Elevated levels of endogenous adenosine alter metabolism and enhance reduction in contractile function during low-flow ischemia: Associated changes in expression of Ca2+-ATPase and phospholamban

Journal of Molecular and Cellular Cardiology

Volumn 31, Issue 10, 1999, Pages 1897-1911

  Sommerschild, Hilchen T ^a   Lunde, Per Kristian ^a   Deindl, Elisabeth ^b   Jynge, Per ^c   Ilebekk, Arnfinn ^a   Kirkebøen, Knut Arvid ^a,d  

^a UNIVERSITY OF OSLO   (Norway)

^b MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

^c Medical Technical Center   (Norway)

^d ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

Author keywords

Ca2+ ATPase; Contractile function; Endogenous adenosine; Low flow ischemia; Metabolism; Phospholamban; Sarcoplasmic reticulum

Indexed keywords

ADENOSINE; ADENOSINE RECEPTOR BLOCKING AGENT; ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CALSEQUESTRIN; CARBON DIOXIDE; DRAFLAZINE; MESSENGER RNA; PHOSPHOLAMBAN; PROTON; RYANODINE RECEPTOR; SODIUM CALCIUM EXCHANGE PROTEIN; THEOPHYLLINE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART MUSCLE METABOLISM; HEART RATE; NONHUMAN; PRIORITY JOURNAL; SWINE;

EID: 0032869133     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.1999.1022     Document Type: Article

References (68)

