Granular cell tumor: A review of the pathology and histogenesis

Ultrastructural Pathology

Volumn 23, Issue 4, 1999, Pages 207-222

  Ordóñez, Nelson G ^a,b   Mackay, Bruce ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Granular cell tumor; Immunohistochemistry; Soft tissue tumors; Ultrastructure

Indexed keywords

CLINICAL FEATURE; DIFFERENTIAL DIAGNOSIS; ELECTRON MICROSCOPY; GRANULAR CELL TUMOR; HISTOGENESIS; HUMAN; IMMUNOHISTOCHEMISTRY; PATHOLOGY; PRIORITY JOURNAL; REVIEW;

ADULT; AGED; CELL NUCLEUS; FEMALE; GRANULAR CELL TUMOR; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, ELECTRON; MIDDLE AGED; ORGANELLES; SOFT TISSUE NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 0032868911     PISSN: 01913123     EISSN: None     Source Type: Journal    
DOI: 10.1080/019131299281545     Document Type: Review

References (154)

1. 1. Abrikossoff A. Über Myome, ausgehend von der quergestreiften willkürlichen Muskulatur. Virchows Arch Pathol Anat. 1926;260:215-233.
2. 2. Abrikossoff AI. Weitere Untersuchungen über Myoblastenmyome. Virchows Arch Pathol Anat. 1931;280:723-740.
3. 3. Murray MR. Cultural characteristics of three granular cell myoblastomas. Cancer. 1951;4:857-865.
4. 4. Enzinger RM, Weiss SW. Granular cell tumor. In: Soft Tissue Tumors, 3d ed. St. Louis: Mosby; 1995:864-875.
5. 5. Vance SF III, Hudson RP Jr. Granular cell myoblastoma: clinicopathologic study of forty-two patients. Am J Clin Pathol. 1969;52:208-211.
6. 6. Das Gupta TK, Chaudhuri PK. Granular cell tumors. In: Tumors of the Soft Tissues. Stamford, CT: Appleton & Lange; 1998:364-366.
7. 7. Baraf CS, Bender B. Multiple cutaneous granular cell myoblastomas. Arch Dermatol. 1964;89:242-246.
8. 8. Rifkin RH, Blocker SH, Palmer JO, Ternberg JL. Multiple granular cell tumors: a familial occurrence in children. Arch Surg. 1986;121:945-947.
9. 9. Goodstein ML, Eisele DW, Hyams VJ, Kashima HK. Multiple synchronous granular cell tumors of the upper aerodigestive tract. Otolaryngol Head Neck Surg. 1990;103:664-667.
10. 10. Lack EE, Worsham GF, Callihan MD, et al. Granular cell tumor: a clinicopathologic study of 110 patients. J Surg Oncol. 1980;13:301-316.
11. 11. Strong EW, McDivitt RW, Brasfield RD. Granular cell myoblastoma. Cancer. 1970;25:415-422.
12. 12. White SW, Gallager RL, Rodman OG. Multiple granular-cell tumors. J Dermatol Surg Oncol. 1980;6:57-61.
13. 13. Chaudhry AP, Jacobs MS, Sunder Raj M, Yamane GM, Jain R, Scharlock SE. A clinico-pathologic study of 50 adult oral granular cell tumors. J Oral Med. 1984;39-97-103.
14. 14. Moscovic EA, Azar HA. Multiple granular cell tumors ("myoblastomas") : case report with electron microscopic observations and review of the literature. Cancer. 1967;20:2032-2047.
15. 15. Peterson LJ. Granular-cell tumor: review of the literature and report of a case. Oral Surg Oral Med Oral Pathol. 1974;37:728-735.
16. 16. Worsaae N, Schwartz O, Pindborg JJ. Follow-up study of 14 oral granular cell tumors. Int J Oral Surg. 1979;8:133-139.
