Mitochondrial DNA deletion associated oxidative stress and severe male osteoporosis

Osteoporosis International

Volumn 10, Issue 2, 1999, Pages 143-149

  Varanasi, S S ^a   Francis, R M ^a   Berger, C E M ^a   Papiha, S S ^a   Datta, H K ^a,b  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Lactic acidosis; Mitochondrial DNA; Osteoporosis; Oxidative stress

Indexed keywords

MITOCHONDRIAL DNA;

ADULT; AGED; ARTICLE; BONE DENSITY; BONE MINERAL; CLINICAL ARTICLE; CONTROLLED STUDY; GENE DELETION; GENE SEQUENCE; HUMAN; HUMAN CELL; LACTIC ACIDOSIS; MALE; OSTEOPOROSIS; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SOUTHERN BLOTTING; VERTEBRA FRACTURE;

ADENOMA, CHROMOPHOBE; ADULT; AGED; CASE-CONTROL STUDIES; DNA MUTATIONAL ANALYSIS; DNA, MITOCHONDRIAL; HUMANS; MALE; MIDDLE AGED; OSTEOPOROSIS; OXIDATIVE STRESS; PITUITARY NEOPLASMS; POLYMERASE CHAIN REACTION; SEQUENCE DELETION; SPINAL FRACTURES;

EID: 0032865235     PISSN: 0937941X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001980050209     Document Type: Article

References (19)

1. Kreiger NS, Sessler NE, Bushinsky DA. Acidosis inhibits osteoblastic and stimulates osteoclastic activity in vitro. Am J Physiol 1992;262:F442-8.
2. Krapf R, Vetsch R, Vetsch W, Hutler HN. Chronic metabolic acidosis increases the serum concentration of 1,25-dihydroxyvitamin D in humans by stimulating its production rate: critical role of acid-induced phosphatemia. J Clin Invest 1992;90:2456-63.
3. Bushinsky DA. Net calcium efflux from live bone during chronic metabolic but not respiratory acidosis. Am J Physiol 1989;256:F836-42.
4. Sebastian A, Harris ST, Ottaway JH, Todd KM, Morris RC Jr. Improved mineral balance and mineral metabolism in postmenopausal women treated with potassium bicarbonate. N Engl J Med 1994;330:1776-81.
5. Wallace DC. Mitochondrial diseases: genotype versus phenotype. Trends Genet 1993;9:128-33.
6. Stacpoole PW. Lactic acidosis and other mitochondrial disorders [review]. Metabolism 1997;46:306-21.
7. Cortopassi GA, Arnheim N. Detection of specific mitochondrial DNA deletion in tissues of older humans. Nucleic Acids Res 1990;18:6927-33.
8. Cortopassi GA, Shibata D, Soong NW. A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc Natl Acad Sci USA 1992;89:7370-4.
9. Lee HC, Pang CY, Hsu HS, Wei YH. Differential accumlations of 4977 bp deletion in mitochondrial DNA of various tissues. Biochim Biophys Acta 1994;1226:37-43.
10. Baillie SP, Davison CE, Johnson FJ, Francis RM. Pathogenesis of vertebral crush fractures in men. Age Ageing 1992;21:139-41.
11. Sato W, Tanaka M, Ohno K, Yamamoto T, Takada G, Ozawa Y. Multiple populations of deleted mitochondrial DNA detected by a novel gene amplification method. Biochem Biophys Res Commun 1991;162:664-72.
12. Hattori K, Tanaka M, Sugiyama S, Obayashi T. Ito T, Satake T, et al. Age dependent increase in deleted mitochondrial DNA in the human heart: possible contributory factor to presbycardia. Am Heart J 1991;121:1735-42.
13. Rotig A, Cormier V, Blanche S, Bonnefont JP, Ledeist R, Romero N, et al. Pearson's marrow-pancreas syndrome: a multisystem mitochondrial disorder in infancy. J Clin Invest 1990;86:1601-8.
14. Teti A, Blair HC, Schlesinger P, Grano M, Zambonin-Zallone A, Kahn AJ, et al. Extracellular protons acidify osteoclasts, reduce cystosolic calcium, and promote expression of cell-matrix attachment. J Clin Invest 1989;84:773-80.
15. Arnett TR, Dempster DW. Effect of pH on bone resorption by rat osteoclasts in vitro. Endocrinology 1986;119:119-24.
16. Papiha SS, Rathod H, Briceno I, Pooley J, Datta HK. Age related mitochondrial deletions in bone. J Clin Pathol 1998:51:117-20.
17. Datta HK, Rathod H, Manning P, Turnbull Y, McNeil C. Parathyroid hormone induces superoxide burst in the osteoclast: evidence for the direct instantaneous action by the hormone. J Endocrinol 1996;149:269-75.
18. Bonjour JP, Thientz G, Buchs B, Slosman D, Rizzoli R. Criticial years and stages of puberty for spinal and femoral bone mass accumulation during adolescence. J Clin Endocrinol Metab 1991;73:555-63.
19. Wallace DC. Mitochondrial genetics: a paradigm for aging and degenerative disease. Science 1992:256:628-32.