1. Abraham S, Young RF, Canty Jr JM. Post-ischemic dysfunction following short-term hibernation is not associated with increased mRNA for sarcoplasmic reticulum calcium regulatory proteins (Abstract). Circulation. 94 (Suppl. I):1996;I-186.
2. Angello DA, Headrick JP, Coddington NH, Berne RM. Adenosine antagonism decreases metabolic but not functional recovery from ischemia. Am J Physiol. 260:1991;H193-200.
3. Arai AE, Grauer SE, Anselone CG, Pantely GA, Bristow JD. Metabolic adaptation to a gradual reduction in myocardial blood flow. Circulation. 92:1995;244-252.
4. Assayag P, Charlemagne D, Marty I, de Leiris J, Lompré AM, Boucher F, Valère P-E, Lortet S, Swynghedauw B, Besse S. Effects of sustained low-flow ischemia on myocardial function and calcium-regulating proteins in adult and senescent rat hearts. Cardiovasc Res. 38:1998;169-180.
5. Babitt DG, Virmani R, Forman MB. Intracoronary adenosine administered after reperfusion limits vascular injury after prolonged ischemia in the canine model. Circulation. 80:1989;1388-1399.
6. Baxter GF, Marber MS, Patel VC, Yellon DM. Adenosine receptor involvement in a delayed phase of myocardial protection 24 hours after ischemic preconditioning. Circulation. 90:1994;2993-3000.
7. Baxter GF, Yellon DM. Time course of delayed myocardial protection after transient adenosine A1-receptor activation in the rabbit. J Cardiovasc Pharmacol. 29:1997;631-638.
8. Baxter GF, Zaman MJS, Kerac M, Yellon DM. Protection against global ischemia in the rabbit isolated heart 24 hours after transient adenosine A1 receptor activation (Letter). Cardiovasc Drugs Ther. 11:1997;83-85.
9. Bolukoglu H, Goodwin GW, Guthrie PH, Carmical SG, Chen TM, Taegtmeyer H. Metabolic fate of glucose in reversible low-flow ischemia of the isolated working rat heart. Am J Physiol. 270:1996;H817-H826.
10. Camacho SA, Brandes R, Figueredo VM, Weiner MW. Ca2+ transient decline and myocardial relaxation are slowed during low-flow ischemia in rat hearts. J Clin Invest. 93:1994;951-957.
11. 87Rb NMR spectroscopic study. MRM. 34:1995;673-685.
12. Daly JW, Padgett W, Shamim MT, Butts-Lamb P, Waters J. 1,3-dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1 and A2-adenosine receptors. J Med Chem. 28:1985;487-492.
13. Dana A, Yamashita N, Baxter GF, Yellon DM. Involvement of protein kinases and manganese-superoxide dismutase in adenosine induced delayed preconditioning (Abstract). J Mol Cell Cardiol. 30 (abstract book):1998;A75.
14. Das DK, Maulik N, Moraru II. Gene expression in acute myocardial stress. Induction by hypoxia, ischemia, reperfusion, hyperthermia and oxidative stress (Review). J Mol Cell Cardiol. 27:1995;181-193.
15. Deindl E, Neubauer E, Elsasser A, Zimmermann R, Schaper W. Reduced contractile function characteristic for hibernating human heart is not mediated by phospholamban. Ann New York Acad Sci. 853:1998;270-272.
16. Delyani JA, van Wylen DGL. Endocardial and epicardial interstitial purines and lactate during graded ischemia. Am J Physiol. 266:1994;H1019-H1026.
17. Deng Q, Scicli AG, Lawton C, Silverman NA. Coronary flow reserve after ischemia and reperfusion of the isolated heart. Divergent results with crystalloid versus blood perfusion. J Thorac Cardiovasc Surg. 109:1995;466-472.
18. Downing SE, Chen V. Acute hibernation and reperfusion of the ischemic heart. Circulation. 85:1992;699-707.
19. Dyck JRB, Maddaford TG, Pierce GN, Fliegel L. Induction of expression of the sodium-hydrogen exchanger in rat myocardium. Cardiovasc Res. 29:1995;203-208.
20. Dørup I, Skajaa K, Clausen T. A simple and rapid method for the determination of the concentrations of magnesium, sodium, potassium and sodium, potassium pumps in human skeletal muscle. Clin Sci. 74:1988;241-248.
21. Eisenhauer CL, Matsuda LS, Uyehara CFT. Normal physiologic values of neonatal pigs and the effects of isoflurane and pentobarbital anesthesia. Lab Animal Science. 44:1994;245-252.
22. 2+-ATPase from sarcoplasmic reticulum in muscle biopsies. Biochem J. 260:1989;443-448.
23. Finegan BA, Lopaschuk GD, Coulson CS, Clanahan AS. Adenosine alters glucose use during ischemia and reperfusion in isolated rat hearts. Circulation. 87:1993;900-908.
24. Frass O, Sharma HS, Knøll R, Duncker DJ, McFalls EO, Verdouw PD, Schaper W. Enhanced gene expression of calcium regulatory proteins in stunned porcine myocardium. Cardiovasc Res. 27:1993;2037-2043.
25. Gambosová I, Bokník P, Kirchhefer U, Knapp J, Lüss H, Müller FU, Müller T, Vahlensieck U, Schmitz W, Bodor GS, Neumann J. Postnatal changes in contractile time parameters, calcium regulatory proteins, and phosphatases. Am J Physiol. 274:1998;H2123-H2132.
26. Gao Z-P, Downey HF, Fan W-L, Mallet RT. Does interstitial adenosine mediate acute hibernation of guinea pig myocardium? Cardiovasc Res. 29:1995;796-804.
27. Gao Z-P, Downey HF, Sun J, He M-X, Mallet R. Adenosine receptor blockade enhances glycolysis in hypoperfused guinea-pig myocardium. Cardiovasc Res. 33:1997;31-44.
28. Goto M, Cohen MV, van Wylen DGL, Downey JM. Attenuated purine production during subsequent ischemia in preconditioned rabbit myocardium is unrelated to the mechanisms of protection. J Mol Cell Cardiol. 28:1996;447-454.
29. Hammon Jr JW. Myocardial protection in the immature heart. Ann Thorac Surg. 60:1995;839-842.
30. Headrick J, Willis RJ. Mediation by adenosine of bradycardia in rat heart during graded global ischemia. Pflügers Arch. 412:1988;618-623.
31. Headrick JP, Willis RJ. Effects of adenosine antagonism and B-blockade during low-flow ischemia in rat heart. Clin Exp Pharmacol Physiol. 16:1989;885-891.
32. Headrick JP, Willis RJ. Adenosine formation and energy metabolism: a 31P-NMR study in isolated rat heart. Am J Physiol. 258:1990;H617-H624.
