Effect of wood creosote and loperamide on propulsive motility of mouse colon and small intestine

Pharmacology

Volumn 59, Issue 4, 1999, Pages 212-220

  Ogata, Norio ^a,b   Ataka, Koji ^a   Morino, Hirofumi ^a   Shibata, Takashi ^a  

^a Taiko Pharmaceutical Company Ltd   (Japan)

^b Taiko Pharmaceutical Co Ltd   (Japan)

Author keywords

4 Ethylguaiacol; Charcoal meal test; Colon; Diarrhea; Glass bead test; Guaiacol; Intestine, mouse; Loperamide; Propulsive motility; Wood creosote

Indexed keywords

ANTIDIARRHEAL AGENT; CHARCOAL; CREOSOTE; LOPERAMIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COLON MOTILITY; CONTROLLED STUDY; DRUG MECHANISM; INTESTINE MOTILITY; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; TEST MEAL;

ANIMALS; ANTIDIARRHEALS; ANTIDOTES; CHARCOAL; COLON; CREOSOTE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GASTROINTESTINAL MOTILITY; INTESTINE, SMALL; LOPERAMIDE; MALE; MICE; TIME FACTORS;

EID: 0032872386     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000028322     Document Type: Article

References (21)

1. Ogata N, Baba T: Analysis of beechwood creosote by gas chromatography-mass spectrometry and high-performance liquid chromatography. Res Commun Chem Pathol Pharmacol 1989;66:411-423.
2. Haller JS Jr: Creosote: A short history of its medicinal uses. Conn Med 1990;54:502-507.
3. Ogata N, Baba T, Shibata T: Demonstration of antidiarrheal and anti-motility effects of wood creosote. Pharmacology 1993;46:173-180.
4. Toyoda M, Ogata N, Shibata T: Suppression of intestinal smooth muscle contraction by 4-ethylguaiacol, a constituent of wood creosote. Pharmacology 1993;47:300-308.
5. Ogata N, Toyoda M, Shibata T: Suppression of intestinal smooth muscle contraction by phenolic comounds. Res Commun Chem Pathol Pharmacol 1992;77:359-366.
6. Ataka K, Ogata N, Kuge T, Shibata T: Suppression of enterotoxin-induced intestinal fluid secretion by wood creosote. Res Commun Mol Pathol Pharmacol 1996;93:219-224.
7. Ogata N, Matsushima N, Shibata T: Pharmacokinetics of wood creosote: Glucuronic acid and sulfate conjugation of phenolic compounds. Pharmacology 1995;51:195-204.
8. Green AF: Comparative effects of analgesics on pain threshold, respiratory frequency and gastrointestinal propulsion. Br J Pharmacol 1959;14:26-34.
9. Koslo RJ, Burks TF, Porreca F: Centrally administered bombesin affects gastrointestinal transit and co-Ionic bead expulsion through supraspinal mechanisms. J Pharmacol Exp Ther 1986;238:62-67.
10. Yamada K, Onoda Y: Comparison of the effects of T-1815, yohimbine and naloxone on mouse colonic propulsion. J Smooth Muscle Res 1993; 29:47-53.
11. Jacoby HI, Lopez I: A method for the evaluation of colonic propulsive motility in the mouse after ICV administered compounds. Dig Dis Sci 1984;29:551.
12. Raffa RB, Mathiasen JR, Jacoby HI: Colonie bead expulsion time in normal and mu-opioid receptor deficient (CXBK) mice following central (ICV) administration of muand delta-opioid agonists. Life Sci 1987;41:2229-2234.
13. Sohji Y, Kawashima K, Shimizu M: Pharmacological studies of loperamide, an anti-diarrheal agent. II. Effects on peristalsis of the small intestine and colon in guinea pigs. Nippon Yakurigaku Zasshi 1978;74: 155-163.
14. Mellstrand T: Loperamide - an opiate receptor agonist with gastrointestinal motility effects. Scand J Gastroenterol 1987;22:65-66.
15. Rubinoff MJ, Piccione PR, Holt PR: Clonidine prolongs human small intestine transit time: Use of the lactulose-breath hydrogen test. Am J Gastroenterol 1989;84:372-374.
16. Garry RC: The responses to stimulation of the caudal end of the large bowel in the cat. J Physiol 1933;78: 208-224.
17. De Groat WC, Krier J: The sacral parasympathetic reflex pathway regulating colonic motility and defecation in the cat. J Physiol 1978;276: 481-500.
18. Rostad H: Colonic motility in the cat. II. Extrinsic nervous control. Acta Physiol Scand 1973;89:91-103.
19. 3H]loperamide binding to opioid receptors in rat and human small intestine. Int Narc Res 1990; 89:165-169.
20. De Luca A, Coupar IM: Insights into opioid action in the intestinal tract. Pharmacol Ther 1996;69:103-115.
21. Chamouard P, Rohr S, Meyer C, Baumann R, Angel F: δ-Opioid receptor agonists inhibit neuromuscular transmission in human colon. Eur J Pharmacol 1994;262:33-39.