Norepinephrine transporter gene polymorphism is not associated with susceptibility to major depression

Psychiatry Research

Volumn 87, Issue 1, 1999, Pages 1-5

  Owen, Diana ^a   Du, Lisheng ^a   Bakish, David ^a   Lapierre, Yvon D ^a   Hrdina, Pavel D ^a  

^a Royal's Institute of Mental Health Research   (Canada)

Author keywords

Affective disorders; Allelic association; Genetics; Norepinephrine transporter gene

Indexed keywords

NORADRENALIN;

ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; DEPRESSION; DISEASE PREDISPOSITION; DNA DETERMINATION; EXON; FEMALE; GENE; GENETIC ANALYSIS; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; MUTATION; PRIORITY JOURNAL;

ADULT; ALLELES; CARRIER PROTEINS; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; DEPRESSIVE DISORDER; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MUTATION, MISSENSE; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; SUICIDE; SYMPORTERS;

EID: 0032867437     PISSN: 01651781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1781(99)00050-5     Document Type: Article

References (17)

1. Dajas F., Barbeito L., Cervenansky C. An association between norepinephrine-to-epinephrine ratio and suicidal ideation in depression. (Letter) American Journal of Psychiatry. 143:1986;5.
2. Garcia-Sevilla J.A., Zis A.P., Zelnik T.C., Smith C.B. Tricyclic antidepressant drug treatment decreases alpha 2-adrenoreceptors on human platelet membranes. European Journal of Pharmacology. 69:1981;121-123.
3. Gemmell N.J., Akiyama S. An efficient method for the extraction of DNA from vertebrate tissues. Trends in Genetics. 12:1996;338-339.
4. Hadley D., Hoff M., Holik J., Reimherr F., Wender P., Coon H., Byerley W. Manic-depression and the norepinephrine transporter gene. Human Heredity. 45:1995;165-168.
5. Kaye W.H., Ballenger J.C., Lydiard R.B., Stuart G.W., Laraia M.T., O'Neil P., Fossey M.D., Stevens V., Lesser S., Hsu G. CSF monoamine levels in normal-weight bulimia: evidence for abnormal noradrenergic activity. American Journal of Psychiatry. 147:1990;225-229.
6. Kennedy S.H., Parikh S.V., Shapiro C.M. Defeating Depression. 1998;Joli Joco Publications, Thornhill.
7. Klimek V., Stockmeier C., Overholser J., Meltzer H.Y., Kalka S., Dilley G., Ordway G.A. Reduced levels of norepinephrine transporters in the locus coeruleus in major depression. Journal of Neuroscience. 17:1997;8451-8458.
8. Lake C.R., Pickar D., Ziegler M.G., Lipper S., Slater S., Murphy D.L. High plasma norepinephrine levels in patients with major affective disorder. American Journal of Psychiatry. 139:1982;1315-1318.
9. Nurnberger J.I., Goldin L.R., Gershon E.S. Genetics of psychiatric disorders. Winokur G., Clayton P.J. The Medical Basis of Psychiatry. 1994;459-491 Saunders, Philadelphia.
10. Ogilvie A.D., Battersby S., Bubb V.J., Fink G., Harmar A.J., Goodwin G.M., Smith C.A.D. Polymorphism in serotonin transporter gene associated with susceptibility to major depression. Lancet. 347:1996;731-733.
11. Roy A., Pickar D., Linnoila M., Potter W.Z. Plasma norepinephrine levels in affective disorders: relationship to melancholia. Archives of General Psychiatry. 42:1985;1181-1185.
12. Roy A., Pickar D., Dejong J., Karoum F., Linnoila M. Norepinephrine and its metabolites in cerebrospinal fluid, plasma and urine: relationship to hypothalmic-pituitary-adrenal axis function in depression. Archives of General Psychiatry. 45:1988;849-857.
13. Stöber G., Nöthen M.M., Porzgen P., Bruss M., Bonisch H., Knapp M., Beckmann H., Propping P. Systematic search for variation in the human norepinephrine transporter gene: identification of five naturally occurring missense mutations and study of associations with major psychiatric disorders. American Journal of Medical Genetics (Neuropsychiatric Genetics). 67:1996;523-532.
14. Stoline A.M. To sleep-perchance to dream.of affective disorders. (Letter) American Journal of Psychiatry. 153:1996;134-135.
15. Taylor D.P., Carter R.B., Eison A.S., Mullins U.L., Smith H.L., Torrente J.R., Wright R.N., Yocca F.D. Pharmacology and neurochemistry of nefazodone, a novel antidepressant drug. Journal of Clinical Psychiatry. 36(Suppl. 6):1995;3-11.
16. Veith R.C., Lewis N., Linares O.A., Barnes R.F., Raskind M.A., Villacres E.C., Murburg H.M., Ashleigh E.A., Castillo S., Peskind E.R., Pascualy M., Halter J.B. Sympathetic nervous system activity in major depression. Archives of General Psychiatry. 51:1994;411-422.
17. Waldmeier P.C. Noradrenergic transmission in depression: under- or overfunction? Pharmacopsychiatry. 14:1981;3-9.