J.B., Stoolman L.M., Nair R.P., Larsen R.D., Berhend T.L., Marks R.M. ELAM-1-dependent cell adhesion to vascular endothelium determined by a transfected human fucosyltransferase cDNA. Cell. 63:1990;475-484.
85. Siebert P.D., Fukuda M. Isolation and characterization of human glycophorin A cDNA clones using a synthetic oligonucleotide approach: nucleotide sequence and mRNA structure. Proc. Natl. Acad. Sci. USA. 83:1986;1665-1669.
86. Piller V., Piller F., Klier F.G., Fukuda M. O-Glycosylation of leukosialin in K562 cells: evidence for initiation and elongation in early Golgi compartments. Eur. J. Biochem. 183:1989;123-135.
87. Ujita M., McAuliffe J., Schwientek T., Almeida R., Hindsgaul O., Clausen H., Fukuda M. Synthesis of poly-N-acetyllactosamine in core 2 branched O-glycans. J. Biol. Chem. 273:1998;34843-34849.