High-dose melphalan with autologous stem-cell rescue in metastatic rhabdomyosarcoma

Journal of Clinical Oncology

Volumn 17, Issue 9, 1999, Pages 2796-2803

  Carli, M ^a   Colombatti, R ^a   Oberlin, O ^a   Stevens, M ^a   Masiero, L ^a   Frascella, E ^a   Koscielniak, E ^a   Treuner, J ^a   Pinkerton, C R ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BUSULFAN; CARBOPLATIN; ETOPOSIDE; MELPHALAN; THIOTEPA;

ADOLESCENT; ADULT; ARTICLE; AUTOLOGOUS BONE MARROW TRANSPLANTATION; CANCER COMBINATION CHEMOTHERAPY; CANCER LOCALIZATION; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER REGRESSION; CANCER SURGERY; CANCER SURVIVAL; CELL TYPE; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG INDUCED DISEASE; DRUG MEGADOSE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; INFANT; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; METASTASIS; MULTIMODALITY CANCER THERAPY; ONSET AGE; PRIORITY JOURNAL; RHABDOMYOSARCOMA; TREATMENT OUTCOME;

EID: 0032868078     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/jco.1999.17.9.2796     Document Type: Article

References (33)

1. Crist W, Gehan EA, Ragab AH, et al: The Third Intergroup Rhabdomyosarcoma Study. J Clin Oncol 13:610-630, 1995
2. Koscielniak E, Rodary C, Flamant F, et al: Metastatic rhabdomyosarcoma and histologically similar tumours in childhood: A restrospective European multicentre analysis. Med Pediatr Oncol 20:209-214, 1992
3. Carli M, Colombatti R, Pinkerton R, et al: Prognostic factors in children with metastatic rhabdomiosarcoma: Results of the European Intergroup Studies (EIS) MMT '89 and MMT '91. Proc SIOP Med Pediatr Oncol 29:324, 1997 (abstr 0-32)
4. Anderson JR, Ruby E, Link M, et al: Identification of a favorable subset of patients (PTS) with metastatic (MET) rhabdomyosarcoma (RMS): A report from the Intergroup Rhabdomyosarcoma Study Group (IRSG). Proc Am Soc Clin Oncol 16:510, 1997 (abstr 1836)
5. Atra A, Pinkerton CR: Autologous stem cell transplantation in solid tumours of childhood. Ann Med 28:159-164, 1996
6. Houghton JA, Cook RL, Lutz PJ: Melphalan: A potential new agent in the treatment of childhood rhabdomyosarcoma. Cancer Treat Rep 69:91-96, 1985
7. Belasco JB, Mitchell CD, Rohrbaugh T, et al: IV Melphalan in children. Cancer Treat Rep 1:129-133, 1987
8. Horowitz M, Etcubanas E, Christesed M, et al: Phase II testing of melphalan in children with newly diagnosed rhabdomyosarcoma: A model for anticancer drug development. J Clin Oncol 6:308-314, 1988
9. Bagnulo S, Perez DJ, Barrett A, et al: High dose melphalan and autologous bone marrow transplantation for solid tumours of childhood. Eur Paediatr Haematol Oncol 2:129-133, 1985
10. Pinkerton CR, Groot-Loonen, Barrett J, et al: Rapid VAC high dose melphalan regimen: A novel chemotherapy approach for childhood soft tissue sarcomas. Br J Cancer 64:381-385, 1991
11. Pinkerton CR: Megatherapy for soft tissue sarcomas: EBMT experience. Bone Marrow Transplant 7:120-122, 1991
12. Carli M, Pinkerton P, Frascella E, et al: Intensive chemotherapy for metastatic sarcoma in children. SIOP European Intergroup Study MM89. Proc Am Soc Clin Oncol 12:410, 1993 (abstr 1404)
13. Pearson ES, Hartley HO: Biometrika Tables for Statisticians. Cambridge, England, Cambridge University Press, 1966
14. Kaplan EL, Meier P: Nonparametric estimation from incomplete observation. J Am Stat Assoc 53:457-481, 1958
15. Cox DR, Oakes D: Analysis of Survival Data. London, England, Chapman and Hall, 1992
16. Flamant F, Rodary C, Rey A, et al: Treatment of non-metastatic rhabdomyosarcomas in childhood and adolescence: Results of the second study of the International Society of Paediatric Oncology MMT84. Eur J Cancer 34:1050-1062, 1998