17. 17. Allaire GS, Laflamme P, Bourgouin P. Granular cell tumour of the orbit. Can J Ophthalmol. 1995;30:151-153.
18. 18. Farmer RW, Scher RL. Granular cell tumor of the larynx presenting with airway obstruction. Otol Head Neck Surg. 1998;118:874-876.
19. 19. Kamal SA, Othman EO. Granular cell tumour of the larynx. J Laryngol Otol. 1998;112:83-85.
20. 20. Lassaletta L, Alonso S, Granell J, Ballestin C, Serrano A, Alvarez-Vincent JJ. Synchronous glottic granular cell tumor and subglottic spindle cell carcinoma. Arch Otolaryngol Head Neck Surg. 1998;124:1031-1034.
21. 21. Victoria LV, Hoffman HT, Robinson RA. Granular cell tumor of the larynx. J Otolaryngol Otol. 1998;112:373-376.
22. 22. Nussbaum M, Haselkorn A. Granular cell myoblastoma in parotid gland. NY State J Med. 1972;72:2887-2888.
23. 23. Said-Al-Naief N, Ivanov K, Jones M, Som P, Urken M, Brandwein M. Granular cell tumor of the parotid. Ann Diagn Pathol. 1999;3:35-38.
24. 24. DeMay RM, Kay S. Granular cell tumor of the breast. Pathol Ann. 1984;19(pt 2):121-148.
25. 25. Hoess C, Freitag K, Kolben M, et al. FDG PET evaluation of granular cell tumor of the breast. J Nucl Med. 1998;39:1398-1401.
26. 26. Ingram DL, Mossler JA, Snowhite J, Leight GS, McCarty KS Jr. Granular cell tumors of the breast: steroid receptor analysis and localization of carcinoembryonic antigen, myoglobin, and S-100 protein. Arch Pathol Lab Med. 1984;108:897-901.
27. 27. Kommoss F, Mercer L, Schmidt RA, Talerman A. Granular cell tumor of the breast mimicking carcinoma in pregnancy. Obstet Gynecol. 1989;73:898-900.
28. 28. Andrade J de S, Bambirra EA, de Oliveira CA, et al. Granular cell tumor of the esophagus: a study of seven cases diagnosed by histologic examination of endoscopic biopsies. South Med J. 1987;80:852-854.
29. 29. Brady PG, Nord HJ, Connar RG. Granular cell tumor of the esophagus: natural history, diagnosis, and therapy. Dig Dis Sci. 1988;33:1329-1333.
30. 30. Cordoba A, Manrique M, Zozaya E, Penuela JMM, Gomez-Dorronsoro M, Querol I. Granular-cell tumor of the esophagus: report of a case with a cytologic diagnosis based on esophageal brushing. Diagn Cytopathol. 1998;19:455-457.
31. 31. Blanc-Jouvan F, Brambilla E, BosserayA, Junien-Lavillauroy C, Brambilla C, Paramelle B. Tracheo-bronchial granular cell tumors: apropos of 4 cases. Rev Mal Respir. 1991;8:85-88.
32. 32. Burton DM, Heffner DK, Patow CA. Granular cell tumors of the trachea. Laryngoscope. 1992;102:807-813.
33. 33. Majmudar B, Thomas J, Gorelkin L, Symbas PN. Respiratory obstruction caused by a multicentric granular cell tumor of the laryngotracheobronchial tree. Hum Pathol. 1981;12:283-286.
34. 34. Mulhollan TJ, Ro JY, El-Naggar AK, Sahin AA, Ayala AG. Granular cell tumor of the biliary tree. Am J Surg Pathol. 1992;16:204-209.
35. 35. Aisner SC, Khaneja S, Ramirez O. Multiple granular cell tumors of the gallbladder and biliary tree. Arch Pathol Lab Med. 1982;106:470-471.
36. 36. Butler JD, Brown KM. Granular cell tumor of the extrahepatic biliary tract. Am Surg. 1998;64:1033-1036.