33. Heads RJ, Latchman DS, Yellon DM. Differential stress protein mRNA expression during early ischaemic preconditioning in the rabbit heart and its relationship to adenosine receptor function. J Mol Cell Cardiol. 27:1995;2133-2148.
34. Heads RJ, Punn A, Yellon DM. Cytoprotection of neonatal rat cardiomyocytes 24 hours following simulated ischemia is both adenosine A1-receptor and PKC-dependent (Abstract). J Mol Cell Cardiol. 28:1996;A47.
35. Heusch G, Schulz R. Hibernating myocardium: A review. J Mol Cell Cardiol. 28:1996;2359-2372.
36. Hohl CM, Livingston B, Hensley J, Altschuld RA. Calcium handling by sarcoplasmic reticulum of neonatal swine cardiac myocytes. Am J Physiol. 273:1997;H192-H199.
37. Ito B. Gradual onset of myocardial ischemia results in reduced myocardial infarction. Association with reduced contractile function and metabolic downregulation. Circulation. 91:1995;2058-2070.
38. Janier MF, Vanoverschelde J-LJ, Bergmann SR. Adenosine protects ischemic and reperfused myocardium by receptor-mediated mechanisms. Am J Physiol. 264:1993;H163-H170.
39. Knöll R, Arras M, Zimmermann R, Schaper J, Schaper W. Changes in gene expression following short coronary occlusions studied in porcine hearts with run-on assays. Cardiovasc Res. 28:1994;1062-1069.
40. Kollias-Baker C, Xu J, Pelleg A, Belardinelli L. Novel approach for enhancing atrioventricular nodal conduction delay mediated by endogenous adenosine. Circ Res. 75:1994;972-980.
41. Lasley RD, Mentzer Jr RM. Adenosine increases lactate release and delays onset of contracture during global low flow ischemia. Cardiovasc Res. 27:1993;96-101.
42. Lowry OH, Passonneau JV. A flexible system of enzymatic analysis. New York: Academic Press. 1972;147-217.
43. Lunde PK, Sejersted OM. Ryanodine binding sites measured in small skeletal muscle biopsies. Scand J Clin Lab Invest. 57:1997;569-580.
44. Lüss H, Bokník P, Heusch G, Müller FU, Neumann J, Schmitz W, Schulz R. Expression of calcium regulatory proteins in short-term hibernation and stunning in the in situ porcine heart. Cardiovasc Res. 37:1998;606-617.
45. Mahony L. Regulation of intracellular calcium concentration in the developing heart (Review). Cardiovasc Res. 31:1996;E61-E67.
46. Marban E. Excitation-contraction coupling in hi- bernating myocardium (Review). Basic Res Cardiol. 90:1995;19-22.
47. Martin BJ, Lasley RD, Mentzer Jr RM. Infarct size reduction with the nucleoside transport inhibitor R-75231 in swine. Am J Physiol. 272:1997;H1857-H1865.
48. Masuda M, Demeulemeester A, Chang-Chun C, Hendrikx M, van Belle H, Flameng W. Cardioprotective effects of nucleoside transport inhibition in rabbit hearts. A role of endogenous adenosine. Ann Thorac Surg. 52:1991;1300-1305.
49. Mohammed MU, Koide S, Shotsu A, Nakazawa ?. Perfusion delay causes unintentional ischemic preconditioning in isolated heart preparation (Abstract). Circulation. 92:1995;I-457.
50. Mubagwa K. Sarcoplasmic reticulum function during myocardial ischaemia and reperfusion (Review). Cardiovasc Res. 30:1995;166-175.
51. Mubagwa K, Mullane K, Flameng W. Role of adenosine in the heart and circulation. Cardiovasc Res. 32:1996;797-813.
52. Myrmel T, McCully JD, Malikin L, Krukenkamp IB, Levitsky S. Heat-shock protein 70 mRNA is induced by anaerobic metabolism in rat hearts. Circulation. 90 (part 2):1994;II299-II305.
53. 3H-ouabain binding sites in biopsies of skeletal muscle. Biochem Biophys Res Commun. 111:1983;319-325.
54. Offstad J, Kirkebøen KA, Ilebekk A, Downing SE. ATP gated potassium channels in acute myocardial hibernation and reperfusion. Cardiovasc Res. 28:1994;827-880.
55. Offstad J, Sommerschild HT, Ilebekk A, Kirkebøen KA, Downing SE. Repetitive stretching during myocardial low-flow ischemia impairs contractile function in isolated piglet hearts. J Mol Cell Cardiol. 29:1997;2997-3007.
56. Rosenberg JC, Rush BF. An enzymatic spectrophotometric determination of pyruvic and lactic acid in blood. Clin Chem. 12:1966;299-307.
57. Sack S, Mohri M, Arras M, Schwarz ER, Schaper W. Ischaemic preconditioning - time course of renewal in the pig. Cardiovasc Res. 27:1993;551-555.
58. Sambrook J, Fritsch EF, Maniatis T. Molecular cloning: A laboratory manual, 2nd ed. Cold Spring Harbour: Cold Spring Harbour Laboratory Press. 1989.
59. ATPchannels. Am J Physiol. 268:1995;H2294-H2301.
60. Sekili S, Jeroudi O, Tang X-L, Zughaib M, Sun J-Z, Bolli R. Effect of adenosine on myocardial "stunning" in the dog. Circ Res. 76:1995;82-94.
61. Sellevold OFM, Jynge P, Aarstad K. High performance liquid chromatography: a rapid isocratic method for determination of creatine compounds and adenine nucleotides in myocardial tissue. J Mol Cell Cardiol. 18:1986;517-527.
62. Sommerschild HT, Grund F, Offstad J, Jynge P, Ilebekk A, Kirkebøen KA. Importance of endogenous adenosine during ischemia and reperfusion in neonatal porcine hearts. Circulation. 96:1997;3094-3103.
63. Suileman J, Ashraf M. Adenosine attenuates calcium paradox injury: role of adenosine A1 receptor. Am J Physiol. 168:1995;C838-C845.
64. van Belle H. Nucleoside transport inhibition: a therapeutic approach to cardioprotection via adenosine? Cardiovasc Res. 27:1993;68-76.
65. van Belle H, Janssen PAJ. Comparative pharmacology of nucleoside transport inhibitors. Nucleosides & Nucleotides. 10:1991;975-982.
66. van Belle H, ver Donck K, Verheyen W. Role of nucleoside transport inhibition and endogenous adenosine in prevention of catecholamine induced death in rabbits. Cardiovasc Res. 27:1993;111-115.
67. Wainwright CL, Parrat JR, van Belle H. The antiarrhythmic effects of the nucleoside transporter inhibitor, R75231, in anaesthetized pigs. Br J Pharmacol. 109:1993;592-599.
68. Weiss JL, Fredriksen JW, Weisfeldt ML. Hemodynamic determinants of the time-course of fall in canine left ventricular pressure. J Clin Invest. 58:1976;751-760.