Growth hormone treatment increases CO2 response, ventilation and central inspiratory drive in children with Prader-Willi syndrome

European Journal of Pediatrics

Volumn 158, Issue 11, 1999, Pages 936-940

  Lindgren, A C ^a   Hellstrom L G ^a   Ritzen E M ^a   Milerad, J ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

CO2; Growth hormone; Hypoventilation; Prader Willi syndrome; Ventilation

Indexed keywords

CARBON DIOXIDE; HUMAN GROWTH HORMONE; RECOMBINANT GROWTH HORMONE;

ADOLESCENT; AIRWAY OBSTRUCTION; AIRWAY PRESSURE; ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; LUNG VENTILATION; MALE; PRADER WILLI SYNDROME; PRIORITY JOURNAL; RESPIRATION CONTROL; SUBCUTANEOUS DRUG ADMINISTRATION;

ADOLESCENT; BODY MASS INDEX; CARBON DIOXIDE; CHILD; FEMALE; HUMAN GROWTH HORMONE; HUMANS; INJECTIONS, SUBCUTANEOUS; INSULIN-LIKE GROWTH FACTOR I; LINEAR MODELS; MALE; PRADER-WILLI SYNDROME; PULMONARY GAS EXCHANGE; PULMONARY VENTILATION; REFERENCE VALUES; TREATMENT OUTCOME;

EID: 0032871118     PISSN: 03406199     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004310051246     Document Type: Article

References (22)

1. Arens R, Gozal D, Omlin KJ, et al (1994) Hypoxic and hypercapnic ventilatory responses in Prader-Willi syndrome. J Appl Physiol 77:2224-2230
2. Burton KA, Kabigting EB, Clifton DK, Steiner RA (1992) Growth hormone receptor messenger ribonucleic acid distribution in the adult male rat brain and its co-localization in hypothalamic somatostatin neurons. Endocrinology 130:958-963
3. Cadieux RJ, Kales A, Santen RJ, Bixler EO, Gordon R (1982) Endoscopic findings in sleep apnea associated with acromegaly. J Clin Endocrinol Metab 55:18-22
4. Cassidy SB, Mckillop JA, Morgan WJ (1990) Sleep disorders in Prader-Willi syndrome. Dysmorphol Clin Genet 4:13-17
5. Dejours P (1976). Arterial chemoreceptors and ventilatory chemoreflexes in vertebrates. In: Duron B (ed) Respiratory centres and afferent systems. INSERM, Paris, WL 310 R434
6. Gozal D, Arens R, Omlin KJ, Ward SL, Keens TG (1994) Absent peripheral chemosensitivity in Prader-Willi syndrome. J Appl Physiol 77:2231-2236
7. Grunstein RR, Ho KY, Berthon-Jones M, Stewart D, Sullivan CE (1994) Central sleep apnea is associated with increased ventilatory response to carbon dioxide and hypersecretion of growth hormone in patients with acromegaly. Am J Respir Crit Care Med 150:496-502
8. Hertz G, Cataletto M, Feinsilver SH, Angulo M (1993) Sleep and breathing pattern in patients with Prader-Willi syndrome: effects of age and gender. Sleep 16:366-371
9. Holm VA, Cassidy SB, Butler MG, Hanchett JM, Greenswag LR, Whitman BY, Greenberg F (1993) Prader-Willi syndrome: consensus diagnostic criteria. Pediatrics 91:398-440
10. Horsthemke B (1997) Structure and function of the human chromosome 15 imprinting center. J Cell Physiol 173:237-241
11. 2 on ventilation. In: Fitzgerald RS, Gautier H, Lahiri S (eds) The regulation of respiration during sleep and anesthesia. Pergamon Press, New York, pp 403-414
12. Kaplan J, Fredrickson PA, Richardson JW (1991) Sleep and breathing in patients with Prader-Willi syndrome. Mayo Clin Proc 66:1124-1126
13. Lai ZN, Emtner M, Roos P, Nyberg F (1995) Characterization of putative growth hormone receptors in human choroid plexus. Brain Res 546:222-226
14. Larsson H, Hellstrom LG, Linnarsson D (1993) Breath-by-breath determination of inspiratory occlusion pressure. Clin Physiol 13:133-142
15. Lindgren AC, Hagenas L, Müller J, Blichfeldt S, Rosenborg M, Brismar T, Ritzén EM (1997) Effects of growth hormone treatment on growth and body composition in Prader-Willi syndrome: a preliminary report. Acta Pediatr Suppl 423:60-62
16. Lindgren AC, Hagenas L, Müller J, Blichfeldt S, Rosenborg M, Brismar T, Ritzén EM (1998) Growth hormone treatment of children with Prader-Willi syndrome affects linear growth and body composition favourably. Acta Pediatr 87:28-31
17. Livingston FR, Arens R, Bailey SL, Keens TG, Ward SL (1995) Hypercapnic arousal responses in Prader-Willi syndrome. Chest 108:1627-1631
18. McCormick D.A, Bal T (1997) Sleep and arousal: thalamocortical mechanisms. Ann Rev Neurosci 20:185-215
19. Milerad J, Lagercrantz H, Löfgren O (1985) Alveolar hypoventilation treated with medroxyprogesterone. Arch Dis Child 60:150-155
20. Turino GM, Goldring RM (1976) Techniques for measuring the responsiveness of the ventilatory apparatus in man in disease. Chest 70:180-185
21. Weese-Mayer DE, Silvestri JM, Menzies LJ, Morrow-Kenny AS, Hunt CE, Hauptman SA (1992) Congenital central hypoventilation syndrome: diagnosis, management, and long-term outcome in thirty-two children. J Pediatr 120:381-387
22. Whitelaw WA, Derenne JP (1993) Airway occlusion pressure. J Appl Physiol 74:1475-1483