Molecular biological aspects of inhibitor development

Vox Sanguinis

Volumn 77, Issue SUPPL. 1, 1999, Pages 13-16

  Tuddenham, E G D ^a  

^a MRC CLINICAL SCIENCES CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 8 INHIBITOR; RECOMBINANT BLOOD CLOTTING FACTOR 8;

CONFERENCE PAPER; GENE DELETION; GENE MAPPING; GENE MUTATION; GENOTYPE; HEMOPHILIA; HUMAN; INTERNET; INTRAVENOUS DRUG ADMINISTRATION; MISSENSE MUTATION; MOLECULAR BIOLOGY; PRIORITY JOURNAL; STOP CODON; STRUCTURE ACTIVITY RELATION;

DATABASES, FACTUAL; EPITOPES; FACTOR VIII; GENOTYPE; HEMORRHAGIC DISORDERS; HUMANS; IMMUNE TOLERANCE; ISOANTIBODIES; MODELS, MOLECULAR; MUTATION, MISSENSE; PHENOTYPE; PROTEIN STRUCTURE, TERTIARY;

EID: 0032872459     PISSN: 00429007     EISSN: None     Source Type: Journal    
DOI: 10.1159/000056707     Document Type: Conference Paper

References (4)

1. Pemberton S, Lindley P, Zaitsev V, Card G, Tuddenham EGD, Kemball-Cook G: A molecular model for the triplicated A domains of human factor VIII based on the crystal structure of human ceruloplasmin. Blood 1997;89: 2413-2421.
2. Villoutreix BO, Bucher P, Hofmann K, Baumgartner S, Dahlback B: Molecular models for the two discoidin domains of human blood coagulation factor V. J Molec Modelling 1998;4:1-7.
3. Tagliavacca L, Moon N, Dunham WR, Kaufman RJ: Identification and functional requirement of Cu(I) and its ligands within coagulation factor VIII. J Biol Chem 1997;272:27428-27434.
4. Brandstetten H, Bauer M, Huber R, Lollan P, Bode W: X-ray structure of cloning factor IXa: Active site and module structure related to Xase activity and hemophilia B. Proc Nat Acad Sci (USA) 1995;92:9796-9800.