37. 37. Eisen RN, Kirby WM, O'Quinn JL. Granular cell tumor of the biliary tree: a report of two cases and a review of the literature. Am J Surg Pathol. 1991;15:460-465.
38. 38. Ishii T, Iri H, Yamamoto S, Shinowawa Y, Sudoh M. Granular cell myoblastoma of the gallbladder. Am J Gastroenterol. 1977;68-38-44.
39. 39. Johnston MJ, Helwig EB. Granular cell tumors of the gastrointestinal tract and perianal region: a study of 74 cases. Dig Dis Sci. 1981;26:807-816.
40. 40. Seidler A, Burstein S, Drweiga W, Goldberg M. Granular cell tumor of the pancreas. J Clin Gastroenterol. 1986;8:207-209.
41. 41. Sekas G, Talamo TS, Julian TB. Obstruction of the pancreatic duct by a granular cell tumor. Dig Dis Sci. 1988;33:1334-1337.
42. 42. Yamashina M, Stemmermann GN. Granular cell tumor: unusual cause for mucocele of gallbladder. Am J Gastroenterol. 1984;79:701-703.
43. 43. Buley ID, Gatter KC, Kelly PM, Heryet A, Millard PR. Granular cell tumours revisited: an immunohistological and ultrastructural study. Histopathology. 1988;12:263-274.
44. 44. Bryant J. Granular cell tumor of penis and scrotum. Urology. 1995;45:332-334.
45. 45. Pour P, Althoff J, Cardesa A. Granular cells in tumors and in non-tumorous tissue. Arch Pathol. 1973;95:135-138.
46. 46. Suarez GM, Lewis RW. Granular cell tumor of the glans penis. J Urol. 1986;135:1252-1253.
47. 47. Brooks GG. Granular cell myoblastoma of the vulva in a 6-yr-old girl. AM J Obstet Gynecol. 1985;153:897-898.
48. 48. Degefu S, Dhurandhar HN, O'Quinn AG, Fuller PN. Granular cell tumor of the clitoris in pregnancy. Gynecol Oncol. 1984;19:246-251.
49. 49. Gal R, Dekel A, Ben-David M, Goldman JA, Kessler E. Granular cell myoblastoma of the cervix: case report. Br J Obstet Gynecol. 1988;95:720-722.
50. 50. Guenther L, Shum D. Granular cell tumor of the vulva. Pediat Dermatol. 1993;10:153-155.
51. 51. Horowitz IR, Copas P, Majmudar B. Granular cell tumors of the vulva. Am J Obstet Gynecol. 1995;173:1710-1713.
52. 52. Ortiz-Hidalgo C, de la Vega G, Moreno-Collado C. Granular cell tumor (Abrikossoff tumor) of the clitoris. Int J Dermatol. 1997;36:935-937.
53. 53. Carvalho GA, Lindeke A, Tatagiba M, Ostertag H, Samii M. Cranial granular cell tumor of trigeminal nerve: case report. J Neurosurg. 1994;81:795-798.
54. 54. Rao TV, Puri R, Reddy GNN. Intracranial trigeminal nerve granular cell myoblastoma: case report. J Neurosurg. 1983;59:706-709.
55. 55. Boraf CS, Bender B. Multiple cutaneous granular cell myoblastoma. Arch Dermatol. 1964;89:243-247.
56. 56. Hernandez OG, Haponik EF, Summer WR. Granular cell tumor of the bronchus: bronchoscopic and clinical features. Thorax. 1986;41:927-931.
57. 57. Goldblum JR, Rice TW, Zuccaro G, Richter JE. Granular cell tumors of the esophagus: a clinical and pathologic study of 13 cases. Ann Thorac Surg. 1996;62:860-865.
58. 58. Abdelwahab IF, Klein MJ. Granular cell tumor of the stomach: a case report and review of the literature. Am J Gastroenterol. 1983;78:71-76.
