Dictyostelium myosin II G680V suppressors exhibit overlapping spectra of biochemical phenotypes including facilitated phosphate release

Genetics

Volumn 153, Issue 1, 1999, Pages 107-116

  Wu, Yuan ^a,c   Nejad, Mike ^b,c   Patterson, Bruce ^c,d  

^a ELI LILLY AND COMPANY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c University of Arizona   (United States)

^d UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ADENOSINE TRIPHOSPHATASE; MYOSIN; PHOSPHATE;

ACTIN MYOSIN INTERACTION; ALLELISM; ARTICLE; CRYSTAL STRUCTURE; DICTYOSTELIUM; ENZYME ACTIVITY; GENE CLUSTER; GENE FUNCTION; GENE MUTATION; MULTIGENE FAMILY; NONHUMAN; PHENOTYPE; PHOSPHATE METABOLISM; PRIORITY JOURNAL; SUPPRESSOR GENE;

ACTINS; ADENOSINE TRIPHOSPHATASES; AMINO ACID SUBSTITUTION; ANIMALS; CYTOSKELETON; DICTYOSTELIUM; KINETICS; MODELS, MOLECULAR; MOLECULAR MOTOR PROTEINS; MYOSINS; PHENOTYPE; PHOSPHATES; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPRESSION, GENETIC;

EID: 0032867566     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. AGUADO-VELASCO, C., and E. R. KUCZMARSKI, 1993 Contraction of reconstituted Dictyostelium cytoskeletons: an apparent role for higher order associations among myosin filaments. Cell Motil. Cytoskelet. 26: 103-114.
2. FRIEDMAN, A. L., M. A. GEEVES, D. J. MANSTEIN and J. A. SPUDICH, 1998 Kinetic characterization of myosin head fragments with long-lived myosin-ATP states. Biochemistry 37: 9679-9687.
3. GIESE, K., and J. A. SPUDICH, 1997 Phenotypicallyselected mutations in myosin's actin binding domain demonstrate intermolecular contacts important for motor function. Biochemistry 36: 8465-8473.
4. JARVIK, J., and D. BOTSTEIN, 1975 Conditional-lethal mutations that suppress genetic defects in morphogenesis by altering structural proteins. Proc. Natl. Acad. Sci. USA 72: 2738-2742.
5. KUCZMARSKI, E. R., L. PALIVOS, C. AGUADO and Z. YAO, 1991 Stopped-flow measurement of cytoskeletal contraction: Dictyostelium myosin II is specifically required for contraction of amoeba cytoskeletons. J. Cell Biol. 114: 1191-1199.
6. MANSTEIN, D. J., and D. M. HUNT, 1995 Overexpression of myosin motor domains in Dictyostelium: screening of transformants and purification of the affinity tagged protein. J. Muscle Res. Cell Motil. 16: 325.
7. PATTERSON, B., 1998 Intragenic suppressors of Dictyostelium myosin G680 mutants demarcate discrete structural elements: implications for conformational states of the motor. Genetics 149: 1799-1807.
8. PATTERSON, B., K. M. RUPPEL, Y. WU and J. A. SPUDICH, 1997 Cold-sensitive mutants G680V and G691C of Dictyostelium myosin II confer dramatically different biochemical defects. J. Biol. Chem. 272: 27612-27617.
9. SMITH, C. A., and I. RAYMENT, 1996 X-ray structure of the magnesimn(II)·ADP·vanadate complex of the Dictyostelium discoideum myosin motor domain to 1.9A resolution. Biochemistry 35:5404-5417.
10. SPUDICH, J. A., and S. WATT, 1971 The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin. J. Biol. Chem. 246: 4866-4871.
11. SUSSMAN, M., 1987 Cultivation and synchronous morphogenesis of Dictyostelium under controlled experimental conditions, pp. 9-29 in Dictyostelium discoideum: Molecular Approaches to Cell Biology, edited by J. A. SPUDICH. Academic Press, Orlando, FL.
12. WHITE, H. D., 1982 Special instrumentation and techniques for kinetic studies of contractile systems, pp. 698-708 in Structural and Contractile Proteins, Part B. The Contractile Apparatus and the Cytoskeleton, edited by D.W. FREDERIKSEN and L. W. CUNNINGHAM. Academic Press, New York.
13. YOUNT, R. G., D. LAWSON, and I. RAYMENT, 1995 Is myosin a "back door" enzyme? Biophys. J. 68: 44s-49s.