17. Pinkerton CR: ENSGI randomised study on high dose melphalan in neuroblastoma. Bone Marrow Transplant 7:112-113, 1991 (suppl 3)
18. Dumontet C, Biron P, Bouffet E, et al: High dose chemotherapy with ABMT in soft tissue sarcoma: A report of 22 cases. Bone Marrow Transplant 20:405-408, 1992
19. Blay JY, Bouhour D, Brunat-Mentigny M, et al: High dose chemotherapy (VIC) and bone marrow support in advanced sarcomas. Proc Am Clin Oncol 13:479, 1994 (abstr 1672)
20. Horowitz ME, Kinsella TJ, Wexler LH, et al: Total-body irradiation and autologous bone marrow transplant in the treatment of high-risk Ewing's sarcoma and rhabdomyosarcoma. J Clin Oncol 11:1911-1918, 1993
21. Emminger W, Emminger-Schmidmeier W, Peters C, et al: Is treatment intensification by adding etoposide and carboplatin to fractionated total body irradiation and melphalan acceptable in children with solid tumors with respect to toxicity? Bone Marrow Transplant 8:119-123, 1991
22. Pinkerton R, Philip T, Barrett A, et al: Massive therapy with total body irradiation and bone marrow transplantation in children with relapsed or advanced rhabdomyosarcoma. Proc SIOP XVII Meeting, Venice, Italy, September 30-October 4, 1985
23. Hoover ML, Walterhouse DO, Morgan EM, et al: High dose chemotherapy with peripheral blood stem cell rescue (HDC/PBSCR) as consolidation for stage IV rhabdomyosarcoma (RMS). Proc Am Clin Oncol 15:351, 1996 (abstr 1031)
24. Hartmann O, Benhampou E, Beaujean F, et al: High-dose busulfan and cyclophosphamide with autologous bone marrow transplantation support in advanced malignancies in children: A phase II study. J Clin Oncol 4:1804-1810, 1986
25. Ozkaynak MF, Matthay K, Cairo M, et al: A non TBI regimen for autologous hematopoietic stem cell transplantation in pediatric solid tumors. Proc Am Clin Oncol 16:514, 1997 (abstr 1848)
26. Koscielniak E, Klingebiel TH, Peters C, et al: Do patients with metastatic and recurrent rhabdomyosarcoma benefit from high-dose therapy with hematopoietic rescue? Report of the German/Austrian Pediatric Bone Marrow Transplantation Group. Bone Marrow Transplant 19:227-231, 1997
27. Boulad F, Kernan NA, LaQuaglia MP, et al: High dose induction chemoradiotherapy followed by autologous bone marrow transplantation as consolidation therapy in rhabdomyosarcoma, extraosseous Ewing's sarcoma, and undifferentiated sarcoma. J Clin Oncol 16:1697-1706, 1998
28. Pinkerton CR: Massive chemotherapy followed by bone marrow graft in paediatric oncology: Arguments against. Bull Cancer 82:4245, 1995
29. Grupp SA, Diller J, Gorlin J, et al: Feasibility of double peripheral blood progenitor cell (PBPC) transplant in children with advanced neuroblastoma and sarcomas. Proc Am Soc Clin Oncol 15:465, 1996 (abstr 1465)
30. Hartmann O, Benhamou E, Beaujean F, et al: Repeated high dose chemotherapy followed by purged autologous bone marrow transplantation as consolidation therapy in metastatic neuroblastoma. J Clin Oncol 5:1205-1211, 1987
31. Foot ABM, Pinkerton CR, Stevens M, et al: Sequential rapid high dose single agent consolidation therapy for metastatic sarcoma in children. Proc SIOP Med Pediatr Oncol 29:409, 1997 (abstr P-89)
32. Valteau-Couanet D, Lucidarme N, Pein F, et al: High dose thiotepa with hematopoietic stem cell support in children with solid tumors: A phase D study. Proc Am Soc Clin Oncol 15:464, 1996 (abstr 1458)
33. Shapall EJ, Cagnoni PJ, Gehling U, et al: Bone marrow purging, in Armitage JO, Antman KH (eds): High Dose Cancer Therapy. Baltimore, MD, Williams and Wilkins, 1995, pp 289-318