Therapeutic options in small abdominal aneurysms: The role of in vitro studies

Annals of the New York Academy of Sciences

Volumn 878, Issue , 1999, Pages 724-727

  Thompson, M M ^a,b   Boyle, J R ^a   Crowther, M ^a   Goodall, S ^a   Wills, A ^a   Loftus, I M ^a   Bell, P R F ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b LEICESTER ROYAL INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMLODIPINE; DOXYCYCLINE; ELASTASE; ELASTIN;

ABDOMEN; ANEURYSM; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; NONHUMAN; ORGAN CULTURE; SWINE;

ANIMALIA; SUS SCROFA;

EID: 0032866263     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1999.tb07773.x     Document Type: Conference Paper

References (4)

1. 1. Wills, A., M.M. Thompson, M. Crowther, N.P. Brindle, A. Nasim, R.D. Sayers et al. 1996. Elastase-induced matrix degradation in arterial organ cultures: an in vitro model of ancurysmal disease. J. Vasc. Surg. 24: 667-679.
2. 2. Thompson, M.M., A. Wills, E. McDermott, M. Crowther, N. Brindle & P.R.F. Bell. 1996. An in vitro model of aneurysmal disease: effect of leukocyte infiltration and shear stress on MMP production within the arterial wall. Ann. N.Y. Acad. Sci. 800: 270-273.
3. 3. Boyle, J.R., E. McDermott, M. Crowther, A. Wills, P.R.F. Bell & M.M. Thompson. 1998. Doxycycline inhibits elastin degradation and reduces metalloproteinase activity in a model of aneurysmal disease. J. Vasc. Surg. 27: 354-361.
4. 4. Boyle, J.R., I.M. Loftus, S. Goodall, M. Crowther, P.R.F. Bell & M.M. Thompson. 1998. Amlodipine potentiates metalloproteinase activity and accelerated elastin degradation in a model of aneurysmal disease. Eur. J. Vasc. Endovasc. Surg. In press.