59. 59. Ross JS. Massive upper gastrointestinal hemorrhage from a granular cell tumor of the stomach. Am J Gastroenterol. 1977;68:595-598.
60. 60. Lafreniere R, Demetrick DJ, Benediktsson H. Granular cell neoplasm of the extrahepatic biliary tree: morphological, ultrastructural, and immunohistochemical study and review of the literature. J Surg Oncol. 1991;46:60-66.
61. 61. Mackay B, Elliott GB, Path FC, MacDougall JA. Granular cell myoblastoma of the cystic duct: report of a case with electron microscope observations. Can J Surg. 1968;11:44-51.
62. 62. Damiani S, Koerner FC, Dickersin GR, Cook MG, Eusebi V. Granular cell tumor of the breast. Virchows Arch A Pathol Anat. 1992;420:219-226.
63. 63. Slavin RE, Christie JD, Swedo J, Powell LC Jr. Locally aggressive granular cell tumor causing priapism of the crus of the clitoris: a light and ultrastructural study, with observations concerning the pathogenesis of fibrosis of the corpus cavernosum in priapism. Am J Surg Pathol. 1986;10:497-507.
64. 64. Mack TM. Sarcomas and other malignancies of soft tissue, retroperitoneum, peritoneum, pleura, heart, mediastinum, and spleen. Cancer. 1995;75:211-244.
65. 65. Tsuchida T, Okada K, Itoi E, Sato T, Sato K. Intramuscular malignant granular cell tumor. Skeletal Radiol. 1997;26:116-121.
66. 66. Nitze von H. Das sogenannte Myoblastenmyom und seine Maligne Verlaufsform. Z Laryngol Rhinol Otol Greggebiete. 1966;45:740-747.
67. 67. Chetty R, Kalan MR. Malignant granular cell tumor of the breast. J Surg Oncol. 1992;49:135-137.
68. 68. Crawford ES, DeBakey ME. Granular cell myoblastoma: two unusual cases. Cancer. 1953;6:786-789.
69. 69. Busanny-Caspari von M, Hammar CH. Zur Malignität der sogenannten Myoblastenmyome. Zentralbl Pathol Pathol Anat. 1958;98:401-406.
70. 70. Obiditsch-Mayer I, Salzer-Kuntschik M. Malignes, "getörntzelliges Neurom" sogenanntes, "Myoblastenmyom", des Oesophagus. Beitr Pathol Anat. 1961;125:357-373.
71. 71. Matsumoto H, Kojima Y, Inoue T, et al. A malignant granular cell tumor of the stomach: report of a case. Surg Today. 1996;26:119-122.
72. 72. Ravich A, Stout AP, Ravich RA. Malignant granular cell myoblastoma involving the urinary bladder. Ann Surg. 1945;121:361-372.
73. 73. Mȧgori von A, Szegvári M. Rezidivierender und metastasierender Abrikossoff Tumor der Vulva. Zentralb Pathol Pathol Anat. 1973;117:265-273.
74. 74. Robertson AJ, McIntosh W, Lamont P, Guthrie W. Malignant granular cell tumor (myoblastoma) of the vulva: report of a case and review of the literature. Histopathology. 1981;5:69-79.
75. 75. Sonobe H, Iwata J, Furihata M, Moriki T, Ohtsuki Y. Malignant granular cell tumor: report of a case and review of the literature. Pathol Res Pract. 1998;194:507-513.
76. 76. Usui M, Ishii S, Yamawaki S, Sasaki T, Minami A, Hizawa K. Malignant granular cell tumor of the radial nerve: an autopsy observation with electron microscopic and tissue culture studies. Cancer. 1977;39:1547-1555.
77. 77. Shimamura K, Osamura RY, Ueyama Y, et al. Malignant granular cell tumor of the right sciatic nerve: report of an autopsy case with electron microscopic. immunohistochemical, and enzyme histochemical studies. Cancer. 1984;53:524-529.
78. 78. Fanburg-Smith JC, Meis-Kindblom JM, Fante R, Kindblom L-G. Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation. Am J Surg Pathol. 1998;22:779-794.
79. 79. Lee J, Bhawan J, Wax F, Farber J. Plexiform granular cell tumor: a report of two cases. Am J Dermatopathol. 1994;16:537-541.
80. 80. Goette DK. Cutaneous horn overlying granular cell tumor. Int J Dermatol. 1987;26:598-599.
81. 81. Wolber RA, Talerman A, Wilkinson EJ, Clement PB. Vulvar granular cell tumors with pseudocarcinomatous hyperplasia: a comparative analysis with well-differentiated squamous carcinoma. Int J Gynecol Pathol. 1991;10:59-66.
82. 82. Said-Al-Naief N, Brandwein M, Lawson W, Gordon R, Lumerman H. Synchronous lingual granular cell tumor and squamous carcinoma: a case report and review of the literature. Arch Otol Head Neck. 1997;123:543-547.
83. 83. Gabriel JB Jr, Thomas L, Mendoza CB, Chauhan PM. Granular cell tumor of the bronchus coexisting with a bronchogenic adenocarcinoma: a case report. J Surg Oncol. 1983;24:103-106.
84. 84. Yamaguchi K, Maeda S, Kitamura K. Granular cell tumor of the stomach coincident with two early gastric carcinomas. Am J Gastroenterol. 1989;84:656-659.
85. 85. Mittal KR, True LD. Origin of granules in granular cell tumor: intracellular myelin formation with autodigestion. Arch Pathol Lab Med. 1988;112:302-303.
86. 86. Gamboa LG. Malignant granular cell myoblastoma. Arch Pathol. 1955;60:663-668.
87. 87. Strobel SL, Shah NT, Lucas JG, Tuttle SE. Granular-cell tumor of the breast: a cytologic, immunohistochemical and ultrastructural Study of two cases. Acta Cytol. 1985;29:598-601.
88. 88. Fuzesi L, Hoer PW, Schmidt W. Exfoliative cytology of multiple endobronchial granular cell tumor. Acta Cytol. 1989;33:516-518.
89. 89. Glant MD, Wall RW, Ransburg R. Endobronchial granular cell tumor: cytology of a new case and review of the literature. Acta Cytol. 1979;23:477-482.
90. 90. Medart WS Jr, Whiddon MC, Shanbhag N, Goytizola EC. Granular cell myoblastoma of the bronchus: report of two cases, one diagnosed by exfoliative cytology. J Thorac Cardiovasc Surg. 1973;65:214-215.
91. 91. Naib ZM, Goldstein MG. Exfoliative cytology of a case of granular cell myoblastoma. Dis Chest. 1962;42:645-647.
92. 92. Thomas L, Risbud M, Gabriel JB, Caces W, Chauhan PM. Cytomorphology of granular-cell tumor of the bronchus: a case report. Acta Cytol. 1984;28:129-132.
93. 93. Franzen S, Stenkvist B. Diagnosis of granular cell myoblastoma by fine-needle aspiration biopsy. Acta Pathol Microbiol Scand. 1963;72:391-395.
94. 94. Hill S, Walker S, Bode JC, Emmermann H. Granular-cell tumor of the stomach and esophagus. Dtsch Med Wochenschr. 1991;116:895-898.
95. 95. Löwhagen T, Rubio CA. The cytology of granular cell myoblastoma of breast: report of a case. Acta Cytol. 1977;21:314-315.
96. 96. Smith AR, Gilbert CF, Strausbauch P, Silverman JF. Fine needle aspiration cytology of a mediastinal granular cell tumor with histologic confirmation and ancillary studies: a case report. Acta Cytol. 1998;42:1011-1016.
97. 97. Uzoaru I, Firfer B, Ray V, Hubbard-Shepard M, Rhee H. Malignant granular cell tumor. Arch Pathol Lab Med. 1992;116:206-208.
98. 98. Sirgi KE, Sneige N, Fanning TV, Fornage BD, Ordóñez NG, Swanson PE. Fine-needle aspirates of granular cell lesions of the breast: report of three cases, with emphasis on differential diagnosis and utility of immunostaining for CD68 (KP1). Diagn Cytopathol. 1996;15:403-408.
99. 99. Miettinen M, Lehtonen E, Lehtola H, Ekblom P, Lehto VP, Virtanen I. Histogenesis of granular cell tumor: an immunohistochemical and ultrastructural study. J Pathol. 1984;142:221-229.
100. 100. Nathrath WBJ, Remberger K. Immunohistochemical study of granular cell tumours. Demonstration of neurone specific enolase, S-100 protein, laminin and alpha-1-antichymotrypsin. Virchows Arch Pathol Anat. 1986;408:421-434.
101. 102. Armin A, Connelly EM, Rowden G. An immunoperoxidase investigation of S-100 protein in granular cell myoblastomas: evidence for Schwann cell derivation. Am J Clin Pathol. 1983;79:37-44.
102. 102. Cavaliere A, Sidoni A, Ferri I, Falini B. Granular cell tumor: an immunohistochemical study. Tumori. 1994;80:224-228.
103. 103. Fliss DM, Puterman M, Zirkin H, Leiberman A. Granular cell lesions in head and neck: a clinicopathological study. J Surg Oncol. 1989;42:154-160.
104. 104. Kurtin PJ, Bonin DM. Immunohistochemical demonstration of the lysosome-associated glycoprotein CD68 (KP-1) in granular cell tumors and schwannomas. Hum Pathol. 1994;25:1172-1178.
105. 105. Mazur MT, Shultz JJ, Myers L. Granular cell tumor: immunohistochemical analysis of 21 benign tumors and one malignant tumor. Arch Pathol Lab Med. 1990;114:692-696.
106. 106. Mukai M. Immunohistochemical localization of S-100 protein and peripheral nerve myelin proteins (P2 protein, P0 protein) in granular cell tumors. Am J Pathol. 1983;112:139-146.
107. 107. Nakazato Y, Ishizeki J, Takahashi K, Yamaguchi H. Immunohistochemical localization of S-100 protein in granular cell myoblastoma. Cancer. 1982;49:1624-1628.
108. 108. Regezi JA, Zarbo RJ, Courtney RM, Crissman JD. Immunoreactivity of granular cell lesions of skin, mucosa, and jaw. Cancer. 1989;64:1455-1460.
109. 109. Smolle J, Walter GT, Kerl H. Myelin-associated glycoprotein in neurogenic tumors of the skin: an immunohistological study using Leu-7 monoclonal antibody. Arch Dermatol Res. 1985;277:141.
110. 110. Stefansson K, Wollmann RL. S-100 protein in granular cell tumors (granular cell myoblastomas). Cancer. 1982;49:1834-1838.
111. 111. Stewart CM, Watson RE, Eversole LR, Fischlschweiger W, Leider AS. Oral granular cell tumors: a clinicopathologic and immunocytochemical study. Oral Surg Oral Med Oral Pathol. 1988;65:427-435.
112. 112. Tsang WYM, Chan JKC. KP1 (CD68) staining of granular cell neoplasms: Is KPI a marker for lysosomes rather than the histiocytic lineage? Histopathology. 1992;21:84-86.
113. 113. Williams HK, Williams DM. Oral granular cell tumors: a histological and immunocytochemical study. J Oral Pathol Med. 1997;26:164-169.
114. 114. Penneys N, Adachi K, Ziegels-Weissman J, Nadji M. Granular cell tumors of the skin contain myelin basic protein. Arch Pathol Lab Med. 1983;107:302-303.
115. 115. Clark HB, Minesky JJ, Agrawal D, Agrawal HC. Myelin basic protein and P2 protein are not immunohistochemical markers for Schwann cell neoplasms: a comparative study using antisera to S-100, P2, and myelin basic proteins. Am J Pathol. 1985;121:96-101.
116. 116. Miettinen M, Ekfors T. Alveolar soft part sarcoma: immunohistochemical evidence for muscle cell differentiation. Am J Clin Pathol. 1990;93:32-38.
117. 117. Ma CK, Zarbo RJ, Gown AM. Immunohistochemical characterization of atypical fibroxanthoma and dermatofibrosarcoma protuberans. Am J Clin Pathol. 1992;97:478-483.
118. 118. Mentzel T, Wadden C, Fletcher CDM. Granular cell change in smooth muscle tumours of skin and soft tissue. Histopathology. 1994;24:223-231.
119. 119. Vennegoor C, Calafat J, Hageman P, van Buitenen. Biochemical characterization and cellular localization of a formalin-resistant melanoma-associated antigen reacting with monoclonal antibody NK1/C3. Int J Cancer. 1985;35:287-295.
120. 120. Shousha S, Lyssiotis T. Granular cell myoblastoma: positive staining for carcinoembryonic antigen. J Clin Pathol. 1979;32:219-224.
121. 121. Weiss LM, Arber DA, Chang KL. CD68: a review. Appl Immunohistochem. 1994;2:2-8.
122. 122. Dingemans RP, Mooi WJ, van den Bergh Weerman MA. Angulated lysosomes. Ultrastruct Pathol. 1983;5:113-122.
123. 123. Ghadially FN. Ultrastructure of the Cell and Matrix, 4th ed. London. Butterworth; 1997:738-740.
124. 124. Al-Sarraf M, Loud AV, Vaitkevicius VK. Malignant granular cell tumor: histochemical and electron microscopic study. Arch Pathol. 1971;91:550-558.
125. 125. Steffelaar JW, Nap M, Haelst von UJGM. Malignant granular cell tumor: report of a case with special reference to carcinoembryonic antigen. Am J Surg Pathol. 1982;6:665-672.
126. 126. Anderson PJ, Kirkland P, Schafler K, Moss AL. Congenital gingival granular cell tumor. J R Soc Med. 1996;89:53P-54P.
127. 127. Lack EE, Worsham GF, Callihan MD, Crawford BE, Vawter GF. Gingival granular cell tumors of the newborn (congenital "epulis") : a clinical and pathologic study of 21 patients. Am J Surg Pathol. 1981;5:37-46.
128. 128. Lack EE, Perez-Atayde AR, McGill TJ, Vawter GF. Gingival granular cell tumor of the newborn (congenital "epulis") : ultrastructural observations relating to histogenesis. Hum Pathol. 1982;13:686-689.
129. 129. Ophir D, Lifschitz B, Mogilner BM. Congenital granular cell tumor of the tongue. Head Neck Surg. 1987;9:250-252.
130. 130. Tucker MC, Rusnock EJ, Azumi H, Hoy GR, Lack EE. Gingival granular cell tumors of the newborn: an ultrastructural and immunohistochemical study. Arch Pathol Lab Med. 1990;114:895-898.
131. 131. Dina R, Marchetti C, Vallania G, Corinaldesi G, Eusebi V. Granular cell ameloblastoma: an immunocytochemical study. Pathol Res Pract. 1996;192:541-546.
132. 132. Rühl GH, Akuamoa-Boateng E. Granular cells in odontogenic and non-odontogenic tumours. Virchows Arch A Pathol Anat. 1989;415:403-409.
133. 133. Roncaroli F, Rossi R, Severi B, Martinelli GN, Eusebi V. Epithelioid leiommyoma of the breast with granular change: a case report. Hum Pathol. 1993;24:1260-1263.
134. 134. LeBoit PE, Barr RJ, Burall S, et al. Primitive polypoid granular-cell tumor and other cutaneous granular-cell neoplasms of apparent nonneural origin. Am J Surg Pathol. 1991;15:48-58.
135. 135. Suster S, Rosen LB, Sanchez JL. Granular leiomyosarcoma of the skin. Am J Dermatopathol. 1988;10:234-239.
136. 136. Hitchcock MG, Hurt MA, Santa Cruz DJ. Cutaneous granular cell angiosarcoma. J Cutan Pathol. 1994;21:256-262.
137. 137. Tanimura A, Nagayama K, Nakamura Y, Tanaka S, Tanaka T. Malignant fibrous histiocytoma with granular cells, mimicking a granular cell tumor: light, electron microscopic and immunohistochemical observation of a case. Acta Pathol Jpn. 1985;35:1555-1560.
138. 138. Banerjee SS, Harris M, Eyden BP, Hamid BNA. Granular cell variant of dermatofibrosarcoma protuberans. Histopathology. 1990;17:375-378.
139. 139. Mrak RE, Baker GF. Granular cell basal cell carcinoma. J Cutan Pathol. 1987;14:37-42.
140. 140. Leroux R, Delarue J. Sur trois cas de tumeurs à cellules granuleuses de la cavité buccale. Bull Assoc Franc Etude Cancer. 1939;28:427-447.
141. 141. Azzopardi JG. Histogenesis of the granular cell "myoblastoma." J Pathol Bacteriol. 1956;71:85-94.
142. 142. Gullino P. Sui cosidetti "tumori di mioblasti" interpretati comi granulomi di probabile origin parasitaria. Tumori. 1946;20:102-128.
143. 143. Holle G. Ueber die Deutung der sogenannten Myoblastenmyome als Speicherzellgeschwülste auf Grund einer besonderen färberischen Reaktion. Zentralbl F Allg Path U Path Anat. 1941;76:244-247.
144. 144. Pearse AGE. The histogenesis of granular cell myoblastoma (granular cell perineural fibroblastoma). J Pathol Bacteriol. 1950;62:351-362.
145. 145. Fisher ER, Wechsler H. Granular cell myoblastoma: misnomer. Electron microscopy and histochemical evidence concerning its Schwann cell derivation and nature (granular cell schwannoma), Cancer. 1962;15:936-954.
146. 146. Garancis JC, Komorowski RA, Kuzma JF. Granular cell myoblastoma. Cancer. 1970;25:542-550.
147. 147. Sobel HJ, Marquet M, Arvin E, et al. Granular cell myoblastoma: an electron microscopic and cytochemical study illustrating the genesis of granules, and aging of myoblastoma cells. Am J Pathol. 1971;65:59.
148. 148. Aparicio SR, Lumsden CE. Light and electron microscopic studies on the granular cell myoblastoma of the tongue. J Pathol. 1969;97:339.
149. 149. Regezi JA, Batsakis JG, Courtney RM. Granular cell tumors of the head and neck. J Oral Surg. 1979;37:402-406.
150. 150. Feyrter F. Ueber eine eigenartige Geschultsform des Nervengewebes im menslichen Verdauunsschlauch. Virchows Arch Pathol Anat Physiol. 1935;285:480-501.
151. 151. May M, Beckford NS, Bedetti CD. Granular cell tumor of facial nerve diagnosed at surgery for idiopathic facial nerve paralysis. Otolaryngol Head Neck Surg. 1985;93:122-126.
152. 152. Abenoza P, Sibley RK. Granular cell myoma and schwannoma: fine structural and immunohistochemical study. Ultrastruct Pathol. 1987;11:19-28.
153. 153. Takei Y, Mirra SS, Miles ML. Eosinophilic granular cells in oligodendrogliomas: an ultrastructural study. Cancer. 1976;38:1968-1976.
154. 154. Rosaì J. Granular cell tumor. In: Ackerman's Surgical Pathology, Vol 2, 8th ed. St. Louis: Mosby; 1996;2096-2098.